Latest ArticlesDahuang（Rhubarb）is a commonly used traditional Chinese medicine in ancient and modern clinical practice. By consulting the works of past generations of herbal medicine，the author combed the historical evolution and processing functions of Dahuang（Rhubarb）in ancient literature and documents，summarized the inclusion of Dahuang（Rhubarb）processing methods in the pharmacopoeia standards and national and provincial Chinese medicine processing specifications，and the modern research results of Dahuang（Rhubarb）processing technology，the influence of processing on chemical composition and pharmacological effects. It was found that there were many ancient processing methods，including purification，cutting，cannon roasting，wine processing（wine washing，wine immersion，wine steaming，wine stirring，wine simmering），honey processing，stir-frying，vinegar processing（vinegar decoction，vinegar steaming，vinegar simmering，vinegar boiling），simmering，children's urine processing，medicinal juice processing，swilling water processing，crisping and ginger production；the common modern processing methods are mainly purification，wine roasting，wine stewing or wine steaming，and stir-frying charcoal，significantly reduced compared with those in the ancient times. This article provided the reference for further research on the processing of Dahuang（Rhubarb）and the development of clinical processed products.
Parkinson's disease is a common neurodegenerative disease. Its incidence and mortality rates are increasing year by year. It has a great impact on the life of patients and a great burden on society. However，there is a lack of effective therapeutic drugs. Huanglian（Coptidis Rhizoma）is a traditional Chinese herbal medicine with a history of over two thousand years. It contains various active ingredients such as alkaloids，lignans，flavonoids，acidic components，etc. It has a multi-signal，multitarget and multi-pathway neuroprotective effect，such as anti-inflammatory，antioxidant stress，mitochondrial protection and other pharmacological effects. Huanglian（Coptidis Rhizoma）has shown good application prospects in neurodegenerative diseases such as cerebral ischemic injury，Alzheimer's disease，Parkinson's disease，Huntington's disease，epilepsy，etc. Huanglian（Coptidis Rhizoma）and its effective component，berberine，may exert neuroprotective effects through mechanisms such as antioxidant stress，mitochondrial protection，inhibition of neuroinflammation and inhibition of cell apoptosis. This article summarized the current research status of Parkinson's disease，the theoretical role of Huanglian（Coptidis Rhizoma）in preventing and treating Parkinson's disease，and the research progress of berberine in protecting dopamine neurons in the substantia nigra of the brain，providing a theoretical basis for Huanglian（Coptidis Rhizoma）in the clinical prevention and treatment of Parkinson's disease.
To observe the effects of Shenling Baizhu Powder（参苓白术散，SLBZP）and its separated components on glucose and lipid metabolism in obese type 2 diabetes mellitus（T2DM）rats induced by high-fat diet（HFD）combined with low-dose streptozotocin（STZ），so as to obtain the best effective part of SLBZP to improve obese T2DM，and to clarify the main material basis of SLBZP to treat T2DM with“sweet drugs”.
The obese T2DM rats were treated with SLBZP，its split components and liraglutide. The body weight，abdominal circumference，food intake，water intake and fasting blood glucose of rats were measured regularly，and oral glucose tolerance test（OGTT），insulin tolerance test（ITT）and pyruvate tolerance test（PTT）were performed after administration. Homeostasis model assessment of insulin resistance index（HOMA-IR），homeostasis model assessment ofβ-cell（HOMA-β），insulin sensitivity index（ISI），quantitative insulin sensitivity check index（QUICKI）and other parameters were calculated. At the end of the study，the serum and pancreatic tissue were collected for biochemical and pathological analysis.
The obese T2DM animal model was successfully established by HFD＋STZ.SLBZP and its split components can reduce the weight and abdominal circumference of obese T2DM rats，alleviate the phenotype of polyphagia and polydipsia in obese T2DM rats，and regulate lipid metabolism. It can reduce fasting blood glucose，improve glucose tolerance，insulin tolerance and pyruvate tolerance，islet morphology and function，and regulate glucose metabolism in obese T2DM rats.
SLBZPand its separated components can effectively improve obese T2DM，regulate the disorder of glucose and lipid metabolism，and repair the pathological damage of pancreas. Polysaccharide of SLBZP is the best effective part to improve obese T2DM. The polysaccharides faction，70% ethanol fraction and water eluted fraction of SLBZPare the main material basis of the“sweet”taste of SLBZP，which together play the role of SLBZPin improving obese T2DM.
Duhuo（Angelicae Pubescentis Radix）is a classic wind-dampness eliminating medicine with outstanding efficacy of eliminating wind-dampness and relieving paralysis and pain，which is widely used in the treatment of bone diseases. However，there are many varieties of Duhuo（Angelicae Pubescentis Radix）and its efficacy varies greatly，so the effectiveness of clinical use of the drug cannot be guaranteed. Standardizing the quality of Chinese herbal medicines is the basis for ensuring the safety and effectiveness of the clinical use of Duhuo（Angelicae Pubescentis Radix）. In this paper，it reviewed the current status of quality control of Duhuo（Angelicae Pubescentis Radix），pointed out the inadequacy of only using the contents of serpentin and dihydroparsinol angelic acid ester as the quality control standard，and at the same time，combined with the core concept of Quality Marker（Q-Marker），it predicted the Q-Marker from the aspects of phytopharmacology，chemical constituent peculiarities，traditional medicinal properties，the measurability of the chemical constituents，different compounding environments，different harvesting periods and preparation methods and new efficacies. The Q-Marker was used to predict the efficacy of Duhuo（Angelicae Pubescentis Radix）. The results revealed that the coumarin-like components，such as serpentin，dihydroeucalyptol angelate，isoeucalyptol，citronellolide，psoralen，eucalyptol and scopoletin，and volatile oils，such as eucalyptol methyl ether，α-myrcene alcohol，2-（diethylaminophenylmethyl）cyclohexyl alcohol，β-hydroxycaryophyllene，angelicin A and angelicin G could be used as the Q-Markers of Duhuo（Angelicae Pubescentis Radix），which provided a reference basis to set up a comprehensive and perfect quality control system for Duhuo（Angelicae Pubescentis Radix）.
Chronic obstructive pulmonary disease（COPD）in a stable stage complicated with pulmonary hypertension（PH）is a common comorbidity. It is a progressive disease and a key factor in the development of chronic pulmonary heart disease. Traditional Chinese medicine treatment offers unique advantages such as multiple levels，multiple targets and lower side effects. The stable stage is crucial for the prognosis of the disease. The method of“simultaneous treatment of heart and lung”was first created by ZHANG Zhongjing. The academic thought of“integration of heart and lung”was proposed by CHENG Songya by inheriting the experience of predecessors.“Simultaneous treatment of lung and heart”embodies“the integration of heart and lung”，which has profound ideas of addressing symptoms and root causes and preventing the disease from progressing. This paper is based on the physiological basis that the lung and heart are connected by the channel and“Qi and blood”；the lung and heart are located in the upper energizer and correspond to Yin and Yang；the lung and heart are maintained by Zongqi and associated with Ying and Wei. Clarifying the core pathogenesis of COPD complicated with PH involves the deficiency of lung and heart，endogenous phlegm and stasis. Treatment methods such as harmonizing the essence of Qi and blood，warming the movement of Yangqi，and cultivating and benefiting Zongqi，which are based the theory of“three talents of heaven-earth-man”and used to provide ideas and references for the clinical diagnosis and treatment process.
To explore the effect of Yishen Huayu Recipe（益肾化瘀方）combined with bioelectric stimulation on preventing recurrence after hysteroscopic intrauterine adhesion separation.
A total of 148 patients with severe intrauterine adhesions（admitted from June 2020 to June 2023）were included in the study and divided into observation group and control group by random number table method，with 74 cases in each group. The patients in the control group were treated with hysteroscopic intrauterine adhesions separation combined with simulated bioelectric stimulation. Those in the observation group were treated with Yishen Huayu Recipe on the basis of the treatment of patients in the control group. During the treatment，2 cases fell off in the control group and 3 cases fell off in the observation group. The data of each group was observed，including the efficacy，the postoperative complications，the total scores of TCM symptoms and uterine adhesion scores before and after treatment，uterine volume and endometrial thickness，pulse index（PI）and vascular resistance index（RI）before and after treatment，Pictorial Blood Loss Assessment Chart（PBAC）scores before surgery，1 and 2 months after surgery，recurrence rate of uterine adhesion and successful pregnancy rate 6 months after surgery.
The treatment effect of the observation group was better than that of the control group，and the postoperative complication rate was lower than that of the control group（P<0.05）. After treatment，the total scores of TCM symptoms，uterine adhesion score，uterine volume and endometrial thickness，PI and RI were improved in both groups，and the total scores of TCM symptoms，uterine adhesion score，uterine volume and endometrial thickness，PI and RI in the observation group were better than those in the control group（P<0.05）. The PBAC score of the observation group 1 and 2 months after operation was better than that of the control group（P<0.05）. The recurrence rate of intrauterine adhesions in the observation group was lower than that in the control group 6 months after operation，and the successful pregnancy rate was higher than that in the control group（P<0.05）.
Yishen Huayu Recipe combined with bioelectric stimulation can better improve the surgical effect of hysteroscopic intrauterine adhesion separation，prevent the recurrence of intrauterine adhesion，improve the clinical symptoms and uterine conditions of the patients，reduce the postoperative complications and increase the successful pregnancy rate，which is worthy of application.
To evaluate the application of Guizhi Longgu Muli Decoction（桂枝龙骨牡蛎汤）combined with repetitive transcranial magnetic stimulation in chronic obstructive pulmonary disease（COPD）with anxiety and depression.
A prospective study was conducted to select 98 COPD patients with anxiety and depression who received a systematic diagnosis and treatment plan，and to cooperate in completing the follow-up process. According to the random number table method，the patients were divided into two groups，with 49 cases in each group. The control group received repeated transcranial magnetic stimulation and continued to take it for 8 weeks. The observation group was given Guizhi Longgu Muli Decoction combined with repeated transcranial magnetic stimulation for 8 weeks. The clinical efficacy and adverse reactions were evaluated. The levels of interleukin-1β（IL-1β），interleukin-6（IL-6），C-reactive protein（CRP），self rating anxiety scale（SAS），self rating depression scale（SDS）before and after 8 weeks of treatment were compared.
The clinical efficacy of the control group was lower than that of the observation group，and the difference was statistically significant（P<0.05）. The levels of serum IL-1β，IL-6 and CRP in the control group after 8 weeks of treatment in the observation group［（32.81±5.80）ng/mL，（20.15±3.56）ng/mL，（8.46±2.15）mg/L］were higher than those in the observation group［（28.63±5.47）ng/mL，（14.08±3.12）ng/mL，（5.13±1.86）mg/L］，with statistical significance（P<0.05）. After 8 weeks of treatment，the SAS score［（49.81±1.63）points］and SDSscore［（52.10±1.22）points］in the control group were higher than those in the observation group［（48.42±1.56）points］and［（50.06±1.16）points］，with statistical significance（P<0.05）. There was no statistically significant difference in total adverse reactions between the two groups（P>0.05）.
Guizhi Longgu Muli Decoction combined with repeated transcranial magnetic stimulation can improve the symptoms of anxiety and depression in COPD patients with anxiety and depression，reduce inflammatory reaction，and has high safety.
To investigate the effects of Danhong Injection（丹红注射液）and levosimendan on the levels of n-terminal pro-brain natriuretic peptide（NT-proBNP），troponin I（cTnI）and hemodynamics in patients with septic cardiomyopathy.
A total of 85 patients with septic cardiomyopathy from January 2018 to October 2018 2023 divided into Group A（42 cases，treated with levosimendan）and Group B（43 cases，treated with Danhong Injection and levosimendan）according to different treatment methods，both groups were treated for two courses. The levels of NT-proBNPand cTnI were compared between the two groups before and after treatment，the hemodynamics indexes，cardiac function indexes and the levels of miR-133a，miR-499a-5p and miR-21-3 before and 24 h，48 h and 72 h after treatment were compared between the two groups.
After treatment，the levels of NT-proBNPand cTnI in both groups were lower than those before treatment，and the levels of NT-proBNP and cTnI in Group B were lower than those in group A after treatment. The TCM syndrome scores of main symptoms and secondary symptoms in both groups decreased，and the above scores in Group B were lower than those in group A. At different time points after treatment，the heart rate（HR）of patients in group B decreased compared to group A. With the prolongation of treatment time，HR decreased and mean arterial pressure（MAP）increased in both groups，left ventricular ejection fraction（LVEF）increased in both groups at different time points after treatment，the level of LVEF at 72 h in Group B was higher than that in Group A，and left ventricular end diastolic diameter（LVEDD）was higher in both groups at different time points after treatment than that before treatment. After treatment，the levels of miR-133A，miR-499a-5p and miR-21-3 in both groups were significantly lower than those before treatment，the above indexes in Group B were lower than those in Group A（all P<0.05）.
Danhong Injection combined with levosimendan in the treatment of patients with septic cardiomyopathy can effectively relieve the clinical symptoms，reduce the degree of myocardial damage and decrease the expression levels of miRNAs，help to improve hemodynamics indicators.
To observe the clinical efficacy of fire needle combined with cold stimulation of pharynx for the treatment of oropharyngeal dysphagia after stroke.
Eighty patients with oropharyngeal dysphagia after stroke who were admitted to the hospital from February 2020 to May 2023 were selected and randomly divided into cold stimulation group（40 cases，routine treatment＋cold stimulation）and fire needle group（40 cases，cold stimulation＋fire needle）by computer random number generator. The scores of TCM syndrome，swallowing function grade，swallowing function score，quality of life and nutritional status were compared before and after treatment in both groups. The clinical efficacy and adverse reactions were compared between the two groups.
After treatment，the scores of dysphagia，limb hemiplegia，tongue stiffness，dysarthria and total score，the percentage of swallowing function gradeⅢ，and the nutritional risk screening 2002 scale（NRS-2002）score in the fire needle group were lower than those in the cold stimulation group（P<0.05），while the percentage of swallowing function gradeⅠandⅡ，the swallowing function score and the swallowing disorder specific quality of life scale（SWAL-QOL）score in the fire needle group were higher than those in the cold stimulation group（P<0.05）. The total effective rate in the fire needle group was higher than that in the cold stimulation group（P<0.05）. No obvious adverse reactions were observed in both groups.
Fire needle combined with cold stimulation of pharynx can relieve oropharyngeal dysphagia after stroke，improve the treatment effect，quality of life and nutritional status of patients，and is safe and reliable.
To explore the efficacy of Bufei Yishen Qutan Naqi method combined with Budigefu（budesonide，glycopyrronium bromide and formoterol fumarate）in the treatment of patients with stable chronic obstructive pulmonary disease（COPD）of Yang deficiency and phlegm obstruction type.
A total of 95 patients with stable COPD were enrolled as the research subjects and were classified into control group（48 cases）and experimental group（47 cases）according to the random number table method. Both groups were given the basic treatment，and the control group was treated with Budigefu while the experimental group was given Bufei Yishen Qutan Naqi method＋Budigefu. Both groups were treated for 3 months. The TCM syndromes scores，pulmonary function［forced expiratory volume in the first second as a percentage of predicted value（FEVl%pred），FEVl/forced vital capacity（FVC），maximum mid-expiratory flow（MMEF），peak flow rate（PEF）］，airway remodeling indicators［matrix metalloproteinase（MMP）-9，tissue inhibitor of metalloproteinase（TIMP）-1，MMP-9/TIMP-1］，inflammatory indicators［interleukin（IL）-8，tumor necrosis factor（TNF）-α］，vascular endothelial function indicators［endothelin（ET），nitric oxide（NO）］and activity ability［six-minute walking test（6 MWT），modified Medical Research Council（mMRC）］were compared between both groups before and after treatment.
After 3 months of treatment，the scores of TCM syndromes，levels of serum IL-8，TNF-α，ET，MMP-9 and MMP-9/TIMP-1 were decreased in the two groups，and the decreases of the above indicators in the experimental group were higher than those in the control group（P<0.05）. The levels of FEV1%pred，FEV1/FVC，MMEF，PEF，serum NO and TIMP-1 and the distance of 6MWT were increased in both groups，and the increases were higher in the experimental group（P<0.05）.
Bufei Yishen Qutan Naqi method combined with Budigefu can effectively improve the endothelial function，reduce the airway remodeling，inhibit the inflammatory response，and then relieve the clinical symptoms，improve the pulmonary function，and promote the recovery of life activity ability in the treatment of stable COPD of Yang deficiency and phlegm obstruction type.
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