To investigate the effect of Yangyin Tongbi Jiejing Decoction（养阴通痹解痉汤）combined with functional training on hemiplegia after stroke.

A total of 108 patients with hemiplegia after stroke in the hospital were randomly divided into two groups with 54 patients in each group.The control group was given functional training，including regular turning over，positioning of the affected limb，sitting and sitting balance，sitting and standing transfer training，standing balance training，etc.The treatment group was given Yangyin Tongbi Jiezhu Decoction（1 dose/d）on the basis of the control group.The treatment time was 4 weeks.The therapeutic effect，TCM syndrome scores，Fugl-Meyer assessment scale（FMA），Barthel index（BI）Stroke-Specific Quality of Life Scale（SS-QOL），hemiplegic side knee joint，lower limb hip joint extension muscle strength，ankle dorsiflexion muscle strength，serum inflammatory factors and hemorheology index levels were compared after treatment.

After treatment，the total effective rate of the treatment group was higher（P<0.05）.After treatment，the Fugl-Meyer score，BI score and SS-QOL score，the extension muscle strength of hemiplegic knee joint，lower limb hip joint and the dorsiflexion muscle strength of ankle joint in both groups were significantly higher than those before treatment（P<0.05）.And these indexes of the treatment group increased more obviously（P<0.05）.After treatment，the levels of hematocrit（Hct），plasma fibrinogen（FIB）and plasma viscosity（PV），serum tumor necrosis factor alpha（TNF-α），interleukin6（IL-6）and hypersensitive C-reactive protein（hs-CRP），and TCM syndrome scores in both groups were significantly lower than those before treatment（P<0.05），and the decrease was significant in the treatment group（P<0.05）.

Yangyin Tongbi Jiejing Decoction combined with functional training has a good effect on patients with hemiplegia after stroke.

To analyze the effect of consciousness-restoring and orifice-opening acupuncture combined with brain-computer interface therapy on upper limb function in patients with spastic upper limb hemiplegia after cerebral infarction.

63 patients with upper limb spastic hemiplegia after cerebral infarction were divided into the control group（32 cases）and the combined group（31 cases）by random number table method.The control group was treated with brain-computer interface，and the combined group was treated with brain-computer interface combined with consciousness-restoring and orifice-opening acupuncture.Both groups were treated for 3 weeks.The neurological function deficit，activities of daily living，upper limb function，electrophysiology，vascular endothelial function of two groups before and after 3 weeks of treatment and the safety during treatment were compared.

Compared with those before treatment，after 3 weeks of treatment，the National institutes of health stroke scale（NIHSS）score，the serum levels of C-reactive protein（CRP）and endothelin（ET）in the two groups decreased，and the scores and levels were lower than those in the combined group（P<0.05）. Compared with those before treatment，after 3 weeks of treatment，the scores of Barthel index（BI），Fugl-meyer Motor function（FMA），Action research arm test（ARAT），WOLF motor function evaluation scale（WMFT）and serum nitric oxide（NO）levels increased in both groups，and those were higher in the combined group（P<0.05）. Compared with those before treatment，the motor evoked potential latency（MEP）and central motor conduction time（CMCT）of the two groups were shortened after 3 weeks of treatment，and the time of the combined group was shorter（P<0.05）.During treatment，the adverse reactions did not affect the course of treatment in both groups，and the incidence of adverse reactions was similar［16.13%（5/31）vs 9.38%（3/32），P>0.05］.

consciousness-restoring and orifice-opening acupuncture combined with brain-computer interface therapy could improve the upper limb function，reduce the nerve function defect and improve the ability of daily living in patients with upper limb spastic hemiplegia after cerebral infarction，which was analyzed that it is related to the regulation of electrophysiology and vascular endothelial function，and had good safety.

To investigate the clinical effect of Yinhua Qingdu Decoction（银花清毒汤）combined with acupuncture on dry eye caused by meibomian gland dysfunction（MGD）.

A total of 100 patients with MGD-induced dry eye admitted from January 2021 to December 2023 were included in this grouping trial.The patients were divided into Western medicine group（49 cases）and integrated traditional Chinese and Western medicine group（51 cases）by random number table method.All patients in the western medicine group were treated with metaromian gland massage and artificial tears.The patients in the integrated traditional Chinese and western medicine group were treated with meibomian gland massage and artificial tears，combined with the treatment of Yinhua Qingdu Decoction and acupuncture.The data of patients in each group was observed，including clinical treatment outcome，the changes in ocular function indexes（tear film rupture time and tear secretion，corneal fluorescence staining score），subjective dry eye symptom score，and ocular surface disease index before and after treatment，the ocular surface disease index（OSDI）score changes，the levesl of interleukin-10（IL-10）and interleukin-13（IL-13），the change of scores of National Eye Institute 25-Item Visual Function Questionnaire（NEI-VFQ-25）and adverse reactions.

The total effective rate of the integrated Chinese and western medicine group was significantly higher than that of Western medicine group（P<0.05）.Before treatment，the ocular function indexes（tear film rupture time and tear secretion volume，corneal fluorescence staining score），subjective dry eye symptom score，OSDI score，the levels of IL-10 and IL-13 and NEI-VFQ-25 score were not significant（P>0.05）.After treatment，the ocular function indexes（tear film rupture time and tear secretion volume，corneal fluorescence staining score），dry eye subjective symptom score，OSDI score，IL-10 and IL-13 levels，and NEI-VFQ-25 score were improved in all groups.After treatment，the ocular function indexes（tear film rupture time，tear secretion，corneal fluorescence staining score），subjective dry eye symptom score，OSDI score，the levels of IL-10 and IL-13 and NEI-VFQ-25 score in the integrated traditional Chinese and Western medicine group were improved better than those in Western medicine group（P<0.05）.The rate of adverse reaction was higher in both groups（P>0.05）.

The combination of Yinhua Qingdu Decoction and acupuncture in the treatment of dry eye caused by MGD has significant clinical effect，which can effectively reduce the inflammatory response of patients，improve the symptoms，eye function and visual quality of patients，and reduce the adverse reaction of treatment，and the treatment is safe and feasible.

To investigate the effects of Xiaoqinglong Decoction（小青龙汤）combined with glucocorticoids on pulmonary function and serum indexes in patients with bronchial asthma.

A total of 108 patients with bronchial asthma were selected and divided into two groups according to random number table method.The study group（54 cases）was treated with Xiaoqinglong Decoction combined with glucocorticoid，and the control group（54 cases）was treated with glucocorticoid.The clinical efficacy，TCM syndrome scores，lung function indexes［forced expiratory volume in first second（FEV1），forced vital capacity（FVC），forced expiratory flow at 50% of FVC exhaled（FEF50%），peak expiratory flow rate（PEF）］，laboratory indexes［C-reactive protein（CRP），serum transforming growth faction-β1（TGF-β1），Cellular signal transduction molecules-3（Smad-3）］and adverse reactions of the two groups were compared.

The total effective rate of the study group was higher than that of the control group（P<0.05）.After treatment，the scores of cough，wheezing，sputum and headache in both groups were decreased（P<0.05），and the scores in the study group were lower than those in the control group（P<0.05）.After treatment，the values of FEV1，FVC，FEF50% and PEF of the study group were increased（P<0.05），and the values of the study group were higher than those of the control group（P<0.05）.After treatment，the levels of CRP，TGF-β1 and SAMad-3 in both groups were decreased（P<0.05），and the levels of in the study group were lower than those in the control group（P<0.05）.There was no significant difference in the incidence of adverse reactions between the two groups（P>0.05）.

Xiaoqinglong Decoction combined with glucocorticoid therapy in patients with bronchial asthma can improve lung function indexes andreduce the levels of TGF-β1 and SAMAD-3，with good efficacy and safety.

To explore the therapeutic effect of Xiaoer Feire Kechuan Granules（小儿肺热咳喘颗粒）combined with vitamin D in the treatment of mycoplasma pneumoniae pneumonia in children.

A total of 302 children with mycoplasma pneumoniae pneumonia（admitted from October 2021 to December 2022）were included in the study and divided into control group and observation group by random number table method，with 151 cases in each group.The children in the control group received conventional Western medicine treatment and supplemented with vitamin D treatment.Those in the observation group were treated with Xiaoer Feire Kechuan Granules on the basis of medication in the control group.During the treatment and study，9 cases fell off in the control group and 10 cases fell off in the observation group.The clinical data of children in each group was compared，including the clinical efficacy，the changes in TCM symptom scores（fever，chest tightness and distension，cough and asthma，yellow phlegm not easy to cough up，body heat sweating，etc.）before and after treatment，time for fever to disappear，time for cough to disappear，time for sputum relief，time for lung moist rale to disappear，changes in lung function indicators，inflammation and immune-related indicators，and adverse reactions.

The clinical effect of the observation group was better than that of the control group（P<0.05）. Compared with that of the control group，the disappearance time of fever，cough，sputum relief and pulmonary moist rales was shorter in the observation group（P<0.05）.After treatment，TCM symptom scores（fever，chest tightness and distension，cough and asthma，yellow phlegm not easy to cough up，body heat sweating，etc.）in two groups were lower.The values of forced vital capacity（FVC），forced expiratory volume in one second（FEV1），FEV1/FVC and other pulmonary function indicators of two groups were significantly increased.The levels of C-reactive protein，CRPand procalcitonin（PCT）and other inflammatory indicators were decreased.The levels of immunoglobulin A（IgA），immunoglobulin G（IgG），immunoglobulin M（IgM）and other levels were all increased，and the scores of TCM symptoms（fever，chest tightness and distension，cough and asthma，yellow phlegm not easy to cough up，body heat and sweat，etc.）and inflammatory indicators（PCT and CRP）in the observation group were lower than those in the control group after treatment.The pulmonary function indexes（FVC，FEV1，FEV1/FVC）and immune indexes（IgA，IgG，IgM）were higher than those of the control group（P<0.05）.The adverse reaction rate of the observation group was lower than that of the control group（P<0.05）.

Xiaoer Feire Kechuan Granules combined with vitamin D has good curative effect in the treatment of mycoplasma pneumoniae pneumonia in children，with alleviated symptoms，rapid recovery，reduced inflammation，improved immune function and lung function and less adverse reactions，and the treatment is safe and reliable.

To define“sweetness”in traditional Chinese medicine based on sweet taste receptors and explore the hypoglycemic mechanism of Yuzhu（Polygonatum odoratumin）saponin.

The diabetic model was established by streptozocin（STZ）method. After successfully modeling，the mice were randomly divided into model group，metformin group，low dose of Yuzhu（Polygonatum odoratumin）saponin group，high dose of Yuzhu（Polygonatum odoratumin）saponin group，low dose of Yuzhu（Polygonatum odoratumin）saponin＋Lac（Lactisole）group and high dose of Yuzhu（Polygonatum odoratumin）saponin＋Lac group. The mice without modeling were taken as the normal group. Fasting blood glucose and glucose tolerance were tested 7 weeks after administration of the drug. After 8 weeks of drug administration，the levels of total cholesterol（TC），triglyceride（TG），low-density lipoprotein cholesterol（LDL-C）and high-density lipoprotein cholesterol（HDL-C）were determined by biochemical kits. The morphology of pancreas and liver tissues were observed by hematoxylin-eosin staining（HE），and the contents of glucagon-like peptide-1（GLP-1）and insulin were determined by enzyme linked immunosorbent assay（ELISA）. HuTu-80 was used as a cellular model，and the contents of GLP-1 and Cyclic adenosine monophosphate（cAMP）were detected by ELISA. The intensity of Ca^2＋fluorescence was detected by laser confocal.

Yuzhu（Polygonatum odoratumin）saponin significantly reduced the levels of fasting blood glucose，TC，TG and LDL-C in diabetic mice（P<0.05）. Yuzhu（Polygonatum odoratumin）saponin increased the levels of HDL-C，GLP-1 and insulin（P<0.05），and improved the morphology of the pancreas and liver tissues. Yuzhu（Polygonatum odoratumin）saponin significantly increased the contents of cAMP，Ca^2＋and GLP-1 after their action on cells（P<0.05）. However，the action of Yuzhu（Polygonatum odoratumin）saponin could be significantly inhibited by the sweet taste receptor inhibitor Lactisole（P<0.05）.

Yuzhu（Polygonatum odoratumin）saponin agitates sweet taste receptors due to the sweet taste，which in turn promotes GLP-1 secretion and exerts hypoglycemic effects.

To observe the effects of acupotomy intervention on the morphology of cervical muscle tissue，and the contents of cytokine and neuropeptide in rabbits with cervical spondylosis.

Thirty 6-month-old male New Zealand rabbits of ordinary health were randomly divided into acupotomy group，model group and blank group，with 10 rabbits in each group. The rabbits in the model and acupotomy groups were fixed in a head-down posture in a model box with ice packs applied to the neck once a day for 5 hours，continuing for 4 weeks to establish a cervical spondylosis model. After successful model establishment，the blank group and model group were raised under normal conditions，while the acupotomy group received acupotomy interventions at the cervical spinous processes and the areas of muscle nodules and cord-like sensations in the neck muscles，once a week for a total of three times. One week after the intervention，the posterior neck muscles and serum of the rabbits were collected. The morphological changes in the neck muscles were observed under a light microscope using HE staining. The serum cytokines［tumor necrosis factor-α（TNF-α），interleukin-1β（IL-1β），interleukin-6（IL-6），interleukin-8（IL-8）］were detected by ELISA and neck muscle neuropeptides（substance P，bradykinin）were detected by immunohistochemistry.

The sections from the model group revealed significant pathological changes under light microscopy，including disorderly degeneration alignment of muscle cells，edema，twisted and fractured muscle fibers，and extensive infiltration of inflammatory cells. The acupotomy group showed significant improvement in the structure of the neck muscles，with muscle fibers arrangement resembling that of the blank group，indicating that the acupotomy intervention could effectively restore the morphology of the damaged rabbit neck muscles and reduce inflammation levels. The levels of TNF-α，IL-1β，IL-6，IL-8，substance P and bradykinin in the model group were significantly higher than those in the blank group（P<0.05）. The levels of TNF-α，IL-1β，IL-6，IL-8，substance Pand bradykinin in the acupotomy group were significantly lower than those in the model group（P<0.05）.

Acupotomy therapy can reduce the levels of inflammatory mediators（TNF-α，IL-1β，IL-6，IL-8），and regulate the contents of substance P and bradykinin，alleviate inflammation and pain，and effectively promote the repair of damaged neck muscles.