To observe the clinical efficacy of Liu's Zhenggu DanⅠ orally combined with Xiaozhong ointment externally on simple rib fractures.

Ninety patients with simple rib fractures admitted to Wuxi Hospital of Traditional Chinese Medicine from July 2024 to January 2025 were randomly divided into two groups at a 1∶ 1 ratio:the experimental group (treated with Liu's Zhenggu DanⅠ orally and Xiaozhong ointment externally) and the conservative treatment group (treated with Western medicine), with 45 patients in each group. On the 7th and 14th day after treatment, VAS scores and serum inflammatory factor levels at the fracture site were observed, and the formation of rib fracture callus was observed one month after treatment to evaluate the treatment effect.

On the 7th and 14th day after treatment, VAS scores and levels of IL -1β, IL -6, and TNF-αin the experimental group were significantly lower than those in the control group (P <0.05). In addition, the experimental group showed significant advantages in both rib fracture healing rate and clinical efficacy improvement rate. (P < 0.05).

The combination of oral administration of Liu's Zhenggu DanⅠ and external application of Xiaozhong ointment can alleviate patient pain, inhibit systemic inflammatory response, shorten the healing time of simple rib fractures, and have significant clinical efficacy. It can provide a new option for the treatment of simple rib fractures, enrich clinical treatment methods, and provide value for the modern clinical application of traditional Chinese medicine bone injury therapy.

To explore the clinical observation and effect of abdominal acupuncture therapy combined with Yangming meridian puncture in the treatment of diabetic peripheral neuropathy and nerve reflexes.

Selected 126 patients with diabetic peripheral neuropathy in the Department of Traditional Chinese Medicine, Xingtai Hospital of Traditional Chinese Medicine, from August 2022 to June 2024, grouped by the random number table method, 63 patients in the control group were treated with conventional medication + Yangming meridian rows of puncture therapy, and 63 patients in the experimental group were applied with abdominal acupuncture on the basis of the treatment in the control group, comparing the clinical effects of the two groups, evaluating the degree of symptomatic relief of the patients, the examination of the nerve conduction velocity determination, and the nerve reflexes. and nerve reflexes.

In this study, 1 case of 63 patients in the experimental group was excluded, 2 cases were shed, and 60 cases were finally included; 1 case of 63 patients in the control group was excluded, 1 case was shed, and 61 cases were finally included. The total effect rate of the experimental group was higher than that of the control group (P <0.05) ; there was no significant difference in the comparison of symptom scores, gastric emptying and BRU measurements, VPT and NCV of the lower limbs between the two groups before treatment (P > 0.05), and the symptom scores (limb numbness, pain, etc.) and the values of T1/2, BRU, and VPT were lower than those of the control group after the treatment of the experimental group(P <0.01), and the values of the peroneal nerve and the peroneal nerve's MNCV and SNCV were significantly higher than those of the control group (P > 0.05). The MNCV and SNCV values of peroneal nerve and common peroneal nerve were significantly higher than those of the control group (P <0.01) ; there was no significant difference in the scores of nerve reflexes before treatment between the two groups (P > 0.05) ; MDNS, NSS and MNSI scores of the experimental group were lower than those of the control group (P < 0.01).

The abdominal acupuncture therapy combined with the Yangming meridian puncture programme can effectively alleviate the clinical symptoms of patients with diabetic peripheral neuropathy, improve their gastric emptying function and bladder function, and enhance the nerve conduction velocity of the lower limbs of the patients, and reasonably optimize their nerve reflexes.

To observe the clinical efficacy of Huanglian Wendan Decoction in the treatment of pediatric multiple tic disorder (phlegm-heat-driven wind evidence).

The selected research subjects were 112 children with TS who were diagnosed and treated in Nantong Traditional Chinese Medicine Hospital from January 2024 to October 2024, and were randomly divided into an observation group and a control group with 56 cases each. During the treatment period, the children were instructed to have a regular schedule, eat properly, maintain a good emotional state, and avoid adverse stimuli. All children were given ear acupoint pressure bean therapy. On this basis, the control group was given oral tiapride tablets, while the observation group was given Huanglian Wendan Decoction in water. All children were treated continuously for 8 weeks. The condition improvement, TCM syndrome scores and serum dopamine (DA), Gamma-aminobutyric acid (GABA), norepinephrine (NE) levels before treatment, 2 weeks of treatment and 8 weeks of treatment were recorded and compared between the two groups. Compare the clinical efficacy of the two groups of children after 8 weeks of treatment.

Before treatment, there was no difference in YGTSS scores, TCM evidence points and serum DA, GABA, NE levels between the two groups of children (P >0.05). after 2 weeks and 8 weeks of treatment, the YGTSS scores, TCM syndrome integral and serum DA level of the two groups decreased, while the GABA and NE levels increased. And at each time point, the observation group was better than the control group. (P <0.05). After 8 weeks of treatment, the total effective rate was 92.86% (52/56) higher in the observation group than 73.21% (41/56) in the control group (P < 0.05).

Huanglian Wendan Decoction can effectively improve the tic symptoms of children with phlegm-heat and wind-driven TS, alleviate the children's TCM symptoms, and reduce the serum DA level, with remarkable clinical efficacy.

To observe the clinical efficacy of modified Shangqing powder with channel-guiding herbs in the treatment of acute migraine attacks.

A total of 47 patients with acute migraine attacks who visited the outpatient department of Encephalopathy at Dongzhimen Hospital, Beijing University of Chinese Medicine between July 2023 and June 2024 were selected and divided into Group A and B using a random number table method. In the first phase (P1), Group A received Shangqing powder combined with ibuprofen, while Group B received a placebo combined with ibuprofen. After a washout period, the two groups switched treatments in the second phase (P2). Each patient received both intervention methods sequentially. The effective rate of treatment, VAS scores and accompanying symptom scores before and 2 hours, 24 hours after treatment, and short-term recurrence of migraine within 24 h and 72 h after medication were observed. The possible target points were further explored by comparing the changes of serum indicators before and after treatment.

In the P1, there were significant between-group differences in accompanying symptom scores at 24 hours, VAS scores at 24 hours, and the degree of reduction in VAS scores at 24 hours (P < 0.05). The difference in serum nitric oxide (NO) levels before and after treatment also showed significant between-group differences (P < 0.05, P < 0.01). In the P2, there were no statistically significant differences in VAS scores at 2 hours and 24 hours or accompanying symptom scores between the groups(P > 0.05). Across both phases, the efficacy rate of Shangqing powder at 2 hours post-treatment was 72.20%, significantly higher than the placebo's 34.20% (χ² =10.716, P =0.001). Significant differences were observed in VAS scores at 24 hours and accompanying symptom scores at 2 hours and 24 hours post-treatment (P <0.05), and the migraine recurrence rate within 72 hours was reduced (P <0.01).

Shangqing powder demonstrates good clinical efficacy in the treatment of acute migraine attacks, providing clinical reference for the intervention of migraines with traditional Chinese medicine.

To study the effect of pharyngeal constrictor muscle strengthening training combined with traditional Chinese medicine rehabilitation on the feeding of food of different consistency in patients with swallowing disorders in the pharyngeal stage.

Ninety-five patients with swallowing disorders in pharyngeal stage included in our hospital from April 2022 to February 2024 were selected for observation, and grouped according to the randomized numerical table method. 47 cases in the study group received pharyngeal contraction muscle strengthening training combined with traditional Chinese medicine (TCM) rehabilitation, and 48 cases in the control group received pharyngeal contraction muscle strengthening training, and the results of clinical assessment of pharyngeal function were compared with those of the two groups, including the positive rate of the modified volumetric viscosity test (VVST-CV), the classification of the Functional Oral Intake Scale (FOIS), drinking test, and swallowing function clinical assessment results.

There was no difference in the results of FOIS and drinking test between the two groups before treatment (P >0.05), and after treatment, the FOIS grade of the study group was higher than that of the control group, but the drinking test grade was lower than that of the control group (P <0.01). There was no difference in the results of clinical assessment of swallowing function between the two groups before treatment (P >0.05), and after treatment, the incidence of effective cough was higher in the study group than in the control group, and the maximum respiratory time and the number of repeated salivary swallows were higher in comparison with the control group, but the time required for eating was less than that in the control group (P <0.01). The post-treatment positive rates of the study group for foods of different consistencies (No.1-3) were 29.79%, 14.89%, and 25.53%, respectively, all of which were lower than those of the control group, 64.58%, 45.83%, and 54.17% (P < 0.01).

For patients with swallowing disorders in the pharyngeal phase, transpharyngeal constrictor muscle strengthening training combined with Chinese medicine rehabilitation intervention is more effective, which can improve the swallowing function of patients eating food of different consistency, increase the effective cough, the longest respiratory time and the number of repeated salivary swallowing, and it is worth to be popularized and used in the clinic.

To investigate the efficacy of modified Dingchuan Decoction in treating children with cough variant asthma (CVA) of phlegm-heat accumulation in the lung syndrome and its effects on eosinophil (EOS) and serum amyloid A (SAA) levels.

From June 2021 to June 2024, a total of 104 children diagnosed with CVA (Phlegm-Heat Accumulation in the Lung Syndrome) who received treatment at Huai'an Traditional Chinese Medicine Hospital were randomly assigned into two groups: an observation group comprising 52 cases and a control group also consisting of 52 cases, with the assignment process conducted using a random number table method. The control group received a therapeutic regimen consisting of budesonide suspension administered via inhalation, complemented by montelukast sodium chewable tablets taken orally, while the observation group was treated with modified Dingchuan Decoction. After 1 week of treatment, traditional Chinese medicine syndrome scores, inflammatory factors (EOS and SAA), immune indicators (CD3⁺, CD4⁺, and CD8⁺), pulmonary function indices (FEV1 and FVC), clinical efficacy, and adverse reactions were compared between the two groups.

After treatment, traditional Chinese medicine syndrome scores, EOS, SAA, and CD8⁺ levels in the observation group and the control group decreased, with the observation group showing lower levels than the control group (P < 0.05). The CD3⁺, CD4⁺, FEV1, and FVC levels in both groups increased compared to before treatment (P <0.05). The observation group had higher levels than the control group (P <0.05). The treatment efficacy rate in the observation group was higher than that in the control group (P <0.05). During the treatment, no severe adverse reactions were observed in either group.

The modified Dingchuan Decoction is effective in treating children with CVA, which helps to suppress airway inflammation and improve the anti asthmatic effect of children, with good safety.

To observe the effect of Yangyin Runfei Qingzao Decoction combined with pirfenidone on patients with idiopathic pulmonary interstitial fibrosis.

A total of 100 patients with idiopathic pulmonary fibrosis were selected from Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine in Hebei Province. They were enrolled from September 2020 to September 2023. They were grouped by random number table method. 50 patients in pirfenidone group (1 case dropped, 49 cases eventually included) were given pirfenidone capsule treatment, and 50 patients in the combined Chinese medicine group (1 case dropped, 1 case excluded, 48 cases eventually included) were given pirfenidone capsule treatment. The pirfenidone group was treated with Yangyin Runfei Qingzao Decoction at the same time. After treatment, the clinical efficacy of the two groups was compared, the 6 min walking distance (6MWT) was measured before and after treatment, and the patients were evaluated with St. George's Respiratory Questionnaire (SGRQ) and idiopathic pulmonary fibrosis Patient Quality of Life Scale (ATAQ-IPF). The levels of total lung volume (TLC), arterial oxygen saturation (SaO₂), maximum mid-expiratory flow (MMF), and pulmonary carbon monoxide dispersion (DLco) were measured. Serum levels of IGFBP-5, CYFRA21-1, osteopontin, fibroblast growth factor (FGF -21), chemokine ligand 14 (CXCL14), malondialdehyde (MDA), glutathione peroxidase (GSH-Px), CD4⁺and CD8⁺ were detected.

The total effective rate of Chinese medicine combined group was higher than that of pirfenidone group (P <0.05). The expression levels of 6MWT, SGRQ score, TLC, SaO₂, FGF -21, MMF, GSH-Px, DLCO and CD4⁺ in Chinese medicine combined group were higher than those in pirfenidone group (P < 0.05). ATAQ-IPF score, CD8⁺, CXCL14, MDA, IGFBP-5, Cyfra21-1 and osteopontin expression in the Chinese medicine group were lower than those in pirfenidone group (P < 0.05).

The combination therapy of Yangyin Runfei Qingzao Decoction and pirfenidone in patients with idiopathic pulmonary fibrosis can reduce inflammation and oxidative injury, improve immune function, alleviate pulmonary fibrosis, and enhance patients' quality of life, exercise tolerance, and clinical efficacy.