To observe the effects of self-formulated modified Tiaoying Decoction with modifications combined with herb-partitioned moxibustion on immune regulation, platelet parameters and the number and function of endothelial progenitor cells in peripheral blood of patients with myeloid suppression anemia after chemotherapy for advanced gastric cancer.

We selected 104 patients with myelosuppressive anemia after chemotherapy for advanced gastric cancer who were treated in Hengshui Hospital of Traditional Chinese Medicine from April 2022 to April 2024. They were divided into a control group of 52 cases (3 cases dropped out, and finally 49 cases were included) and a treatment group of 52 cases (4 cases dropped out, and finally 48 cases were included) by the random number table method. Both groups were given routine Western medicine treatment simultaneously. The treatment group was given herb-partitioned moxibustion combined with self-formulated modified Tiaoying Decoction with modifications on the basis of routine Western medicine treatment. After the treatment course, the clinical efficacy of the two groups was compared. Before and after treatment, the scores of various traditional Chinese medicine syndromes were observed. The quality of life was evaluated by the Functional Assessment of Cancer Therapy-General (FACT-G). The levels of neutrophils, hemoglobin, white blood cell count and platelet count of patients were detected. The number and migration ability of circulating endothelial progenitor cells in peripheral blood were detected. The levels of reactive oxygen species (ROS), granulocyte-macrophage colony-stimulating factor (GM-CSF), Notch2, Numb1, CD4⁺ cells, CD8⁺cells and CD16⁺ CD56⁺ cells in patients were detected. The 1-year recurrence rate and 1-year survival rate of the two groups of patients were compared.

The treatment group's total effective rate was 95.83%. The control group's total effective rate was 79.59%. The treatment group's total effective rate was higher than the control group (P < 0.05). The treatment group's scores of TCM syndrome was lower than control group (P < 0.05). The treatment group's FACT-G scores was higher than the control group (P <0.05). The treatment group's neutrophil, hemoglobin, white blood cell count and platelet count in treatment group levels were higher than control group (P < 0.05). The treatment group's number and migration ability of peripheral blood circulating endothelial progenitor cells were lower than control group (P <0.05). The treatment group's CD4⁺ cells and CD16⁺ CD56⁺ cells levels were higher than control group (P < 0.05). The treatment group's expression of CD8⁺ cells was lower than control group (P < 0.05). The treatment group's ROS, GM-CSF and Notch2 expression levels were lower than control group (P < 0.05). The treatment group's expression level of Numb1 was higher than that in the control group (P < 0.05). The 1-year recurrence rate of the treatment group was 31.25%, which was lower than 53.06% of the control group (P < 0.05), and the 1-year survival rate of the treatment group was 97.92%, which was higher than 81.63% of the control group (P < 0.05).

Self-formulated modified Tiaoying Decoction with modifications combined with herb-partitioned moxibustion can reduce the oxidative stress response, regulate the immune function and platelet parameters of patients, improve the number and function of peripheral blood endothelial progenitor cells, alleviate the disease, and improve the clinical efficacy and quality of life in the treatment of patients with advanced gastric cancer after chemotherapy.