To discuss the efficacy of Modified Xiyangshen Baihe Maidong Decoction（加味西洋参百合麦冬汤）on immune function and renal function impairment in patients with non-small cell lung cancer.

One hundred and fifty patients with non-small cell lung cancer admitted to the hospital from August 2021 to February 2023 were selected，and assigned to treatment group（Modified Xiyangshen Baihe Maidong Decoction plus chemotherapy，73 cases）and control group（chemotherapy，77 cases）. Then the clinical efficacy，TCM syndrome score，immune function，inflammatory factors and toxic and side effect were compared between two groups.

The overall response rate（ORR）and disease control rate（DCR）were 53.42%（39/73）and 82.19%（60/73）in the treatment group，which were higher than 29.87%（23/77）and 62.34%（48/77）in the control group，with statistical difference（P<0.05）. TCM syndrome score was lower in the treatment group than that in the control group after treatment（P<0.05）. The proportion of CD⁺₃，CD⁺₄ and CD⁺₄/CD⁺₈，and natural killer（NK）cells showed an increase in the treatment group after treatment，and was larger than that in the control group（P<0.05）. Serum levels of interleukin-6（IL-6），tumour necrosis factor-α（TNF-α）and C-reaction protein（CRP）were lower in the treatment group than those in the control group（P<0.05）. The main toxic side effects were grade I-Ⅲ. The incidence of nausea and vomiting，leukopenia and renal function impairment in the treatment group was lower than that in the control group（P<0.05），whereas no statistical difference was reported in the incidence of myelosuppression between two groups（P>0.05）.

Application of Modified Xiyangshen Baihe Maidong Decoction combined with chemotherapy in patients with non-small cell lung cancer can effectively alleviate the clinical symptoms，improve immune function，attenuate inflammation response and reduce toxic side effects such as renal impairment.