To observe the clinical effect of Wenpi Huayu Recipe（温脾化瘀方）combined with musk moxibustion on pancreatic cancer.

In this study，a total of 105 patients with pancreatic cancer（admitted from July 2020 to July 2023）were divided into two groups by random number table method. The patients in the control group（52 cases）received clinical symptomatic treatment and chemotherapy and those in the observation group（53 cases）received combined treatment with Wenpi Huayu Recipe and musk moxibustion on the basis of the treatment in the control group. During the study，1 case fell off in the control group and 1 case in the observation group. The data of each group was observed，including curative effect，TCM syndrome scores（abdominal lumps，limb coldness，overeating，limb edema，abdominal distension，etc），the levels of carcinoembryonic antigen and carbohydrate antigen 199（CA199）before and after treatment，the levels of interleukin-6（IL-6），interleukin-10（IL-10），tumor necrosis factorα（TNF-α）and other inflammatory factors，the levels of T lymphocyte subsets CD3⁺，CD4⁺，CD8⁺，adverse reactions and changes of Karnofsky performance status（KPS）before and after treatment.

The treatment effect of the observation group was better than that of the control group（P<0.05）. Before treatment，TCM syndrome scores（abdominal lumps，limb coldness，overeating，limb edema，abdominal distension，etc），the levels of CA199，IL-6，IL-10，TNF-α，CD3⁺，CD4⁺and CD8⁺and KPSscores were not significant in both groups（P>0.05）. After treatment，TCM syndrome scores（abdominal lumps，limb coldness，overeating，limb edema，abdominal distension，etc），levels of carcinoembryonic antigen and CA199，IL-6 and IL-10，TNF-αand CD3⁺，CD4⁺and CD8⁺of patients in all groups were decreased，and KPSscores were increased. Traditional Chinese medicine syndrome scores（abdominal mass，limb chills，lack of food，limb edema，abdominal dis-tension，etc.），levels of carcinoembryonic antigen，CA199，IL-6，IL-10 and TNF-αin observation group were lower than those in control group，and the levels of CD3⁺，CD4⁺and CD8⁺and KPS scores were higher than those in the control group（P<0.05）. The adverse reaction rate of the observation group was lower than that of the control group（P<0.05）.

Wenpi Huayu Recipe combined with musk moxibustion has good clinical effect in the treatment of pancreatic cancer，which can effectively inhibit tumor cells，relieve the symptoms，inhibit the body's inflammatory response，improve the body's immune capacity and quality of life，alleviate the adverse reactions of chemotherapy and ensure the treatment safety，and the treatment is worthy of application.