To evaluate the application of Guizhi Longgu Muli Decoction（桂枝龙骨牡蛎汤）combined with repetitive transcranial magnetic stimulation in chronic obstructive pulmonary disease（COPD）with anxiety and depression.

A prospective study was conducted to select 98 COPD patients with anxiety and depression who received a systematic diagnosis and treatment plan，and to cooperate in completing the follow-up process. According to the random number table method，the patients were divided into two groups，with 49 cases in each group. The control group received repeated transcranial magnetic stimulation and continued to take it for 8 weeks. The observation group was given Guizhi Longgu Muli Decoction combined with repeated transcranial magnetic stimulation for 8 weeks. The clinical efficacy and adverse reactions were evaluated. The levels of interleukin-1β（IL-1β），interleukin-6（IL-6），C-reactive protein（CRP），self rating anxiety scale（SAS），self rating depression scale（SDS）before and after 8 weeks of treatment were compared.

The clinical efficacy of the control group was lower than that of the observation group，and the difference was statistically significant（P<0.05）. The levels of serum IL-1β，IL-6 and CRP in the control group after 8 weeks of treatment in the observation group［（32.81±5.80）ng/mL，（20.15±3.56）ng/mL，（8.46±2.15）mg/L］were higher than those in the observation group［（28.63±5.47）ng/mL，（14.08±3.12）ng/mL，（5.13±1.86）mg/L］，with statistical significance（P<0.05）. After 8 weeks of treatment，the SAS score［（49.81±1.63）points］and SDSscore［（52.10±1.22）points］in the control group were higher than those in the observation group［（48.42±1.56）points］and［（50.06±1.16）points］，with statistical significance（P<0.05）. There was no statistically significant difference in total adverse reactions between the two groups（P>0.05）.

Guizhi Longgu Muli Decoction combined with repeated transcranial magnetic stimulation can improve the symptoms of anxiety and depression in COPD patients with anxiety and depression，reduce inflammatory reaction，and has high safety.