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Research Progress on the Pathogenesis of Ischemic Stroke and Traditional Chinese Medicine Intervention Based on the JAK2/STAT3 Signaling Pathway
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Yaoyao LIU1, 2, Qi WANG1, 2, Ziwen HOU1, 2, Peng LI1, 2, *
Acta Chinese Medicine and Pharmacology | 2026, 54(4) : 112 - 118
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Acta Chinese Medicine and Pharmacology | 2026, 54(4): 112-118
Research Progress on the Pathogenesis of Ischemic Stroke and Traditional Chinese Medicine Intervention Based on the JAK2/STAT3 Signaling Pathway
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Yaoyao LIU1, 2, Qi WANG1, 2, Ziwen HOU1, 2, Peng LI1, 2, *
Affiliations
  • 1.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, and National Clinical Research Centre for Chinese Medicine Acupuncture and Moxibustion, Tianjin 301617, China
  • 2.Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Published: 2026-04-20 doi: 10.19664/j.cnki.1002-2392.260086
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Ischemic stroke (IS) is a disease caused by sudden blockage of cerebral blood vessels leading to brain tissue damage, resulting in irreversible local neurological deficits and seriously threatening patients' lives and health. Currently, there are no particularly effective clinical treatments for this disease. The Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway is a key pathway affecting the occurrence and development of IS. Traditional Chinese medicine (TCM) exerts neuroprotective effects by regulating the JAK2/STAT3 signaling pathway, which has become an emerging direction for exploring IS treatment. This article takes the JAK2/STAT3 signaling pathway as the starting point, comprehensively reviews the regulatory role of this signaling pathway in IS pathological processes such as inflammatory response, apoptosis, cell proliferation and differentiation, and angiogenesis, analyzes recent research progress on TCM regulation of this signaling pathway to intervene in IS, and explores the potential of TCM compounds and their active components in improving IS symptoms and promoting neurological function recovery, thereby revealing the targets of TCM action and providing theoretical references for clinical treatment of IS.

Ischemic stroke  /  JAK2/STAT3 signaling pathway  /  Mechanism of action  /  Traditional Chinese medicine  /  Research progress
Yaoyao LIU, Qi WANG, Ziwen HOU, Peng LI. Research Progress on the Pathogenesis of Ischemic Stroke and Traditional Chinese Medicine Intervention Based on the JAK2/STAT3 Signaling Pathway[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (4) : 112 -118 . DOI: 10.19664/j.cnki.1002-2392.260086
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Year 2026 volume 54 Issue 4
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Article Info
doi: 10.19664/j.cnki.1002-2392.260086
  • Receive Date：2024-11-19
  • Online Date：2026-09-17
  • Published：2026-04-20
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History
  • Received：2024-11-19
  • Revised：2025-08-23
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Affiliations
    1.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, and National Clinical Research Centre for Chinese Medicine Acupuncture and Moxibustion, Tianjin 301617, China
    2.Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
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