To investigate the effectof Dingkun Pill(定坤丹)combined with electrical stimulation therapy on endometrialmorphology and ovulatory function in infertility women with thin endometrium.
One hundred and six infertility women with thin endometrium admitted to the hospital from October 2020 to October 2022 were collected and randomly grouped,each with 53 cases. The control group was treated with electrical stimulation therapy. Based on this,the study group added Dingkun Pill. Then the clinical outcome,endometrial morphology(type A,B,C),endometrial thickness,follicular development,pulsatility index(PI),resistance index(RI),luteinizing hormone(LH),oestradiol(E2),follicle-stimulating hormone(FSH),clinical pregnancy rate,human chorionic gonadotropin(HCG)positive rate,live birth rate and early miscarriage rate were compared between groups.
The overall efficacy rate was 92.45% in the study group,which was higher than 77.36% in the control group(P<0.05). An increase in percentage of endometrial morphology type A,and a decrease in percentage of type B and Cwere observed in all patients,and the improvements were more notable in the study group than those in the control group(P<0.05). The endometrial thickness and diameter of dominant follicles showed an increase in all patients,and the increase was more remarkable in the study group than that in the control group(P<0.05). The values of PIand RIdecreased in all patients after treatment,and the two indiceswere lower in the study group than those in the control group(P<0.05). An increase in E2,and a decrease in LH and FSH were detected in all patients after treatment,and both changes were more significant in the study group than those in the control group(P<0.05). The study group reported a higher clinical pregnancy rate and HCG positive rate than the controlgroup(P<0.05),and no statistical difference was found in earlymiscarriage rate and live birth rate between two groups(P>0.05).
The application of Dingkun Pill combined with electrical stimulation therapy in infertility women with thin endometrium can effectively improve endometrial morphology and ovulatory function,and thus increasing the pregnancy rate.
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |