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Research Progress on Traditional Chinese Medicine Regulating Programmed Cell Death Pathways to Intervene in Sepsis-Induced Intestinal Dysfunction
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Yuanyuan LV1, 2, 3, Haoran YE1, 2, 3, Jin SONG1, 2, Jin CUI1, Shasha HE1, 2, 3, *
Acta Chinese Medicine and Pharmacology | 2026, 54(4) : 119 - 127
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Acta Chinese Medicine and Pharmacology | 2026, 54(4): 119-127
Research Progress on Traditional Chinese Medicine Regulating Programmed Cell Death Pathways to Intervene in Sepsis-Induced Intestinal Dysfunction
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Yuanyuan LV1, 2, 3, Haoran YE1, 2, 3, Jin SONG1, 2, Jin CUI1, Shasha HE1, 2, 3, *
Affiliations
  • 1.Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China
  • 2.Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China
  • 3.Beijing Key Laboratory of Basic Research on Traditional Chinese Medicine Infectious Diseases, Beijing 100010, China
Published: 2026-04-20 doi: 10.19664/j.cnki.1002-2392.260087
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Sepsis is a systemic inflammatory response syndrome triggered by infection, characterized by complex pathology, high treatment difficulty, and high mortality, making it one of the challenges in clinical treatment. Among its complications, intestinal dysfunction, as a common complication of sepsis, is not only a key factor leading to multiple organ dysfunction syndrome (MODS) but also often results in poor prognosis due to its insidious nature and suboptimal therapeutic efficacy, further increasing the complexity and urgency of treatment. Traditional Chinese medicine (TCM), with its holistic regulatory approach and multi-pathway, multi-target characteristics, offers new strategies for the treatment of sepsis-induced intestinal dysfunction. In terms of mechanistic research, programmed cell death (PCD) plays a critical role in the pathological process of intestinal dysfunction by mediating the death of immune cells and intestinal epithelial cells. In recent years, TCM's intervention in sepsis-induced intestinal dysfunction by regulating PCD pathways has garnered widespread attention. This article summarizes recent relevant literature to review the effects and mechanisms of TCM and its active components in improving sepsis-induced intestinal dysfunction through intervention in PCD pathways, aiming to provide references and basis for the clinical treatment of sepsis-induced intestinal dysfunction.

Sepsis  /  Intestinal dysfunction  /  Programmed cell death  /  Traditional Chinese medicine
Yuanyuan LV, Haoran YE, Jin SONG, Jin CUI, Shasha HE. Research Progress on Traditional Chinese Medicine Regulating Programmed Cell Death Pathways to Intervene in Sepsis-Induced Intestinal Dysfunction[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (4) : 119 -127 . DOI: 10.19664/j.cnki.1002-2392.260087
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Article Info
doi: 10.19664/j.cnki.1002-2392.260087
  • Receive Date：2024-11-03
  • Online Date：2026-09-17
  • Published：2026-04-20
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History
  • Received：2024-11-03
  • Revised：2025-08-29
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Affiliations
    1.Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China
    2.Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China
    3.Beijing Key Laboratory of Basic Research on Traditional Chinese Medicine Infectious Diseases, Beijing 100010, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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