Multiplemyeloma(MM)is one of the most common malignant tumors of the hematologic system,with multiple myeloma bone disease(MBD)as a hematological complication.MBD is prominently characterized by pathological fractures,osteoporosis and osteolytic lesions,all of which severely impact patients'quality of life and survival rates.The primary mechanisms of MBD involve bone destruction and impaired osteogenesis,especially the abnormal activation of the receptor activator of nuclear factor kappa B(RANK)/ligand of RANK(RANK-L)/osteoprotegerin(OPG)system,along with an imbalance in the regulation of osteoclast and osteoblast function by pro-inflammatory cytokines in the bone marrow microenvironment.In recent years,substantial progress has been achieved in MBD treatment through integrated traditional Chinese and Western therapeutic strategies.This combined approach harnesses multiple therapeutic advantages to alleviate bone pain,enhance bone strength and reduce the risk of complications.To standardize this integrated diagnosis and treatment protocol,an expert team has developed a consensus based on evidence-based medicine and regional resources in traditional Chinese and Western medicine within the Lingnan area.This consensus aims to provide guidance for clinical practice and improve patients'quality of life and prognosis.
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |