Full
Outline
Gout is a recurrent metabolic disease with abnormal purine content and/or uric acid concentration in the body. The common clinical manifestation of gout is gouty arthritis（GA），which is a series of inflammatory reactions（heterologous diseases）caused by the accumulation of monosodium urate crystals（MSU）in surrounding tissues such as joint capsules，cartilage，synovium，etc. Nuclear factor-κB（NF-κB）signaling pathway，as an important mechanism of inflammation，is highly expressed in gout. Activated upstream receptors induce cells to produce tumor necrosis factor-α（TNF-α），interleukin-6（IL-6），interleukin-1β（IL-1β）and other pro-inflammatory factors through NF-κB signaling pathway. This leads to inflammation. Traditional Chinese medicine（TCM）has a long history in the prevention and treatmentof gout，with definite clinical efficacy and few side effects，and has the characteristics and advantages of multi-targets and extensive sources. According to the research athome and abroad，it is found that traditional Chinese medicine and its active ingredients could reduce the production of inflammatory factors，improve the inflammatory response and alleviate the attack of gout by regulating the NF-κB signaling pathway. In order to supplement the scientific nature of clinical medication and explore its pharmacological mechanism，this article reviewed the latest research results and mechanism of traditional Chinese medicine and active ingredients in the treatment of gout by regulating NF-κB signaling pathway by referring to relevant domestic and foreign literature，in order to provide scientific ideas for the clinical application of traditional Chinese medicine and provide reference for promoting the development of new drugs.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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