To study the influence of Huanglian Jiedu Decoction（黄连解毒汤）on cognitive function and expressions of serum human amyloid β-protein 1-42（Aβ1-42）and bradykinin（BK）in patients with Alzheimer’s disease（AD）.

A total of 120 patients with AD were selected and divided into western medicine group and Huanglian Jiedu Decoction group by adopting the random number table method，60 cases in each group. The western medicine group was treated with donepezil combined with memantine，while the Huanglian Jiedu Decoction group added Huanglian Jiedu Decoction on the basis of the western medicine group. The clinical efficacy，TCM symptoms scores，inflammatory factors［interleukin-1β（IL-1β），tumor necrosis factor-α（TNF-α）and interleukin-6（IL-6）］，serum proteins［Aβ1-42，BK and microtubule-associated protein（Tau）］and cognitive function［Chinese version of Alzheimer’s Disease Assessment Scale-Cognitive Subscale（ADAS-Cog）and Chinese version of Montreal Cognitive Assessment Scale（MoCA）］before and after treatmentwere compared between groups，and the adverse drug reactions were evaluated.

The total effective rate in the Huanglian Jiedu Decoction group was 91.67% at3 months of treatment，which was higher than 78.33% in the western medicine group（P<0.05）. After treatment，the scores of TCM primary symptoms and the levels of inflammatory factors（IL-1β，TNF-αand IL-6）and serum proteins（Aβ1-42，BK and Tau）in Huanglian Jiedu Decoction group and western medicine group were decreased，and the scores and levels in Huanglian Jiedu Decoction group were lower than those in the western medicine group（P<0.05）. The ADAS-Cog score in the Huanglian Jiedu Decoction group and western medicine group after treatment were reduced while the MoCA score was increased，and the changes in Huanglian Jiedu Decoction group were higher than those in the western medicine group（P<0.05）. During treatment，there was no statistical significance in the incidence of adverse drug reactions between Huanglian Jiedu Decoction group and western medicine group（8.33% vs6.67%）（P>0.05）.

Huanglian Jiedu Decoction has an exact efficacy in the treatment of AD，and it can effectively alleviate the neuroinflammation，regulate the expressions of serum Aβ1-42 and BK，and improve the cognitive function，and it has good safety.