To explore the effect of Jianpi Ziyin Decoction（健脾滋阴汤）combined with atorvastatin on the improvement of traditional Chinese medicine syndrome characteristics，hemorrheology and electrocardiogram in patients with coronary heart disease microcirculation disorders.

A hundred patients with coronary heart disease microcirculatory disorder of Qi deficiency and blood stasis syndrome were enrolled in the hospital，and the patients were randomly divided into an observation group and a control group according to the random number table method，50 cases in each.The control group was given atorvastatin calcium tablets，and the observation group was given Jianpi Ziyin Decoction on the basis of the treatment plan of the control group.After treatment，the clinical efficacy，TCM clinical symptom scores，microcirculatory function，hemorrheology，blood lipid levels and electrocardiogram efficacy of the two groups were observed before and after treatment.

After treatment，the total effective rate of the observation group was 92.00%，which was significantly higher than that（74.00%）in the control group（P<0.05）.After treatment，the TCM clinical symptom scores of the two groups were significantly improved compared with those before treatment（P<0.05）.The symptom scores of the observation group in terms of chest tightness，chest pain，fatigue，palpitations，shortness of breath，insomnia and night sweats were significantly better than those in the control group（P<0.05）.The coronary flow reserve（CFR）of the two groups after treatment was higher than that before treatment.There was a significant improvement（P<0.05），and the CFR improvement of the observation group was significantly better than that the control group（P<0.05）.After treatment，the index of microcirculatory（IMR）of both groups decreased significantly compared with those be-fore treatment（P<0.05）and the index of the observation group was significantly better than that of the control group（P<0.05）.After treatment，the blood rheology indexes of both groups were significantly lower than those before treatment（P<0.05）.The whole blood viscosity high shear，whole blood viscosity low shear，platelet aggregation rate and red blood cell aggregation index in the observation group were significantly better than those in the control group（P<0.05）.The blood lipid levels in both groups after treatment were significantly improved compared with those before treatment（P<0.05）.The observation group had lower levels of total cholesterol（TC），triglycerides（TG），low-density lipoprotein cholesterol（LDL-C）and highdensity lipoprotein cholesterol（HDL-C）than the control group（P<0.05）.After treatment，the total ST segment effective rate of the observation group was 92.00%，which was significantly higher than that（70.00%）in the control group（P<0.05）.After treatment，the total effective rate of T-band in the observation group was 90.00%，which was significantly higher than that in the control group（78.00%）（P<0.05）.

Jianpi Ziyin Decoction combined with atorvastatin can effectively improve the clinical treatment effect，the clinical symptoms and microcirculation function，reduce the blood rheology and blood lipid levels and improve the electrocardiogram of patients with coronary heart disease.

Based on the theoretical foundation of“ascending the clear and descending the turbid”，to investigate the pathogenesis of slow transit constipation（STC）by studying aquaporin-3（AQP3），aquaporin-4（AQP4）and aquaporin-9（AQP9）in the colon of rats with STC.

Sixty clean grade SD rats were provided by the Animal Experimental Center of North Sichuan Medical College.They were randomly divided into normal group，model group，itopride group，high，medium and low dose groups of Baizhu（Atractylodis Macrocephalae Rhizoma）.Firstly，a rat model of STCwas established，and its therapeutic effect was observed by administering the corresponding medication.The contents，distributions and expressions of AQP3，AQP4 and AQP9 in the colon of rats in each group were detected by immunohistochemistry，q-PCR and Western blot methods，and the average optical density（MOD）value of the region was measured.

After modeling，the content of AQP9 decreased，and the distal colon tissue decreased more significantly，while the content of AQP3 increased，and the proximal colon tissue became more significant.The content of AQP4 in colon tissue also increased significantly.After drug intervention treatment，the AQP4 contents in the high dose group of Baizhu（Atractylodis Macrocephalae Rhizoma）and the itopride group significantly decreased，the AQP3 content in the proximal colon significantly decreased，and the AQP9 content in the distal colon significantly increased，with statistically significant differences.There was a decreasing trend in proximal AQP3 and an increasing trend in AQP9 content in the distal colon of the medium and low dose groups of Baizhu（Atractylodis Macrocephalae Rhizoma），but the difference was not statistically significant.

An increase in AQP3 content（proximal colon），a decrease in AQP4 content（whole colon）and a decrease in AQP9 content（distal colon）may be one of the pathogenesis of STC.Baizhu（Atractylodis Macrocephalae Rhizoma）down-regulates the expressions of AQP3 and AQP4，and up-regulates the expression of AQP9，which may be one of the mechanisms by which it exerts its“ascending the clear and descending the turbid”effect to treat STC.

To study curative effect of Banxia Xiexin Decoction（半夏泻心汤）on gastric epithelial dysplasia and its influence on immune function and gastric mucosa inflammatory reaction.

Eighty cases with gastric epithelial dysplasia（dampness-heat syndrome of spleen and stomach）were divided into the control group and the study group with 40 cases in each by digital table method.The control group was treated with conventional western medicine，and the observation group was treated with Banxia Xiexin Decoction.The course was12 weeks.The changes of TCM syndrome scores，immune function and gastric mucosal inflammation were observed before and after treatment.

There was no significant difference in fullness，stomachache，fatigue，loose stool，belching，lethargy and lack of thirst between the two groups before treatment（P>0.05）.After treatment，the score decreased（P<0.001），and the degree of decline in the observation group was greater than that in the control group（P<0.001）.There was no significant difference in the levels of CD⁺₃，CD⁺₄ or CD⁺₈ between the two groups before treatment（P>0.05），and the levels of CD⁺₃ and CD⁺₄ were higher than those before treatment（P<0.001），and the increases in the observation group were greater than those in the control group（P<0.001）.There was no significant difference in serum levels of interleukin-6（IL-6），interleukin-2（IL-2），interleukin-17（IL-17）or tumor necrosis factor-α（TNF-α）between the two groups before treatment（P>0.05），and the levels of IL-6，IL-17 and TNF-αwere decreased compared with those before treatment（P<0.001）.The decrease of IL-2 in the observation group was greater than that in the control group（P<0.001），and the increase of IL-2 in the observation group was greater than that in the control group（P<0.001）.The therapeutic effect of the observation group was better than that of the control group（P<0.05）.

Banxia Xiexin Decoction in the treat-ment of gastric mucosal dysplasia（dampness-heat syndrome of spleen and stomach）can help to alleviate disease-related symptoms，improve the immune function，inhibit the inflammatory response and improve the therapeutic effect.

To analyze the effect of Feipingxiao Decoction（肺平哮汤）combined with respiratory rehabilitation on pulmonary function and immune function in children with bronchial asthma.

A total of 150 children with bronchial asthma admitted to the hospital were selected and randomly divided into control group and observation group，75 cases in each group.The control group was treated with inhaled glucocorticoids，and the observation group was given Feipingxiao Decoction combined with respiratory rehabilitation on this basis，and both groups were treated for 7 days.After treatment，the clinical treatment effect，symptom disappearance time，lung function，inflammatory factors and immune function were compared between the two groups.

The total effective rate of the treatment observation group was 90.67%，which was significantly higher than that of the control group（73.33%）（P<0.05）.After treatment，the disappearance time of wheezing，rales，asthma and cough symptoms in the observation group was significantly shorter than that of the control group（P<0.05）.The levels of forced expiratory volume in 1 second（FEV1），forced vital capacity（FVC）and FEV1/FVC in both groups were significantly improved after treatment（P<0.05）.The improvement of each index in the observation group was significantly better than that in the control group（P<0.05）.The levels of C-reactive protein（CRP）and transforming growth factorβ1（TGF-β1），tumor necrosis factor-α（TNF-α）and interleukin-4（IL-4）were significantly lower than those before treatment（P<0.05）.The improvement of the indicators in the observation group was significantly better than that in the control group（P<0.05）.After treatment，the levels of immunoglobulin G（IgG），immunoglobulin A（IgA）and immunoglobulin M（IgM）were significantly higher than those before treatment（P<0.05），and the improvement of various indicators in the observation group was significantly better than that in the control group（P<0.05）.

Feipingxiao Decoction combined with respiratory rehabilitation can significantly improve the clinical treatment effect of children with bronchial asthma，promote the improvement of clinical symptoms，reduce the levels of inflammatory factors，and improve the pulmonary function and immune function of children.

To analyze the clinical effect of Danggui Shaoyao Powder（当归芍药散）assisted by massage along meridian on pelvic floor rehabilitation of chronic pelvic pain with Qi deficiency and blood stasis.

One hundred and twelve patients with chronic pelvic pain of Qi deficiency and blood stasis were enrolled in the hospital from January 2021 to June 2022.They were randomly divided into the study group（56 cases）and the control group（56 cases）.Both groups received pelvic floor rehabilitation intervention and massage along the meridian，and the study group was given Danggui Shaoyao Powder orally.The treatment of both groups lasted for 12 weeks.The clinical symptom score，pain visual analogue scale（VAS），pelvic floor resting potential and quality of life of the two groups were compared before and after treatment，and the clinical efficacy of the two groups was evaluated.

After 12 weeks of treatment，the symptom scores of lower abdominal pain，lumbosacral pain，abnormal leukorrhagia，aggravation after fatigue and mental fatigue in the two groups decreased，and the rest potential of pelvic floor decreased before and after treatment，and the scores of various dimensions of quality of life increased.After 12 weeks'treatment，the scores of clinical symptoms and resting potential before and after pelvic floor in the study group were lower than those in the control group，and the scores of quality of life in all dimensions were higher than those in the control group，with statistical significance（P<0.05）.After 1，4，8 and 12 weeks of treatment，the VASscores of the two groups decreased compared with those before treatment，and the VASscores of the study group were lower than those of the control group at all time points after treatment with statistical significance（P<0.05）.After 12 weeks of treatment，the total clinical effective rate in the study group was 92.86%，which was higher than that in the control group（76.79%），and the difference was statistically significant（P<0.05）.

On the basis of pelvic floor rehabilitation and massage along meridians，Danggui Shaoyao Powder can further improve patients'clinical symptoms，relieve pain and regulate pelvic floor resting potential，which is of positive significance for improving patients'quality of life and clinical efficacy.

To analyze the clinical value of Modified Xiaoji Yinzi（小蓟饮子加减）combined with Compound Mufurong Nasal Ointment（复方木芙蓉涂鼻软膏）in treating epistaxis in Little's area.

Seventy children with epistaxis in Little's area admitted to the hospital from January 2022 to May 2022 were randomly divided into a combined group and a control group，with 35 cases in each group.The two groups were treated with nasal irrigation with normal saline，erythromycin eye ointment and Compound Mufurong Nasal Ointment，while the combined group was treated with Modified Xiaoji Yinzi.The therapeutic effects，symptoms and changes of blood routine test results of the two groups were compared，and the clinical value of the two treatment schemes was analyzed.

After 7 days of treatment，the symptoms of epistaxis，nasal cavity ulcer and nasal cavity erosion in the two groups were significantly improved compared with those before treatment.After 7 days of treatment，the incidence of epistaxis，nasal cavity ulcer and nasal cavity erosion in the combined group was lower than that in the control group，with statistical significance（P<0.05）.After 7 days of combined treatment，the total clinical effective rate of group A was 100.00%，which was higher than that of the control group（82.86%）with statistical significance（P<0.05）.After 7 days of treatment，the levels of white blood cells（WBC）and C-reaction protein（CRP）in both groups decreased compared with those before treatment.After 7 days of treatment，the levels of WBC and CRP in the combined group were lower than those in the control group with statistical significance（P<0.05）.There was no recurrence in the two-month follow-up of the effective group，but there were 5 cases in the control group，with a recurrence rate of 17.24%（5/29），and the difference between the two groups was statistically significant（P=0.037）.

On the basis of Compound Mufurong Nasal Ointment，the clinical effect of treating epistaxis in Little's area by combined application of Modified Xiaoji Yinzi is more significant，and there are obvious advantages in improving children's symptoms，alleviating inflammatory reaction，preventing anemia and reducing the risk of recurrence.

Identification，content determination and characteristic spectrum analysis of different Chenxiang（Aquilariae Lignum Resinatum）components obtained by artificial induction method were carried out using thin layer chromatography（TLC）and high performance liquid chromatography（HPLC）to evaluate the quality and quantity of Chenxiang（Aquilariae Lignum Resinatum）.

This article used chloroform-ether（10：1）as the developing agent to perform TLC identification on this batch of Chenxiang（Aquilariae Lignum Resinatum）samples.Content determination and characteristic spectrum were performed using HPLC under the following chromatographic conditions.Waters Symmetry Shield ^TM RP18 column（4.6 mm×250 mm，5μm）was used.The acetonitrile 0.1% formic acid water was as the mobile phase.The column temperature was 30℃.The flow rate was 0.7 mL·min^-1.The detection wavelength was 252 nm.The injection volume was 10μL.Finally，similarity evaluation，Principal Component Analysis（PCA）and Orthogonal Partial Least Squares Discriminant Analysis（OPLS-DA）were used to screen for chromatographic peaks that caused significant differences in different parts（trunk and branch）.

The results of TLC showed that the spots of the Chenxiang（Aquilariae Lignum Resinatum）samples were basically the same as those of the control herb.Examining the test product under the UV lamp at 254 nm，it was found that the color of the sample spots was more obvious in the branch than that in the main trunk when the R_f value was 0.38.The content determination results showed that the content of agarotetrol in Chenxiang（Aquilariae Lignum Resinatum）samples from different aroma forming parts ranged from 0.02% to 0.58%，and the average content of agarotetrol in the branches was higher than that in the stems.The characteristic spectrum results showed that there were 6 common characteristic peaks in the Chenxiang（Aquilariae Lignum Resinatum）sample，with a significant difference in the peak area of agarotetrol.Except for No.4，No.9，No.12 and No.13，the content of agarotetrol in the branches of the other groups was higher than that in the trunk.The similarity value of Chenxiang（Aquilariae Lignum Resinatum）trunk was between 0.842 and 0.999，and the similarity value of Chenxiang（Aquilariae Lignum Resinatum）branch was between 0.901 and 0.994，indicating a good branch similarity effect.The results of PCA and OPLS-DA analysis by chemometrics showed that peak 4 and peak 6 were the symbolic components of the quality difference of Chenxiang（Aquilariae Lignum Resinatum）aroma.

The present study comprehensively and effectively analyzed the chemical components of Chenxiang（Aquilariae Lignum Resinatum）samples obtained from the trunk and branch parts using TLC，content determination and characteristic chromatographic fingerprint analysis methods under the same artificial induction method.Apart from some samples showing significant individual differences，the Chenxiang（Aquilariae Lignum Resinatum）samples from the branch parts demonstrated more pronounced aroma effects，which provides a basis for future optimization of methods and in-depth research on aroma mechanisms.

To explore the effect of joint fumigation and washing instrument combined with Duhuo Jisheng Decoction（独活寄生汤）on knee joint function，pain and serum inflammatory factors in patients with knee osteoarthritis（KOA）.

Sixty patients were randomly divided into a control group and an observation group，30 cases in each group.The control group received intra-articular injection of sodium hyaluronate for treatment，while the observation group received joint fumigation and washing instrument combined with Duhuo Jisheng Decoction for treatment on the basis of the medication in the control group.The treatment period was 4 weeks.Traditional Chinese medicine syndrome scores，knee joint function，pain and serum inflammatory factor levels were compared between the two groups before treatment and 4 weeks after treatment.

There was no significant difference in traditional Chinese medicine syndrome scores between the two groups before treatment（P>0.05）.The scores decreased after treatment（P<0.05）and the degree of decrease in the observation group was greater than that in the control group（P<0.05）.There was no significant difference in Lysholm score，The Western Ontario and McMaster Universities（WOMAC）score or Hospital for Special Surgery（HSS）score between the two groups before treatment（P>0.05）.The Lysholm score and HSSscore increased after treatment compared to those before treatment（P<0.05），and the increase in the observation group was greater than that in the control group（P<0.05）.The WOMACscores decreased after treatment compared to those before treatment（P<0.05）and the decrease in the observation group was greater than that in the control group（P<0.05）.There was no significant difference in VAS score，levels of serum substance P（SP），5-hydrox-ytryptamine（5-HT），prostaglandin E2（PGE2），tumor necrosis factor-α（TNF-α），interleukin-6（IL-6），interleukin-10（IL-10），insulin-like growth factor 1（IGF-1）or transforming growth factor-β（TGF-β）between the two groups before treatment（P>0.05）.The VASscore decreased after treatment（P<0.05）and the degree of decrease in the observation group was greater than that in the control group（P<0.05）.The therapeutic effect of the observation group was significantly better than that of the control group（P<0.05）.

The joint fumigation and washing instrument combined with Duhuo Jisheng Decoction has significant effect on the treatment of KOA.It can effectively alleviate discomfort symptoms such as pain，inhibit pain and the levels of inflammatory factors，and improve knee joint function and treatment efficacy.