Glioma, as a common malignant tumor of the nervous system and one of the malignant tumors with the highest mortality rates globally, still faces the persistent clinical dilemma of low cure rate, high recurrence rate, and extremely poor prognosis to this day. Based on the theory of collateral diseases and the guiding ideology of "smoothly regulating the brain collaterals", this paper conducts in - depth research on the etiology and pathogenesis of glioma, and summarizes that the essence of its etiology and pathogenesis lies in marrow deficiency and collateral asthenia, while its manifestation is the damage to the brain collaterals by toxins. According to the theory that "the collaterals should be kept unobstructed for their normal function", the basic treatment principles are proposed as follows: tonifying the deficiency of the collaterals and replenishing essence and marrow; dispersing with acrid herbs to smooth the collaterals, resolving phlegm and removing blood stasis; freeing the collaterals to dissipate masses, expelling wind and detoxifying.

Glioma  /  Theory of collateral diseases  /  Regulating and unblocking brain collaterals  /  Deficiency of the marrow and the collaterals  /  Damage to the brain collaterals by toxins