Full
Outline
To observe the effects of Shenling Baizhu Powder（参苓白术散，SLBZP）and its separated components on glucose and lipid metabolism in obese type 2 diabetes mellitus（T2DM）rats induced by high-fat diet（HFD）combined with low-dose streptozotocin（STZ），so as to obtain the best effective part of SLBZP to improve obese T2DM，and to clarify the main material basis of SLBZP to treat T2DM with“sweet drugs”.
The obese T2DM rats were treated with SLBZP，its split components and liraglutide. The body weight，abdominal circumference，food intake，water intake and fasting blood glucose of rats were measured regularly，and oral glucose tolerance test（OGTT），insulin tolerance test（ITT）and pyruvate tolerance test（PTT）were performed after administration. Homeostasis model assessment of insulin resistance index（HOMA-IR），homeostasis model assessment ofβ-cell（HOMA-β），insulin sensitivity index（ISI），quantitative insulin sensitivity check index（QUICKI）and other parameters were calculated. At the end of the study，the serum and pancreatic tissue were collected for biochemical and pathological analysis.
The obese T2DM animal model was successfully established by HFD＋STZ.SLBZP and its split components can reduce the weight and abdominal circumference of obese T2DM rats，alleviate the phenotype of polyphagia and polydipsia in obese T2DM rats，and regulate lipid metabolism. It can reduce fasting blood glucose，improve glucose tolerance，insulin tolerance and pyruvate tolerance，islet morphology and function，and regulate glucose metabolism in obese T2DM rats.
SLBZPand its separated components can effectively improve obese T2DM，regulate the disorder of glucose and lipid metabolism，and repair the pathological damage of pancreas. Polysaccharide of SLBZP is the best effective part to improve obese T2DM. The polysaccharides faction，70% ethanol fraction and water eluted fraction of SLBZPare the main material basis of the“sweet”taste of SLBZP，which together play the role of SLBZPin improving obese T2DM.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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