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Research Progress of Traditional Chinese Medicine Targeting Nrf2 Signaling Pathway in Prevention and Treatment of Atherosclerosis
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Liqiang SUN1, 2, 3, Zhengtao CHEN1, 2, 3, Jianguang WU1, 2, 3, Junyu LAI1, 2, 3, Zhongyong LIU1, 2, 3
Chinese Archives of Traditional Chinese Medicine | 2025, 43(12) : 172 - 182
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Chinese Archives of Traditional Chinese Medicine | 2025, 43(12): 172-182
• Target on National Project •
Research Progress of Traditional Chinese Medicine Targeting Nrf2 Signaling Pathway in Prevention and Treatment of Atherosclerosis
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Liqiang SUN1, 2, 3, Zhengtao CHEN1, 2, 3, Jianguang WU1, 2, 3, Junyu LAI1, 2, 3, Zhongyong LIU1, 2, 3
Affiliations
  • 1.Jiangxi University of Chinese Medicine，Nanchang 330004，Jiangxi，China
  • 2.Affiliated Hospital of Jiangxi University of Chinese Medicine，Nanchang 330006，Jiangxi，China
  • 3.Jiangxi Province Key Laboratory of Cardiovascular Diseases of Traditional Chinese Medicine，Nanchang 330006，Jiangxi，China
Published: 2025-12-10 doi: 10.13193/j.issn.1673-7717.2025.12.031
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Atherosclerosis（AS）is a chronic and complex disease that occurs in the arterial wall and underlies a variety of cardiovascular pathologies.Nuclear factor erythroid 2-related factor 2（Nrf2）is an anti-oxidative stress high-sensitivity transcription factor that interacts with antioxidant response element（ARE）to activate downstream gene transcription and exerts various protective effects such as anti-inflammation，antioxidant and detoxification，thus protecting cellular components such as endothelial cells，macrophages，vascular smooth muscle cells，endothelial progenitor cells and so on in arterial vascular tissue，and plays an important role in the development of AS.Traditional Chinese medicine（TCM）has significant advantages in the treatment of AS due to its multi-targets and multi-pathways，stable efficacy，individualisation and safety.This article summarized the mechanism of Nrf2 regulation by TCM monomers，TCM extracts，TCM combinations and proprietary Chinese medicines in the prevention and treatment of AS，with a view to providing a theoretical basis for clinical research and drug development in the prevention and treatment of AS.

nuclear factor erythroid 2-related factor 2  /  atherosclerosis  /  traditional Chinesemedicine  /  pathogenesis
孙礼强, 陈正涛, 伍建光, 赖俊宇, 刘中勇. 中医药靶向Nrf2信号通路防治动脉粥样硬化研究进展. 中华中医药学刊, 2025 , 43 (12) : 172 -182 . DOI: 10.13193/j.issn.1673-7717.2025.12.031
Liqiang SUN, Zhengtao CHEN, Jianguang WU, Junyu LAI, Zhongyong LIU. Research Progress of Traditional Chinese Medicine Targeting Nrf2 Signaling Pathway in Prevention and Treatment of Atherosclerosis[J]. Chinese Archives of Traditional Chinese Medicine, 2025 , 43 (12) : 172 -182 . DOI: 10.13193/j.issn.1673-7717.2025.12.031
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Year 2025 volume 43 Issue 12
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545
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doi: 10.13193/j.issn.1673-7717.2025.12.031
  • Online Date：2026-04-29
  • Published：2025-12-10
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    1.Jiangxi University of Chinese Medicine，Nanchang 330004，Jiangxi，China
    2.Affiliated Hospital of Jiangxi University of Chinese Medicine，Nanchang 330006，Jiangxi，China
    3.Jiangxi Province Key Laboratory of Cardiovascular Diseases of Traditional Chinese Medicine，Nanchang 330006，Jiangxi，China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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