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To observe the clinical efficacy of Qingre Jiedu Decoction（清热解毒汤）in the treatment of severe psoriasis vulgaris（blood-heat type）and its impacton serum inflammation and immune function in patients.
A prospective study was conducted on 100 patients with psoriasis vulgaris who received treatment at Shengli Oilfield Central Hospital in Dongying City.They were divided into a control group and an observation group in the order of admission，with 50 patients in each group.The control group received conventional Western medicine treatment，while the observation group received oral administration with Qingre Jiedu Decoction for 8 weeks.The total effective rate，traditional Chinese medicine syndrome scores，serum inflammation level，immune function and adverse reactions between two groups were compared.
The total effective rate of the observation group（96.00%）was significantly better than that（84.00%）of the control group，and the difference was statistically significant（P<0.05）.Before intervention，there was no significant difference in skin lesions and quality of life scores between the two groups（P>0.05）.After8 weeks of intervention，compared with those of the controlgroup，the psoriasis area and severity index（PASI）and dermatology life quality index（DLQI）of the observation group were significantly reduced（P<0.01）.The scores of symptoms such as rash color，burning sensation，itching and irritability in the observation group significantly decreased（P<0.01）.There was no significant difference in serum inflammation or T lymphocyte subsets levels between the two groups before intervention.After 8 weeks of intervention，the levels of serum tumor necrosis factor-α（TNF-α），transforming growth factor-β（TGF-β）and interleukin-6（IL-6）of the observation group were significantly down-regulated compared to those of the control group（P<0.01）.The levels of CD3+，CD4+and CD4+/CD8+in the observation group were significantly increased compared to those in the control group，while the levels of CD8+were significantly decreased，with statistical significance（P<0.01，P<0.05）.The incidence of adverse reactions in the observation group（16.00%）showed no significant difference compared to that（10.00%）in the control group（P>0.05）.
The combination of Qingre Jiedu Decoction（Psoriasis External Wash No.1 Formula）and Avia Capsules can improve the clinical efficacy in patients with severe psoriasis vulgaris，further improve the clinical symptoms，enhance the quality of life and significantly reduce PASI，and the mechanism of action is related to inhibiting the body's inflammatory response and regulating immune function.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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