To analyze the effect of consciousness-restoring and orifice-opening acupuncture combined with brain-computer interface therapy on upper limb function in patients with spastic upper limb hemiplegia after cerebral infarction.

63 patients with upper limb spastic hemiplegia after cerebral infarction were divided into the control group（32 cases）and the combined group（31 cases）by random number table method.The control group was treated with brain-computer interface，and the combined group was treated with brain-computer interface combined with consciousness-restoring and orifice-opening acupuncture.Both groups were treated for 3 weeks.The neurological function deficit，activities of daily living，upper limb function，electrophysiology，vascular endothelial function of two groups before and after 3 weeks of treatment and the safety during treatment were compared.

Compared with those before treatment，after 3 weeks of treatment，the National institutes of health stroke scale（NIHSS）score，the serum levels of C-reactive protein（CRP）and endothelin（ET）in the two groups decreased，and the scores and levels were lower than those in the combined group（P<0.05）. Compared with those before treatment，after 3 weeks of treatment，the scores of Barthel index（BI），Fugl-meyer Motor function（FMA），Action research arm test（ARAT），WOLF motor function evaluation scale（WMFT）and serum nitric oxide（NO）levels increased in both groups，and those were higher in the combined group（P<0.05）. Compared with those before treatment，the motor evoked potential latency（MEP）and central motor conduction time（CMCT）of the two groups were shortened after 3 weeks of treatment，and the time of the combined group was shorter（P<0.05）.During treatment，the adverse reactions did not affect the course of treatment in both groups，and the incidence of adverse reactions was similar［16.13%（5/31）vs 9.38%（3/32），P>0.05］.

consciousness-restoring and orifice-opening acupuncture combined with brain-computer interface therapy could improve the upper limb function，reduce the nerve function defect and improve the ability of daily living in patients with upper limb spastic hemiplegia after cerebral infarction，which was analyzed that it is related to the regulation of electrophysiology and vascular endothelial function，and had good safety.