Full
Outline
To investigate the effects of Danhong Injection（丹红注射液）and levosimendan on the levels of n-terminal pro-brain natriuretic peptide（NT-proBNP），troponin I（cTnI）and hemodynamics in patients with septic cardiomyopathy.
A total of 85 patients with septic cardiomyopathy from January 2018 to October 2018 2023 divided into Group A（42 cases，treated with levosimendan）and Group B（43 cases，treated with Danhong Injection and levosimendan）according to different treatment methods，both groups were treated for two courses. The levels of NT-proBNPand cTnI were compared between the two groups before and after treatment，the hemodynamics indexes，cardiac function indexes and the levels of miR-133a，miR-499a-5p and miR-21-3 before and 24 h，48 h and 72 h after treatment were compared between the two groups.
After treatment，the levels of NT-proBNPand cTnI in both groups were lower than those before treatment，and the levels of NT-proBNP and cTnI in Group B were lower than those in group A after treatment. The TCM syndrome scores of main symptoms and secondary symptoms in both groups decreased，and the above scores in Group B were lower than those in group A. At different time points after treatment，the heart rate（HR）of patients in group B decreased compared to group A. With the prolongation of treatment time，HR decreased and mean arterial pressure（MAP）increased in both groups，left ventricular ejection fraction（LVEF）increased in both groups at different time points after treatment，the level of LVEF at 72 h in Group B was higher than that in Group A，and left ventricular end diastolic diameter（LVEDD）was higher in both groups at different time points after treatment than that before treatment. After treatment，the levels of miR-133A，miR-499a-5p and miR-21-3 in both groups were significantly lower than those before treatment，the above indexes in Group B were lower than those in Group A（all P<0.05）.
Danhong Injection combined with levosimendan in the treatment of patients with septic cardiomyopathy can effectively relieve the clinical symptoms，reduce the degree of myocardial damage and decrease the expression levels of miRNAs，help to improve hemodynamics indicators.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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