To analyze and identify the chemical components of Guizhi Gancao Decoction（桂枝甘草汤）and its components migrating to blood after oral administration to rats using UHPLC-Q-Exactive Orbitrap MS method.

Chromatographic separation was carried out on XSelect HSST3 column（2.1 mm×150 mm，2.5μm）with gradient elution of acetonitrile-1% acetic acid solution as mobile phase at the flow rate of 0.3 mL/min. The column temperature was 35℃，and the detection was performed in positive and negative ion modes. The chemical components of Guizhi Gancao Decoction were analyzed according to the retention time，precise molecular weight，fragment ions，fragmentation pattern and comparison with the reference substances. By comparing the chromatographic and mass spectrometry information of blank plasma，medicated plasma and Guizhi Gancao Decoction samples，the components migrating to blood were analyzed.

A total of 68 chemical components were identified in Guizhi Gancao Decoction，including 30 flavonoids，16 triterpenoids，8 organic acids，5 aldehydes，3 coumarins and 6 other components. After oral administration of Guizhi Gancao Decoction，a total of 45 prototype components were identified in rat plasma.

The established UHPLC-Q-Exactive Orbitrap MSmethod can rapidly characterize the whole chemical composition of Guizhi Gancao Decoction and its components migrating to blood in rats，providing a basis for further study on the pharmacodynamic material basis and quality control of Guizhi Gancao Decoction.

To discuss the efficacy of Modified Xiyangshen Baihe Maidong Decoction（加味西洋参百合麦冬汤）on immune function and renal function impairment in patients with non-small cell lung cancer.

One hundred and fifty patients with non-small cell lung cancer admitted to the hospital from August 2021 to February 2023 were selected，and assigned to treatment group（Modified Xiyangshen Baihe Maidong Decoction plus chemotherapy，73 cases）and control group（chemotherapy，77 cases）. Then the clinical efficacy，TCM syndrome score，immune function，inflammatory factors and toxic and side effect were compared between two groups.

The overall response rate（ORR）and disease control rate（DCR）were 53.42%（39/73）and 82.19%（60/73）in the treatment group，which were higher than 29.87%（23/77）and 62.34%（48/77）in the control group，with statistical difference（P<0.05）. TCM syndrome score was lower in the treatment group than that in the control group after treatment（P<0.05）. The proportion of CD⁺₃，CD⁺₄ and CD⁺₄/CD⁺₈，and natural killer（NK）cells showed an increase in the treatment group after treatment，and was larger than that in the control group（P<0.05）. Serum levels of interleukin-6（IL-6），tumour necrosis factor-α（TNF-α）and C-reaction protein（CRP）were lower in the treatment group than those in the control group（P<0.05）. The main toxic side effects were grade I-Ⅲ. The incidence of nausea and vomiting，leukopenia and renal function impairment in the treatment group was lower than that in the control group（P<0.05），whereas no statistical difference was reported in the incidence of myelosuppression between two groups（P>0.05）.

Application of Modified Xiyangshen Baihe Maidong Decoction combined with chemotherapy in patients with non-small cell lung cancer can effectively alleviate the clinical symptoms，improve immune function，attenuate inflammation response and reduce toxic side effects such as renal impairment.

To explore the clinical effect of the treatment of facial seborrheic dermatitis with heat excess in lung and stomach syndrome with the combination of Liangxue Qingfei Decoction（凉血清肺汤）and nitrate yellow liniment wet application.

A total of 102 acial seborrheic dermatitis patients with heat excess in lung and stomach syndrome admitted to the hospital from January 2022 to January 2023 were retrospectively selected and divided into study group（51 cases）and conventional group（51 cases）according to random number table method. The conventional group was treated with nitrate yellow liniment wet application and the study group was treated with Liangxue Qingfei Decoction combined with nitrate yellow liniment wet application. The clinical efficacy of patients after treatment，the eczema area severity index（EASI），investigator's global assessment（IGA），matrix metalloproteinase-3（MMP-3），interleukin-1β（IL-1β）and the adverse reactions during treatment were compared.

After treatment，the TCM symptom scores of two groups were lower than those before treatment（P<0.05），and the score of the study group was lower than that of the conventional group（P<0.05）. The total effective rate of the study group and the conventional group was 94.12%（48/51）and 72.55%（37/51），respectively，and the rate of the study group was higher than that of the conventional group（P<0.05）. The IGA and EASI scores of two groups were lower after treatment. The levels of MMP-3 and IL-1βin the study group were lower than those in the conventional group（P<0.05），and the levels of MMP-3 and IL-1βin the study group were lower than those in the conventional group after treatment（P<0.05）. There was no significant difference in the adverse reaction rate between the two groups（P>0.05）.

Liangxue Qingfei Decoction combined with nitrate yellow liniment wet application can improve the clinical efficacy，relieve symptoms，reduce IGA and EASI scores and improve the level of serum inflammation in patients with facial seborrheic dermatitis.

To study the effect of acupuncture combined with traditional Chinese medicine decoction on knee osteoarthritis and its effect on serum inflammatory pain mediators.

From August 2020 to January 2022，80 patients with knee osteoarthritis in the Affiliated Hospital of Chengde Medical College were divided into two groups according to the random number table method，40 cases in the control group and 40 cases in the observation group. The control group was treated with fire acupuncture alone，and the treatment group was treated with acupuncture combined with traditional Chinese medicine decoction. After 8 weeks of treatment，the efficacy，the levels of inflammatory factors interleukin-1（IL-1），interleukin-6（IL-6）and tumor necrosis factor-α（TNF-α），knee joint pain and activity，osteoarthritis index and adverse reactions were compared between the two groups.

The total effective rate of the treatment group was 97.50%（39/40），which was significantly higher than that of the control group（80.00%，32/40），and the difference was statistically significant（P<0.05）. After treatment，the levels of inflammatory factors（IL-1，IL-6，TNF-α）in the two groups were significantly decreased（P<0.001），and the levels in the treatment group were significantly lower than those in the control group（P<0.001）. Before treatment，there was no significant difference in visual analogue scale（VAS），active activity and passive activity between the two groups（P>0.05）. After treatment，the VASscores of the two groups were significantly decreased，and the active activity and passive activity were significantly increased（P<0.001）. The VASscores，active activity and passive activity of the treatment group were significantly better than those of the control group（P<0.05）. There was no significant difference in Western Ontario and McMaster Universities Osteoarthritis Index（WOMAC）scores between the two groups before treatment（P>0.05）. After treatment，the WOMAC scores of the two groups decreased significantly（P<0.001），and the WOMAC score of the treatment group was significantly lower than that of the control group（P<0.05）. The incidence of adverse reactions in the treatment group and the control group was 7.50%（3/40）and 10.00%（4/40），and the difference was not statistically significant（P>0.05）.

The curative effect of acupuncture combined with traditional Chinese medicine decoction in the treatment of knee osteoarthritis is significant. It can reduce the levels of inflammatory factors and better relieve the pain of knee joint of knee joint，so as to improve the condition of knee joint.

To explore the clinical study of blood letting puncture combined with“Tongji”electroacupuncture in the treatment of lumbar disc herniation.

From January 2022 to January 2023，88 patients with lumbar disc herniation were selected from the acupuncture and moxibustion department of the hospital. According to the treatment method，the patients were divided into an observation group（48 cases）and a control group（40 cases）. The control group was treated with traditional conventional acupuncture，while the observation group was treated with blood letting puncture and“Tongji”electroacupuncture for lumbar disc herniation. The changes of pain visual analogue score（VAS），Japanese Orthopaedic Association（JOA）score，bradykinin（BK），substance P（SP），Fas-FasL factor in peripheral venous blood，clinical efficacy，and serum inflammatory factor interleukin-6（IL-6），tumor necrosis factor-α（TNF-α），C-reactive protein（CRP）and Oswestry disability index（ODI）before and after treatment between the two groups were observed and compared. There was no obvious difference in the levels of SP，BK or Fas-FasL between two groups before treatment（P>0.05）. After 7 and 14 days of treatment，the levels of SPand BK in the serum of the observation group were obvious lower than those of the control group（P<0.05）. After 7 and 14 days of treatment，there was no obvious difference in Fas-FasL between two groups（P>0.05）. There was no obvious difference in VASbetween two groups before treatment（P>0.05）. After 7 and 14 days of treatment，the VASscore of the observation group was obvious lower than that of the control group（P<0.05）. There was no obvious difference in JOA between two groups before treatment（P>0.05）. After 7 and 14 days of treatment，the JOA score of the observation group was obvious higher than that of the control group（P<0.05）. The total effective rate of the observation group（97.92%，47/48）was higher than that of the control group（82.50%，33/40），and the difference was obvious（P<0.05）. The levels of IL-6 and TNF-αin two groups before treatment. There was no obvious difference in CRP（P>0.05）. The levels of IL-6，TNF-αand CRPof the observation group after treatment were significantly reduced compared to those of the control group（P<0.05）. There was no obvious difference in ODI between two groups before treatment（P>0.05）. After treatment，the ODI score of the observation group was obvious lower than that of the control group（P<0.05）.

Acupuncture and blood letting puncture combined with“Tongji”electroacupuncture significantly improved the patients'quality of life，increased the levels of BK and SP，reduced treatment cycles and significantly lowered the levels of inflammatory factors.

To study the effect of dispersing lung and descending Qi acupuncture combined with Ditan Decoction（涤痰汤）on lung function in patients complicating pulmonary infection during the recovery period of ischemic stroke.

Eighty patients complicating pulmonary infection during recovery period of ischemic stroke admitted to the hospital from July 2022 to July 2023 were enrolled，and assigned into two groups using random number table method，each with 40 cases. The control group received conventional Western medicine and dispersing lung and descending Qi acupuncture. Based on this，the observation group added Ditan Decoction. Then the outcome criteria were compared between two groups，including clinical efficacy，clinical pulmonary infection score（CPIS），forced expiratory volume in the first second（FEV₁），maximum voluntary ventilation（MVV），peak expiratory flow（PEF），forced vital capacity（FVC），alveolar partial pressure of oxygen（PaO₂），potential of hydrogen（pH），partial pressure of carbon dioxide in artery（PaCO₂），cough score，sputum score，fatigue severity scale（FSS）score and incidence of adverse reactions.

No statistical difference was reported between two groups in CPIS，cough score，sputum score，FSS，PaO₂，pH，PaCO₂，FEV₁，MVV，FVC or PEF（P>0.05）. After treatment，the overall efficacy rate was 97.50%（39/40）in the observation group，which was higher than 85.00%（34/40）in the control group（P<0.05）. After 2 and 4 of treatment，CPIS，cough，sputum and FSSscores showed a reduction in both groups（P<0.05），and the reduction was more notable in the observation group than that in the control group（P<0.05）. After 2 and 4 weeks of treatment，an increase in PaO₂ as well as a decrease in PaCO₂ and pH were observed in two groups（P<0.05），and both improvements were more remarkable in the observation group than those in the control group（P<0.05）. An elevation in FEV₁，MVV，PEFand FVCwas measured in both groups after 2 and 4 weeks of treatment，and the elevation was more significant in the observation group than that in the control group（P<0.05）. The adverse reaction rate was 7.50%（3/40）in the observation group，which was slightly lower than 10.00%（4/40）in the control group，with no statistical difference（P>0.05）.

Application of dispersing lung and descending Qi acupuncture combined with Ditan Decoction on lung function in patients complicating pulmonary infection during the recovery period of ischemic stroke can effectively ameliorate the clinical symptoms，and has a good safety profile.

To investigate the effect of Wuzi Xiezhuo Decoction（五子泄浊汤）combined with acupuncture on glucose and lipid metabolism and ovulation rate in obese polycystic ovary syndrome.

Eighty cases of obese polycystic ovary syndrome were randomly divided into a control group and a study group，with 40 cases in each group. The control group was given Diane-35 and Metformin orally，and the study group was given Wuzi Xiezhuo Decoction combined with acupuncture at abdominal acupoints. The changes of glucose metabolism index，lipid metabolism index，sex hormone level and ovulation were observed before and after treatment.

The levels of fasting blood sugar（FBG），fasting insulin（FINS）and homeostasis model assessment-insulin resistance（HOMA-IR）before treatment in the study group and the control group were not significant（P>0.05）. The above indexes decreased after treatment compared with those before treatment，and the decline level in the study group was greater than that in the control group（P<0.05）. The levels of total serum cholesterol（TC），triacylglycerol（TG），high-density lipoprotein cholesterol（HDL-C）and low density lipoprotein cholesterol（LDL-C）in the two groups before treatment were compared（P>0.05）. The levels of TC，TG and LDL-C after treatment were lower than those before treatment，and the decline level in the study group was greater than that in the control group. The level of HDL-Cincreased compared to that before treatment，and the level of increase in the study group was higher than that in the control group（P<0.05）. Before treatment，the levels of follicle stimulating hormone（FSH），luteinizing hormone（LH），progesterone（P）and LH/FSH in the two groups were not significant（P>0.05）. After treatment，the levels of LH，P and LH/FSH decreased compared with those before treatment，and the decrease level in the study group was greater than that in the control group. After treatment，the FSH increased compared with that before treatment，and the increase level in the study group was greater than that in the control group（P<0.05）. Compared with that of the control group before treatment，the ovulation rate of the study group increased after treatment（P>0.05），and the level of increase in the study group was higher than that of the control group（P<0.05）.

The treatment of obesity polycystic ovary syndrome with Wuzi Xiezhuo Decoction combined with acupuncture is helpful to improve the disorder of glucose and lipid metabolism，further regulate the levels of sex hormones and increase the ovulation rate.

To observe the clinical effect of Wenpi Huayu Recipe（温脾化瘀方）combined with musk moxibustion on pancreatic cancer.

In this study，a total of 105 patients with pancreatic cancer（admitted from July 2020 to July 2023）were divided into two groups by random number table method. The patients in the control group（52 cases）received clinical symptomatic treatment and chemotherapy and those in the observation group（53 cases）received combined treatment with Wenpi Huayu Recipe and musk moxibustion on the basis of the treatment in the control group. During the study，1 case fell off in the control group and 1 case in the observation group. The data of each group was observed，including curative effect，TCM syndrome scores（abdominal lumps，limb coldness，overeating，limb edema，abdominal distension，etc），the levels of carcinoembryonic antigen and carbohydrate antigen 199（CA199）before and after treatment，the levels of interleukin-6（IL-6），interleukin-10（IL-10），tumor necrosis factorα（TNF-α）and other inflammatory factors，the levels of T lymphocyte subsets CD3⁺，CD4⁺，CD8⁺，adverse reactions and changes of Karnofsky performance status（KPS）before and after treatment.

The treatment effect of the observation group was better than that of the control group（P<0.05）. Before treatment，TCM syndrome scores（abdominal lumps，limb coldness，overeating，limb edema，abdominal distension，etc），the levels of CA199，IL-6，IL-10，TNF-α，CD3⁺，CD4⁺and CD8⁺and KPSscores were not significant in both groups（P>0.05）. After treatment，TCM syndrome scores（abdominal lumps，limb coldness，overeating，limb edema，abdominal distension，etc），levels of carcinoembryonic antigen and CA199，IL-6 and IL-10，TNF-αand CD3⁺，CD4⁺and CD8⁺of patients in all groups were decreased，and KPSscores were increased. Traditional Chinese medicine syndrome scores（abdominal mass，limb chills，lack of food，limb edema，abdominal dis-tension，etc.），levels of carcinoembryonic antigen，CA199，IL-6，IL-10 and TNF-αin observation group were lower than those in control group，and the levels of CD3⁺，CD4⁺and CD8⁺and KPS scores were higher than those in the control group（P<0.05）. The adverse reaction rate of the observation group was lower than that of the control group（P<0.05）.

Wenpi Huayu Recipe combined with musk moxibustion has good clinical effect in the treatment of pancreatic cancer，which can effectively inhibit tumor cells，relieve the symptoms，inhibit the body's inflammatory response，improve the body's immune capacity and quality of life，alleviate the adverse reactions of chemotherapy and ensure the treatment safety，and the treatment is worthy of application.

To study the effects of endoscopic mucosal dissection（ESD）endoscopic surgery combined with Yiwei Sijunzi Decoction（益胃四君子汤）on the serum regulatory function of mucosal repair and indicators such as glutathione peroxidase（GSH-Px），hypoxia inducible factor-1α（HIF-1α）and vascular endothelial growth factor（VEGF）in patients with precancerous lesions of chronic atrophic gastritis.

A retrospective analysis was conducted on 93 patients with chronic atrophic gastritis precancerous lesions admitted to the hospital. The patients were divided into two groups. The control group（46 cases）received Weifuchun Tablets（胃复春片），while the experimental group（47 cases）received Yiwei Sijunzi Decoction. The correlation between the mechanisms of gastric mucosal repair［epidermal growth factor（EGF），epidermal growth factor receptor（EGFR）］，angiogenesis（HIF-1α，VEGF），serum p53，malondialdehyde（MDA），GSH-Px and clinical efficacy were compared between the two groups before and after treatment.

After one month of treatment，the expressions of EGF，EGFR，HIF-1α and VEGF，and the serum levels of p53 and MDA in the experimental group were significantly lower than those in the control group，and the expression of GSH-Px was significantly higher than that in the control group（P<0.05）. The total therapeutic effect（76.09%，35/46）in the control group was significantly lower than that（91.49%，43/47）in the experimental group（P<0.05）.

ESD endoscopy combined with Yiwei Sijunzi Decoction can effectively reduce the overexpressions of gastric mucosal repair factors and angiogenic factors in patients with precancerous lesions of chronic atrophic gastritis，increase the expression of GSH-Px，and has good clinical efficacy.