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Exploration on the Regulation of Lung Cancer through Short-Chain Fatty Acids Based on the Theory of "Lung and Large Intestine Being Internally-Exteriorly Related"
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Lingli JIANG, Qiyuan MAO, Ying YANG, Genming ZHANG, Daorui LI*, Hongsheng LIN
Acta Chinese Medicine and Pharmacology | 2026, 54(6) : 1 - 5
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Acta Chinese Medicine and Pharmacology | 2026, 54(6): 1-5
Exploration on the Regulation of Lung Cancer through Short-Chain Fatty Acids Based on the Theory of "Lung and Large Intestine Being Internally-Exteriorly Related"
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Lingli JIANG, Qiyuan MAO, Ying YANG, Genming ZHANG, Daorui LI*, Hongsheng LIN
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  • Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
Published: 2026-06-20 doi: 10.19664/j.cnki.1002-2392.260110
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The incidence and mortality rates of lung cancer remain the highest among all cancers. Although advances have been made in Western medical treatments, limitations still exist due to adverse reactions and drug resistance. The Traditional Chinese Medicine (TCM) theory of "the lung and large intestine being interiorly-exteriorly related" is associated with the modern medical concept of the "lung-gut axis. "It is well-established that both gut microbiota and short-chain fatty acids (SCFAs) are closely linked to the occurrence and progression of lung cancer. This study aims to explore the feasibility and effectiveness of intervening in lung cancer based on the "lung and large intestine being interiorly-exteriorly related" theory from the perspective of SCFAs. The importance of SCFAs in lung cancer treatment and prognosis will be analyzed. A new strategy for intervening in lung cancer by regulating intestinal SCFA levels will be proposed, providing new ideas and methods for comprehensive treatment and prognostic improvement of lung cancer.

Lung and large intestine being interiorly-exteriorly related  /  Short-chain fatty acids  /  Lung cancer
Lingli JIANG, Qiyuan MAO, Ying YANG, Genming ZHANG, Daorui LI, Hongsheng LIN. Exploration on the Regulation of Lung Cancer through Short-Chain Fatty Acids Based on the Theory of "Lung and Large Intestine Being Internally-Exteriorly Related"[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (6) : 1 -5 . DOI: 10.19664/j.cnki.1002-2392.260110
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Year 2026 volume 54 Issue 6
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doi: 10.19664/j.cnki.1002-2392.260110
  • Receive Date：2025-04-22
  • Online Date：2026-09-17
  • Published：2026-06-20
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  • Received：2025-04-22
  • Revised：2025-12-11
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    Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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