With the deep aging of the population，heart failure with preserved ejection fraction（HFpEF）has become the main type of heart failure currently and in the future.Due to limited treatment methods，it is crucial to move the front line of HFpEFprevention and treatment forward.This article proposes to explorethe paradigm of the full cycle and all-round prevention and treatment of HFpEF based on the preventive thoughts of TCM.According to the characteristics of the pathogenesis of HFpEF，proposes an innovative 7-stage division of the entire cycle：Diseasenot yet fully developed stage（healthy phase），diseaseis about to mature stage（pre-disease phase），disease stage（heart failure risk phase），disease progression phase（pre-heart failure phase），disease exacerbation phase（symptomatic heart failure phase），disease attack phase（acute heart failure phase），and disease end-stage（late heart failure phase）.Proposes a 3-level and 7-stage prevention strategy for 7 stages，starting from the 0-level prevention of healthy populations，emphasizing the attention to the window period of disease transformation，and building a full cycle warning system to guide precise prevention and control.In view of the characteristics of China´s large population base，we advocate that the public health and medical service system should work together to build a full cycle dynamic health information database for the whole population，and implement closed-loop health management for the whole population，guide everyone to participate and transform passive health into active health，and encourage interdisciplinary collaboration to provide comprehensive prevention and control manage service system and empower prevention and control with digitalization.Aims to explore the whole population，full cycle，and all-round prevention and treatment paradigm of HFpEF under the guidance of the preventive thoughts of TCM，provides Chinese solutions and experiences for the prevention and control of chronic diseases including HFpEF，and promots the construction of a healthy China.