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To observe the clinical efficacy of Huanglian Wendan Decoction in the treatment of pediatric multiple tic disorder (phlegm-heat-driven wind evidence).
The selected research subjects were 112 children with TS who were diagnosed and treated in Nantong Traditional Chinese Medicine Hospital from January 2024 to October 2024, and were randomly divided into an observation group and a control group with 56 cases each. During the treatment period, the children were instructed to have a regular schedule, eat properly, maintain a good emotional state, and avoid adverse stimuli. All children were given ear acupoint pressure bean therapy. On this basis, the control group was given oral tiapride tablets, while the observation group was given Huanglian Wendan Decoction in water. All children were treated continuously for 8 weeks. The condition improvement, TCM syndrome scores and serum dopamine (DA), Gamma-aminobutyric acid (GABA), norepinephrine (NE) levels before treatment, 2 weeks of treatment and 8 weeks of treatment were recorded and compared between the two groups. Compare the clinical efficacy of the two groups of children after 8 weeks of treatment.
Before treatment, there was no difference in YGTSS scores, TCM evidence points and serum DA, GABA, NE levels between the two groups of children (P >0.05). after 2 weeks and 8 weeks of treatment, the YGTSS scores, TCM syndrome integral and serum DA level of the two groups decreased, while the GABA and NE levels increased. And at each time point, the observation group was better than the control group. (P <0.05). After 8 weeks of treatment, the total effective rate was 92.86% (52/56) higher in the observation group than 73.21% (41/56) in the control group (P < 0.05).
Huanglian Wendan Decoction can effectively improve the tic symptoms of children with phlegm-heat and wind-driven TS, alleviate the children's TCM symptoms, and reduce the serum DA level, with remarkable clinical efficacy.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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