Latest ArticlesTo explore the efficacy of Fuzheng Qufeng Decoction in patients with chronic urticaria, its effects on the Weekly Urticaria Activity Score (UAS7), Dermatology Life Quality Index (DLQI), and serum C-reactive protein (CRP) and immunoglobulin levels. Additionally, it evaluated the decoction's regulatory effects on serum inflammatory factors, chemokines, and immune function.
This prospective study enrolled 211 patients with chronic urticaria treated at our hospital from March 2020 to March 2024. Patients were randomly assigned into a control group (n=106), receiving levocetirizine hydrochloride tablets, and an observation group (n=105), receiving Fuzheng Qufeng Decoction in combination with levocetirizine hydrochloride. Both groups were treated for 4 weeks. UAS7 and DLQI scores were evaluated before and after treatment in both groups. Traditional Chinese Medicine (TCM) symptom scores, serum levels of inflammatory cytokines, chemokines, and immune function-related indicators were measured and compared between the two groups. The efficacy and incidence of adverse reactions were statistically analyzed.
After treatment, both the UAS7 and DLQI scores decreased in the observation group and the control group, with median UAS7 and DLQI scores in the observation group being 7.00 and 2.00, respectively, both lower than the control group's 7.50 and 3.00 (P < 0.05). The primary and secondary symptom scores of Traditional Chinese Medicine (TCM) syndromes also decreased in both groups, with the observation group showing significantly lower scores than the control group (P <0.05). Post-treatment, serum levels of IL-17, IL-23, IL-31, IL-33, IFN-γ, TGF-β, CRP, SAA, D-dimer, MCP-1, RANTES, Eotaxin, C5a, and IgE were all lower in the observation group compared to the control group (P <0.05), while serum C3 and C4 levels were higher in the observation group (P <0.05). The total treatment efficacy rate in the observation group was higher than that in the control group. The total incidence of adverse reactions in the observation group was lower than that in the control group (P < 0.05).
Fuzheng Qufeng Decoction significantly improved clinical symptoms, reduced UAS7 and DLQI scores, lowered serum levels of inflammatory cytokines and chemokines, enhanced immune function, and demonstrated high safety with fewer adverse reactions. It holds substantial clinical value for treating chronic urticaria.
To evaluate the efficacy of celecoxib combined with Danggui Niantong Decoction in the treatment of cervical spondylotic radiculopathy Wind-Damp-Heat Obstruction syndrome).
A total of 98 patients with cervical radiculopathy (Wind-Damp-Heat Obstruction syndrome) admitted to the orthopedics and inpatient department of Huanggang Central Hospital from January 2023 to December 2023 were selected as the study objects, and were divided into 2 groups according to random number table method, with 49 cases each. The control group was treated with celecxib on the basis of cervical traction therapy, and the experimental group was treated with Danggui Niantong Decoction on the basis of control group for 4 weeks. The clinical efficacy, TCM symptom score, VAS scale score, NDI questionnaire, CASCS scale score, serum inflammatory indicators IL-1β, IL-6β, TNF-αlevel and incidence of adverse reactions were compared between the two groups.
The total effective rate of experimental group after treatment was significantly higher than that of control group (P < 0.05). After treatment, TCM symptom score of two groups was significantly decreased, and the test group was lower than the control group(P < 0.05). VAS and NDI scores after treatment were lower than before treatment, CASCS scores were higher than before treatment, and the change range of experimental group was higher than that of control group (P <0.05). The serum levels of IL-1β, IL-6β and TNF-αin 2 groups after treatment were lower than before treatment, and the experimental group was lower than the control group(P < 0.05).
Danggui Niantong Decoction combined with celecxib has a good effect in the treatment of cervical spondylopathy patients with rheumatic heat arthralgia nerve root type, which can significantly improve cervical spine function and clinical symptoms, reduce the level of pain and inflammatory factors, and is safe, worthy of clinical promotion.
To observe the effects of self-formulated modified Tiaoying Decoction with modifications combined with herb-partitioned moxibustion on immune regulation, platelet parameters and the number and function of endothelial progenitor cells in peripheral blood of patients with myeloid suppression anemia after chemotherapy for advanced gastric cancer.
We selected 104 patients with myelosuppressive anemia after chemotherapy for advanced gastric cancer who were treated in Hengshui Hospital of Traditional Chinese Medicine from April 2022 to April 2024. They were divided into a control group of 52 cases (3 cases dropped out, and finally 49 cases were included) and a treatment group of 52 cases (4 cases dropped out, and finally 48 cases were included) by the random number table method. Both groups were given routine Western medicine treatment simultaneously. The treatment group was given herb-partitioned moxibustion combined with self-formulated modified Tiaoying Decoction with modifications on the basis of routine Western medicine treatment. After the treatment course, the clinical efficacy of the two groups was compared. Before and after treatment, the scores of various traditional Chinese medicine syndromes were observed. The quality of life was evaluated by the Functional Assessment of Cancer Therapy-General (FACT-G). The levels of neutrophils, hemoglobin, white blood cell count and platelet count of patients were detected. The number and migration ability of circulating endothelial progenitor cells in peripheral blood were detected. The levels of reactive oxygen species (ROS), granulocyte-macrophage colony-stimulating factor (GM-CSF), Notch2, Numb1, CD4+ cells, CD8+cells and CD16+ CD56+ cells in patients were detected. The 1-year recurrence rate and 1-year survival rate of the two groups of patients were compared.
The treatment group's total effective rate was 95.83%. The control group's total effective rate was 79.59%. The treatment group's total effective rate was higher than the control group (P < 0.05). The treatment group's scores of TCM syndrome was lower than control group (P < 0.05). The treatment group's FACT-G scores was higher than the control group (P <0.05). The treatment group's neutrophil, hemoglobin, white blood cell count and platelet count in treatment group levels were higher than control group (P < 0.05). The treatment group's number and migration ability of peripheral blood circulating endothelial progenitor cells were lower than control group (P <0.05). The treatment group's CD4+ cells and CD16+ CD56+ cells levels were higher than control group (P < 0.05). The treatment group's expression of CD8+ cells was lower than control group (P < 0.05). The treatment group's ROS, GM-CSF and Notch2 expression levels were lower than control group (P < 0.05). The treatment group's expression level of Numb1 was higher than that in the control group (P < 0.05). The 1-year recurrence rate of the treatment group was 31.25%, which was lower than 53.06% of the control group (P < 0.05), and the 1-year survival rate of the treatment group was 97.92%, which was higher than 81.63% of the control group (P < 0.05).
Self-formulated modified Tiaoying Decoction with modifications combined with herb-partitioned moxibustion can reduce the oxidative stress response, regulate the immune function and platelet parameters of patients, improve the number and function of peripheral blood endothelial progenitor cells, alleviate the disease, and improve the clinical efficacy and quality of life in the treatment of patients with advanced gastric cancer after chemotherapy.
Rich in flavonoids, fatty acids, polysaccharides, and other physiologically active components, sea buckthorn is a type of plant that has medicinal and culinary similarities. It also has significant antioxidant, hypoglycemic, and hypolipidemic properties, as well as the ability to inhibit tumor growth and lessen cardiovascular disease. The identification, processing, and functional characteristics of sea buckthorn have been the focus of both domestic and international research. Nevertheless, there is an absence of systematic searching and a scattering of research on the pharmacological benefits of sea buckthorn in the prevention and treatment of cardiovascular illnesses. Based on electronic databases including PubMed, CNKI, and Wanfang Data, we provide an overview of the pharmacological effects of sea buckthorn in cardiovascular disorders in this work.
Epilepsy is a neurological disorder characterized by complex and diverse pathogenesis, involving abnormal activation of multiple signaling pathways. In recent years, with the in-depth study of the pathogenesis of epilepsy, traditional Chinese medicine (TCM) has shown unique advantages as a traditional treatment method in the treatment of epilepsy. Especially, TCM has exerted significant anti-epileptic effects by regulating the Toll-like receptor 4 (TLR4) nuclear factor NF-κB signaling pathway. This article aims to review the latest research progress of TCM in regulating the TLR4/NF-κB pathway, focusing on analyzing the mechanisms of active components and compound prescriptions of traditional Chinese medicine via the TLR4/NF-κB pathway, in order to provide reference and inspiration for future research.
The incidence and mortality rates of lung cancer remain the highest among all cancers. Although advances have been made in Western medical treatments, limitations still exist due to adverse reactions and drug resistance. The Traditional Chinese Medicine (TCM) theory of "the lung and large intestine being interiorly-exteriorly related" is associated with the modern medical concept of the "lung-gut axis. "It is well-established that both gut microbiota and short-chain fatty acids (SCFAs) are closely linked to the occurrence and progression of lung cancer. This study aims to explore the feasibility and effectiveness of intervening in lung cancer based on the "lung and large intestine being interiorly-exteriorly related" theory from the perspective of SCFAs. The importance of SCFAs in lung cancer treatment and prognosis will be analyzed. A new strategy for intervening in lung cancer by regulating intestinal SCFA levels will be proposed, providing new ideas and methods for comprehensive treatment and prognostic improvement of lung cancer.
The incidence of Premature Ovarian Insufficiency (POI) is on the rise year by year. Traditional Chinese medicine holds that the imbalance of the Chong and Ren meridians is the core pathogenesis of POI, and the function of the Chong and Ren meridians is similar to that of the ovary in Western medicine. This article aims to explore the integration of the theory of "regulating the Chong and Ren meridians" in traditional Chinese medicine and the theory of "improving the microenvironment of the ovary" in Western medicine, providing an innovative perspective for the diagnosis and treatment of early-onset ovarian insufficiency in traditional Chinese medicine and revealing the deep consensus of both traditional Chinese and Western medicine in the regulation of female reproduction.
To observe the effect of Bear bile and UDCA on circulating blood Ly6Chigh monocyte chemotaxis receptor CCR2 and its ligand CCL2 (MCP-1) in model mice with Immune Thrombocytopenia (ITP), and explore the possible mechanism of regulating Ly6Chigh monocyte migration and reference studies on bear bile and its replacements in ITP management.
Following established methods, an ITP model was induced via immunization in 50 BALB/c mice, randomLy allocated into five groups: normal control, model control, prednisone treatment, bear bile treatment, and UDCA treatment, from the 6th day of making model, mice in the each group was administered 0.4 mL/d volume of corresponding drug by irrigation treatment. From the 6 h, 7th day, 15th day, automatic blood cytometer was used to dynamic detect platelet count. after treatment 10 day, Flow cytometry was used to detect the changes of the Ly6Chigh monocyte in circulating blood, Enzyme-linked immunosorbent Assay was used to detect the levels of serum MCP-1 (monocyte chemotactic protein-1).
After the 6 hour of making model, the counts of platelet decreased obviously in all group, reaching the lowest point on the 7th day, and remained at a relatively low level until the 15th day. There was a statistically significant difference compared to the normal group (P < 0.05). After treatment, the platelet counts of bear bile, prednisone and UDCA group increased obviously (P < 0.01). Flow cytometry results showed that compared with the model group, the positive rate of circulating Ly6Chigh monocytes and its surface chemokine receptor CCR2 in bear bile, UDCA and prednesone groups decreased (P < 0.01, P < 0.001), while CX3CR1 expression increased (P < 0.001). Enzyme-linked immunosorbent Assay results showed that compared with the model group, the levels of MCP-1 in bear bile, UDCA and prednesone groups decreased(P < 0.001).
The Bear bile and UDCA can downregulate the expression of CCR2 by reducing the level of MCP-1 in circulating blood, thus governs CCL2-CCR2 mediated Ly6Chigh monocyte emigration, reduce the Ly6Chigh monocytes in the circulating blood, this represents a crucial mechanism driving Ly6Chigh monocyte accumulation during ITP progression and worsening.
To investigate the mechanism by which Yiqi Huoxue Lishui Decoction ameliorates hepatic fibrosis (HF) in rats by inhibiting hepatocyte ferroptosis via activation of the nuclear factor-E2-related factor 2 (Nrf2)/glutathione peroxidase 4 (GPX4) signaling pathway.
Forty Sprague-Dawley (SD) rats were randomly divided into five groups (n =8 per group) : the control group (Control), model group (Model), traditional Chinese medicine group (TCM), traditional Chinese medicine + ferroptosis inhibitor group (TCM + Fer-1), and traditional Chinese medicine + ferroptosis inhibitor + autophagy inhibitor group (TCM + Fer-1 + 3-MA). The model was established by intraperitoneal injection of a 50% carbon tetrachloride (CCl4) solution (1.5 mL/kg), administered twice weekly for 4 weeks. Treatment groups received their respective interventions: the Yiqi Huoxue Lishui Decoction was administered via oral gavage (2 mL/100 g), while the ferroptosis inhibitor Ferrostatin-1(Fer-1) (1 mg/kg) and the autophagy inhibitor 3-Methyladenine (3-MA) (15 mg/kg) were administered via intraperitoneal injection. All administrations were performed once daily for 4 weeks, while the other groups were given an equivalent volume of normal saline. Hepatic histopathological changes were evaluated using hematoxylin-eosin (HE) and Masson staining. Serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), tumor necrosis factor-α (TNF-α), superoxide dismutase (SOD), malondialdehyde (MDA), and Fe2+ content in serum and liver tissue were measured. Western blot (WB) was employed to assess protein expression of GPX4, Nrf2, solute carrier family 7 member 11 (SLC7A11), transferring receptor 1 (TFR1), Beclin-1, and the LC3 II/I ratio. Quantitative real-time polymerase chain reaction (qPCR) was utilized to determine mRNA expression levels of Nrf2 and GPX4.
Compared with the Control group, the Model group exhibited severe hepatic steatosis, significant fibrosis, elevated collagen deposition, increased serum AST, ALT, MDA, TNF-α, and Fe2+ levels, and reduced SOD activity (P < 0.05). Protein expression of GPX4, Nrf2, and SLC7A11 was upregulated, while TFR1 and Beclin-1 expression increased, and mRNA levels of GPX4 and Nrf2 were markedly suppressed (P < 0. 05). Intervention with Yiqi Huoxue Lishui Decoction and/or inhibitors significantly attenuated histopathological damage, reduced AST, ALT, MDA, TNF-α, Fe2+ levels, and downregulated TFR1 and Beclin-1 expression (P < 0.05). Concurrently, SOD activity, GPX4 and Nrf2 protein/mRNA expression, and SLC7A11 protein levels were elevated (P <0. 05). No significant difference was observed in the LC3 Ⅱ/Ⅰ ratio across groups(P > 0.05).
Yiqi Huoxue Lishui Decoction may ameliorate hepatic fibrosis by inhibiting ferroptosis through activation of the Nrf2/GPX4 signaling pathway.
To analyze the differences in chemical components between two types of Lycii cortex derived from Lycium chinense Mill. and Lycium barbarum L.
HPLC was used to establish the fingerprint profiles of the two kinds of Lycii cortex samples, and the common pattern diagrams were compared for similarity analysis. An HPLC method was developed for the determination of four components: (E)-N-caffeoylputrescine, scopoline, kukoamine B, kukoamine A. Combined with principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA), the differences in chemical components of Lycii cortex from different origins were compared.
HPLC fingerprints of Lycii cortex from different origins were established. Lycii cortex originated from Lycium chinense Mill. had 14 common peaks, while Lycii cortex originated from Lycium barbarum L. had 11 common peaks. Five common peaks were identified: (E)-N-caffeoylputrescine (Peak 1), scopolin (Peak 2), kukoamine B (Peak 3), kukoamine A (Peak 5), and scopoletin (Peak 6). The quantitative analysis showed good linearity for the four components within the concentration ranges of 1.37 ~ 87.80 μg·mL-1(r=0.999 9), 1.97 ~ 125.83 μg·mL-1(r=0.999 7), 6.31 ~ 403.76 μg·mL-1(r = 0.999 9), and 10.67 ~ 341.57 μg·mL-1 (r = 0.999 8), with average recoveries of 100.52% ~ 103.84% and RSD of 2.33% ~ 3.42%. The content determination results showed that the average percentages of the four components in Lycii cortex originated from Lycium barbarum L. were higher than in Lycium chinense Mill. Chemical pattern recognition analysis classified the two types of Lycii cortex into two categories, and (E)-N-caffeoylputrescine played a prominent role in model construction.
The established method is accurate and reliable, which can be utilized to distinguish the two varieties of Lycii Cortex and provide a reference for the quality control of them.
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