Latest ArticlesTo investigate the efficacy of Longxuejie（Resina Draconis）combined with fluorouracil injection in patients with keloid scarswith different transforming growth factor-β（TGF-β）single nucleotide polymorphisms.
A total of 240 cases of keloid patients admitted to the hospital from July 2019 to January 2022 were included，which were categorized into wild group（wild-type TGF-β）and mutant group（mutant TGF-β）based on TGF-β single nucleotide polymorphisms，and themutant group was divided into rs747857 group（rs747857-type TGF-β），rs1800469 group（rs1800469 type TGF-β）and rs2241716 group（rs2241716 type TGF-β）. Five groups were treated with fluorouracil injection monotherapy or Longxuejie（Resina Draconis）combined with fluorouracil injection. The patients in the five groupswere scored by the Vancouver Scar Scale（VSS），the Patient and Observer Scar Assessment Scale（POSAS）and the Dermatologic Quality of Life Index（DLQI）scale before treatment and 12 months after the first treatment.
Compared with those of the wild group，the expression levels of TGF-β mRNA in themutation group，rs747857 group，rs1800469 group and rs2241716 group increased（P<0.05）. Compared with the wild group，the patients in the mutation group，rs1800469 group and rs2241716 group under monotherapy showed a significant increase in the total VSSscore and the total POSAS score after treatment（P<0.05）；whereas，compared with monotherapy，the patients in the mutation group，rs1800469 group and rs2241716 group under the combination therapy showed a significant decrease in the total VSS score and the total POSAS scores were significantly decreased（P<0.05）. Compared with thewild group，the patients in the rs2241716 group all showed a significant increase in DLQI scale scores after treatment（P<0.05）；whereas，compared with monotherapy，the patients in the rs2241716 group under combination therapy all showed a significant decrease in DLQI scale scores after treatment（P<0.05）. Compared with the wild group，the patients in the rs1800469 and rs2241716 groups showed a significant decrease in the effective rate after treatment（P<0.05）；while compared with mono therapy，the patients in the rs1800469 and rs2241716 groups under combination therapy showed a significant increase in the effective rate after treatment（P<0.05）. Compared with the wild group，the patients in the mutation group，rs1800469 group and rs2241716 group had delayed the first apparent effect and the number of fluorouracil times to reach the first apparent effect（P<0.05）；while compared with the monotherapy，the patients in the mutation group，rs1800469 group and rs2241716 group under the combination therapy had advanced the first apparent effect and the number of fluorouracil times to reach the first apparent effect（P<0.05）. Fewer total adverse reactions were observed in the wild，mutant，rs747857，rs1800469 and rs2241716 groups under combination therapy compared with monotherapy（P<0.05）.
Longxuejie（Resina Draconis）combined with fluorouracil injection has better efficacy and fewer adverse effects in patients with keloids with different TGF-β single nucleotide polymorphisms.
Gout is a recurrent metabolic disease with abnormal purine content and/or uric acid concentration in the body. The common clinical manifestation of gout is gouty arthritis（GA），which is a series of inflammatory reactions（heterologous diseases）caused by the accumulation of monosodium urate crystals（MSU）in surrounding tissues such as joint capsules，cartilage，synovium，etc. Nuclear factor-κB（NF-κB）signaling pathway，as an important mechanism of inflammation，is highly expressed in gout. Activated upstream receptors induce cells to produce tumor necrosis factor-α（TNF-α），interleukin-6（IL-6），interleukin-1β（IL-1β）and other pro-inflammatory factors through NF-κB signaling pathway. This leads to inflammation. Traditional Chinese medicine（TCM）has a long history in the prevention and treatmentof gout，with definite clinical efficacy and few side effects，and has the characteristics and advantages of multi-targets and extensive sources. According to the research athome and abroad，it is found that traditional Chinese medicine and its active ingredients could reduce the production of inflammatory factors，improve the inflammatory response and alleviate the attack of gout by regulating the NF-κB signaling pathway. In order to supplement the scientific nature of clinical medication and explore its pharmacological mechanism，this article reviewed the latest research results and mechanism of traditional Chinese medicine and active ingredients in the treatment of gout by regulating NF-κB signaling pathway by referring to relevant domestic and foreign literature，in order to provide scientific ideas for the clinical application of traditional Chinese medicine and provide reference for promoting the development of new drugs.
Yinyanghuo（Epimedii Folium）is a traditional tonic traditional Chinese medicine. It has significant biological functional activity and a wide range of pharmacological effects on many major organs and tissues of the human body. Themain chemical constituents of Yinyanghuo（Epimedii Folium）are flavonoids，lignans，alkaloids，volatile oils and other trace elements. Flavonoids are the main active ingredients and have significant immunomodulatory effects on the body. The immunomodulatory effects of flavonoids such as icariin（ICA），icaritin（ICT），dehydrated icariin（AHI），icariside I（ICA I），icariin polysaccharide（EPS）and total flavonoids of icariin（EFC）have been widely reported in recent years. A number of studies have shown that the above components have significant regulatory effects on immune organs，immune cells（includingmacrophages，T lymphocytes，B lymphocytes，NK cells，LAK cells，CD3AK cells，etc.），immune factors and tumor immune microenvironment. In recent years，with the continuous deepening of clinical observation and experimental research on the regulation of immune function by Yinyanghuo（Epimedii Folium），it has provided a scientific basis for improving the immune function of the body by traditional Chinese medicine. In this paper，the research status of Yinyanghuo（Epimedii Folium）regulating immune function was reviewed in order to provide reference for the study of the immunomodulatory effect of Yinyanghuo（Epimedii Folium）or other tonic Chinese medicines.
To explore the curative effect of Modified Gegen Qinlian Decoction（加味葛根芩连汤）and its influences on immune function in patients with recurrentoral ulceration（ROU）.
According to simple randomization method，they were divided into observation group and control group，56 cases in each group. The control group was treated with Kangfuxin Solution，while the observation group was treated with Modified Gegen Qinlian Decoction for 8 weeks. The curative effect and the number of oralulceration in the two groups were recorded. The ulceration pain［Visual analogue scale（VAS）］，the scores of TCM syndromes，the levels of inflammatory cytokines［Interleukin（IL）-1β，IL-17，IL-10，tumor necrosis factor-α（TNF-α）］in peripheral blood，cellular immune function（CD3+，CD4+，CD8+），quality of life［World health organization quality of life scale（WHOQOL-100）］and adverse reactions in the two groups were evaluated. All were followed up for 8 weeks after treatment to evaluate recurrence rates.
The total response rate of the observation group was higher than that of the control group（P<0.05）. After treatment，the scores of TCM syndromes and the number of ulceration in the observation group were lower than those in the control group（P<0.05）. After 4 and 8 weeks of treatment，the levels of serum IL-1β，IL-17，IL-10 and TNF-α were decreased in both groups，which were lower in the observation group than those in the control group，and the above serum indexes were the lowest in the observation group after 8 weeks of treatment（P<0.05）. After 4 and 8 weeks of treatment，the levels of CD3+and CD4+were increased，while CD8+levelwas decreased in both groups. The levels of CD3+and CD4+in the observation group were higher than those in the controlgroup，while CD8+level was lower than that in the control group. After8 weeks of treatment，the levels of CD3+ and CD4+ were the highest，while CD8+ level was the lowest in the observation group（P<0.05）. As the treatment time changed，VAS score was gradually decreased，and WHOQOL-100 score was gradually increased in both groups. After 2，4，6 and 8 weeks of treatment，VAS scores in the observation group were lower than those in the control group，and WHOQOL-100 scores were higher than those in the control group（P<0.05）. There was no significant difference in the incidence of adverse reactions between the two groups（P>0.05）. The recurrence rate in the observation group was lower than that in the control group（P<0.05）.
Modified Gegen Qinlian Decoction can not only improve the clinical curative effect，relieve inflammatory response and pain，butalso improve the immune function and quality of life，and reduce the recurrence rate in ROU patients，with high safety.
To study the effect of postoperative acupuncture intervention on Mini-mental state examination（MMSE）score and recovery time in elderly patientswith lower extremity surgery in department of orthopedics.
A total of104 elderly patients undergoing lower limb surgery in orthopedics department of the hospital from January to December 2022 were selected as the research objects. They were divided into two groups according to the random number tablemethod，with 52 cases in each group. The control group was treated with surgery under combined spinal-epidural anesthesia，and the observation group was treated with postoperative acupuncture intervention on the basis of the control group. The vital signs，recovery time，MMSE score，hemorheology and adverse reactions of the two groupswere observed and compared.
There was no significant difference in body temperature，heart rate or blood pressure between the observation group and the control group at1 and 3 days after operation（P>0.05）. The postoperative recovery time of the observation group was significantly shorter than thatof the control group（P<0.05）. After operation，the MMSE score of the control group decreased significantly，and there was no significant change in the observation group. The MMSE score of the observation group was significantly higher than that of the control group（P<0.05）. Before operation，there was no significant difference in high or low shear whole blood viscosity，plasma viscosity，hematocrit and erythrocyte aggregation indexes between the two groups（P>0.05）. After operation，the above hemorheology indexes of the two groups decreased significantly，and those in the observation group were lower than those in the control group（P<0.05）. The incidence of adverse reactions in the observation group and the control group was 3.85%（2/52）and 15.38%（8/52），and the incidence of the observation group was significantly lower than that of the control group（P<0.05）.
Postoperative acupuncture intervention is satisfactory for the elderly patients undergoing lower limb surgery in orthopedics. It can promote the recovery of patients，protect their cognitive function，improve the hemorheology，reduce the occurrence of adverse reactions，and facilitate the rehabilitation of the patients.
To investigate the effectof Dingkun Pill（定坤丹）combined with electrical stimulation therapy on endometrialmorphology and ovulatory function in infertility women with thin endometrium.
One hundred and six infertility women with thin endometrium admitted to the hospital from October 2020 to October 2022 were collected and randomly grouped，each with 53 cases. The control group was treated with electrical stimulation therapy. Based on this，the study group added Dingkun Pill. Then the clinical outcome，endometrial morphology（type A，B，C），endometrial thickness，follicular development，pulsatility index（PI），resistance index（RI），luteinizing hormone（LH），oestradiol（E2），follicle-stimulating hormone（FSH），clinical pregnancy rate，human chorionic gonadotropin（HCG）positive rate，live birth rate and early miscarriage rate were compared between groups.
The overall efficacy rate was 92.45% in the study group，which was higher than 77.36% in the control group（P<0.05）. An increase in percentage of endometrial morphology type A，and a decrease in percentage of type B and Cwere observed in all patients，and the improvements were more notable in the study group than those in the control group（P<0.05）. The endometrial thickness and diameter of dominant follicles showed an increase in all patients，and the increase was more remarkable in the study group than that in the control group（P<0.05）. The values of PIand RIdecreased in all patients after treatment，and the two indiceswere lower in the study group than those in the control group（P<0.05）. An increase in E2，and a decrease in LH and FSH were detected in all patients after treatment，and both changes were more significant in the study group than those in the control group（P<0.05）. The study group reported a higher clinical pregnancy rate and HCG positive rate than the controlgroup（P<0.05），and no statistical difference was found in earlymiscarriage rate and live birth rate between two groups（P>0.05）.
The application of Dingkun Pill combined with electrical stimulation therapy in infertility women with thin endometrium can effectively improve endometrial morphology and ovulatory function，and thus increasing the pregnancy rate.
To study the influence of Huanglian Jiedu Decoction（黄连解毒汤）on cognitive function and expressions of serum human amyloid β-protein 1-42（Aβ1-42）and bradykinin（BK）in patients with Alzheimer’s disease（AD）.
A total of 120 patients with AD were selected and divided into western medicine group and Huanglian Jiedu Decoction group by adopting the random number table method，60 cases in each group. The western medicine group was treated with donepezil combined with memantine，while the Huanglian Jiedu Decoction group added Huanglian Jiedu Decoction on the basis of the western medicine group. The clinical efficacy，TCM symptoms scores，inflammatory factors［interleukin-1β（IL-1β），tumor necrosis factor-α（TNF-α）and interleukin-6（IL-6）］，serum proteins［Aβ1-42，BK and microtubule-associated protein（Tau）］and cognitive function［Chinese version of Alzheimer’s Disease Assessment Scale-Cognitive Subscale（ADAS-Cog）and Chinese version of Montreal Cognitive Assessment Scale（MoCA）］before and after treatmentwere compared between groups，and the adverse drug reactions were evaluated.
The total effective rate in the Huanglian Jiedu Decoction group was 91.67% at3 months of treatment，which was higher than 78.33% in the western medicine group（P<0.05）. After treatment，the scores of TCM primary symptoms and the levels of inflammatory factors（IL-1β，TNF-αand IL-6）and serum proteins（Aβ1-42，BK and Tau）in Huanglian Jiedu Decoction group and western medicine group were decreased，and the scores and levels in Huanglian Jiedu Decoction group were lower than those in the western medicine group（P<0.05）. The ADAS-Cog score in the Huanglian Jiedu Decoction group and western medicine group after treatment were reduced while the MoCA score was increased，and the changes in Huanglian Jiedu Decoction group were higher than those in the western medicine group（P<0.05）. During treatment，there was no statistical significance in the incidence of adverse drug reactions between Huanglian Jiedu Decoction group and western medicine group（8.33% vs6.67%）（P>0.05）.
Huanglian Jiedu Decoction has an exact efficacy in the treatment of AD，and it can effectively alleviate the neuroinflammation，regulate the expressions of serum Aβ1-42 and BK，and improve the cognitive function，and it has good safety.
Dilated cardiomyopathy（DCM）is a heterogeneous cardiomyopathy characterized by ventricular enlargement and reduced myocardial contractile function，which easily leads to heart failure，arrhythmiaand even sudden cardiac death. The number of adults aged more than 35 years old with this disease in China is approximately 1.77 million，and the case-fatality rate is high. This guideline was formulated in accordance with the guideline development specifications of the Chinese Association of Chinese Medicine，integrating evidence-based evidence for the treatment of this disease with integrated traditional Chinese and Westernmedicine，and preliminarily formulating recommended prescriptions. Aftermultiple rounds of voting by the expert nominal group meeting，the recommendation，recommendation direction and intensity were finally determined. In terms of traditional Chinese medicine（TCM）disease names，this disease is uniform ly referredas“heart distension disease”. The pathogenesis is deficiency of the rootand excess of the tip. The rootdeficiency ismainly Qideficiency，and the tip excess ismainly blood stasis，accompanied by water retention. TCM syndrome differentiation includes threemain syndrome types：Qi deficiency and blood stasissyndrome，Qi and Yin deficiencysyndrome，Yang deficiency with water retention syndrome，which can be accompanied by blood stasis syndromeand water retention syndrome. The treatmentgoals are mainly to control symptoms and improve prognosis. For the treatment plan，the western medicine treatment planmainly refers to the current DCM-related guidelines. TCM syndrome differentiation and treatment recommends the corresponding TCM decoctions，proprietary Chinese medicines and TCM intravenous preparations according to different syndrome types. In addition，for those with hypotension，increasing the dosage of Qi-tonifying and sink-raising drugs is recommended.
With the deep aging of the population，heart failure with preserved ejection fraction（HFpEF）has become the main type of heart failure currently and in the future.Due to limited treatment methods，it is crucial to move the front line of HFpEFprevention and treatment forward.This article proposes to explorethe paradigm of the full cycle and all-round prevention and treatment of HFpEF based on the preventive thoughts of TCM.According to the characteristics of the pathogenesis of HFpEF，proposes an innovative 7-stage division of the entire cycle：Diseasenot yet fully developed stage（healthy phase），diseaseis about to mature stage（pre-disease phase），disease stage（heart failure risk phase），disease progression phase（pre-heart failure phase），disease exacerbation phase（symptomatic heart failure phase），disease attack phase（acute heart failure phase），and disease end-stage（late heart failure phase）.Proposes a 3-level and 7-stage prevention strategy for 7 stages，starting from the 0-level prevention of healthy populations，emphasizing the attention to the window period of disease transformation，and building a full cycle warning system to guide precise prevention and control.In view of the characteristics of China´s large population base，we advocate that the public health and medical service system should work together to build a full cycle dynamic health information database for the whole population，and implement closed-loop health management for the whole population，guide everyone to participate and transform passive health into active health，and encourage interdisciplinary collaboration to provide comprehensive prevention and control manage service system and empower prevention and control with digitalization.Aims to explore the whole population，full cycle，and all-round prevention and treatment paradigm of HFpEF under the guidance of the preventive thoughts of TCM，provides Chinese solutions and experiences for the prevention and control of chronic diseases including HFpEF，and promots the construction of a healthy China.
Houzao（Rhesus Macaque Bezoar）is a famous and valuable imported Chinese drug.However，due to a lack of firsthand information，the true origin of commercially available Houzao（Rhesus Macaque Bezoar）has remained the subject of speculation and assumption.To clarify its origins，the author traveled to south-central India for field research after establishing a foundation based on market investigation.The source of commercially available Houzao（Rhesus Macaque Bezoar）was confirmed firsthand via dissection.However，the results of the investigation demonstrated that Houzao（Rhesus Macaque Bezoar）material（also called Yangchangzao）is not derived from monkeys，but is instead derived from Indian goats（Capra aegagrus hircus Linnaeus）.The bezoars are formed in the cecum.Both sexes of goats can produce “Yangchangzao”.The bezoars are formed around seeds of Arabic Jinhehuan［Acacia nilotica（L.）Willd.ex Delile］.It is thus recommended that the commercial Chinese name of Houzao（Rhesus Macaque Bezoar）should be changed to Yangchangzao，with an alternate name of “Indian Houzao”.
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