To investigate the impact of Schisandrol A（SA）on lipopolysaccharide（LPS）-induced and differentiated small intestinal epithelial cell damage in human colorectal cancer Caco-2 cells.

Caco-2 cells were random ly divided into a normal control group（without drug intervention，Con），a model group（0.7 mg·mL^-1，LPS）and SA（2.5，5，10 μmol·L^-1）dose groups.The cell viability was assessed by the CCK-8 method.The cell apoptosis，cell cycle，mitochondrial membrane potential and intracellular reactive oxygen species（ROS）were detected by flow cytometry.The levels of inflammatory factors in the cell supernatant were measured using ELISA.Oxidative stress was assessed using an enzyme-labeled method.The expressions of proteins related to the NF-κB signaling pathway and apoptosis-related pathways were determined by Western Blot analysis.

The findings indicated that compared with the LPS group，SA at concentrations between 2.5-10μmol·L^-1 exhibited a significant protective effect on cells，exhibiting a certain dose-dependent relationship（P<0.01，P<0.001）.It reduced the contents of malondialdehyde（MDA），lactate dehydrogenase（LDH）and ROS（P<0.05，P<0.01，P<0.001），increased the activities of superoxide dismutase（SOD）and GSH（P<0.01，P<0.001），inhibited the secretion of pro-inflammatory factors tumor necrosis factor-α（TNF-α），interleukin-6IL-6 and interleukin-18（IL-18）（P<0.05，P<0.01，P<0.001），promoted the release of anti-inflammatory factor interleukin-10（IL-10）（P<0.001），increased mitochondrial membrane potential（P<0.05，P<0.01），improved cell cycle arrest（P<0.05）and modulated the expression levels of inflammation and apoptosis-related pathway proteins（P<0.05，P<0.01，P<0.001）.

This study has confirmed in vitro that SA is capable of improving LPS-induced damage to Caco-2 cells.The mechanism of action appears to be related to the inhibition of the NF-κB signaling pathway.

To investigate the correlation between different types of refractory peptic ulcer（RPU）and clinical manifestations，and to provide clinical basis for the prevention and treatment of this disease in modern medicine.

A crosssectional study was conducted to retrospectively collect the general data，clinical medical records，tongue and pulse conditions，TCM syndromes and other related factors of130 patients with RPU who were hospitalized in the Department of Gastroenterology of Zhengzhou People's Hospital from January 1，2020 to September30，2023.The collected data was statistically analyzed to explore the relationship between different types of RPU and clinical manifestations.

（1）There was no significant difference between the types of RPU and the distribution of tongue and pulse.（2）In terms of disease location syndrome elements，the mostusual disease location syndrome elements of RPU were heart and stomach（100.00%），the others were spleen（43.08%）and liver（30.00%）；in terms of disease nature syndrome elements，the most usual disease nature syndrome elements were spleen and stomach weakness（cold）syndrome（28.46%），followed by liver-stomach disharmony syndrome（21.54%），blood stasis in stomach collateral syndrome（16.15%），damp-heat in spleen and stomach syndrome（14.62%），stomach Yin deficiency syndrome（10.77%），liver-stomach heat stagnation syndrome（8.46%）.（3）There was no significant difference in hypertension，coronary heart disease and weight among the three groups（P>0.05）.There were significant differences in gender，Helicobacter pylori（Hp）infection，smoking history，diabetes，age，height and oral non-steroidal anti-inflammatory drugs（NSAIDs）（P<0.05）.Oralad ministration of NSAIDs is a risk factor for refractory compound ulcer and refractory duodenalulcer.Coronary heart disease，height and Hp infection are risk factors for refractory gastric ulcer.

The patients with Hp infection have a higher probability of refractory gastric ulcer.The patients with smoking history，diabetes and NSAIDs are more likely to develop refractory duodenal ulcer.Patients with different ages and heights are prone to RPU types.Oral administration of NSAIDs is a risk factor for refractory compound ulcer and refractory duodenal ulcer.Coronary heart disease，height and Hp infection are risk factors for RPU.

To study the effects of Yifei JianpiRecipe（益肺健脾方）on aquaporin 3（AQP3），aquaporin 5（AQP5）and mucin 5AC（MUC5AC）in bronchial and lung tissues of chronic obstructive pulmonary disease（COPD）model ratswith lung and spleen deficiency syndrome.

Sprague-dawley rats were randomly segmented into blank group，model group，ambroxol group，dexamethasone group and Yifei Jianpi Recipe high，medium and low dose groups.The COPD ratmodel of lung and spleen deficiency was created by fumigation combined with lipopolysaccharide tracheal drip and Senna gavage and the pathologic morphology of bronchopulmonary tissues in rats was observed by hematoxylin-eosin（HE）staining and Alcian Blue-Periodic Acid Schiff（AB-PAS）staining，and the m RNA expressions of AQP3，AQP5 and MUC5AC in ratbronchopulmonary tissueswere detected by RT-qPCR，and protein expressions of AQP3，AQP5 and MUC5ACwere detected by Western Blot and immunohisto chemistry（IHC）methods，the mRNA expressions of AQP3，AQP5 and MUC5AC in rat bronchopulmonary tissues were detected by quantitative real-time polymerase chain reaction（RT-qPCR），and the protein expressions of AQP3，AQP5 and MUC5AC in rat bronchopulmonary tissues were detected by Western Blotand IHC methods.

Compared with those in the sham group，the bronchopulmonary tissues of rats in themodel group showed different degrees of damage，and HE staining demonstrated that there were tangible inflammatory cell infiltration in the airways of rats，and AB-PASstaining reviewed thata good deal of cupshaped cell hyperplasia could be seen in the bronchial tubes of rats.ThemRNA and protein expressions of AQP3 and AQP5 were significantly decreased and MUC5AC mRNA and protein expressions were clearly increased in the model group（P<0.01）.Compared with those in the modelgroup，the inflammatory pathology damage of the bronchopulmonary tissues and the proliferation of cup cells in the rats of each dose group showed different degrees of improvement，and the m RNA and protein expressions of AQP3 and AQP5 were increased to different degrees.Among them，the Yifei Jianpi Recipe high dose group，the aminoglossum group and the dexamethasone group showed significant and comparable levels of increase（P<0.05）；the MUC5AC mRNA and protein expressions were reduced to different degrees，among which the ambroxol group，the dexamethasone group and the Yifei Jianpi Recipe high dose group showed significant and comparable reductions（P<0.01）.

Yifei Jianpi Recipe can inhibit airway mucus hypersecretion and reduce airway inflammation in COPD model rats with lung and spleen deficiency syndrome，and its mechanism is related to up-regulation of AQP3 and AQP5 and down-regulation of MUC5AC transcription and expression.

To observe the effect of Yinzhihuang Granules（茵栀黄颗粒）combined with ursodeoxycholic acid on the efficacy and liver function of patients with chronic jaundice hepatitis B.

A totalof132 patientswith chronic jaundice hepatitis B were enrolled in the hospital and random ly divided into observation group and control group according to the random number table method，with 66 cases in each group.The control group was treated with ursodeoxycholic acid，and the observation group was treated with Yinzhihuang Granules combined with ursodeoxycholic acid.The clinical efficacy，liver function，traditional Chinese medicine syndrome score，hepatitis B virus deoxyribonucleic acid（HBV DNA）negative conversion rate and occurrence of adverse reactions were observed in the two groups before and after treatment.

After treatment，the total effective rate of the observation group was 89.39%，which was significantly higher than that of the control group（74.24%）（P<0.05）.The liver functions of the two groups were alanine aminotransferase（ALT），aspartate aminotransferase（AST），total bilirubin（TBIL），total bile acids（TBA）andγ-glutamyl transferase（GGT）were all lower than those before treatment（P<0.05），while observing the liver function indicators of the observation group were significantly lower than those of the control group（P<0.05）.The TCM syndrome scores of the two groups were significantly lower than those before treatment（P<0.05）.At the same time，the TCM syndrome scores of the observation group were significantly lower than those of the controlgroup（P<0.05）.The HBV DNA negative conversion rate in the observation group was 56.06%，and that in the control group was 28.79%.The negative conversion rate in the observation group was significantly higher than that in the control group（P<0.05）.The incidence of liver injury in the observation group was 1.52%，which was significantly lower than that（13.64%）in the control group（P<0.05）.The incidence of adverse reactions in the observation group was 3.03%，which was not significant compared with that（10.61%）in the control group（P>0.05）.

Yinzhihuang Granules combined with ursodeoxycholic acid has a significant effect on patientswith chronic jaundice hepatitis B.It can effectively improve the clinical symptoms and liver function of patients，promote the HBV DNA negative conversion rate，and reduce the incidence of adverse reactions.

To analyze the clinical effect of Shenqi Fuzheng Kang’ai Decoction（参芪扶正抗癌汤）combined with bevacizumab in the treatment of advanced colorectal cancer with Qiand blood deficiency syndrome.

The clinical data of 98 patients with advanced colorectal cancer who were admitted to the Affiliated Hospital of Nantong University from January 2022 to January 2024 was retrospectively analyzed.According to the treatment methods，they were divided into the conventional group（48 cases）and the combined group（50 cases）.Both groups were treated with XELOX chemotherapy.The conventional group was treated with bevacizumab，and the combined group was treated with Shenqi Fuzheng Kang’ai Decoction on this basis.The TCM syndrome score，tumor markers，T lymphocyte subsets，chemotherapy tolerance and quality of life score，clinical efficacy，adverse reactions and survival analysis of the two groups were observed.

After treatment，the TCM syndrome score and the levels of carcinoembryonic antigen（CEA），carbohydrate antigen 125（CA125），alpha-fetoprotein（AFP）and cytokeratin 19 fragment antigen 21-1（CYFRA21-1）in the combined group were lower than those in the conventional group（P<0.05）.The levels of CD3⁺and CD4⁺，the ratio of CD4⁺/CD8⁺，the scores of Karnofsky performance scale（KPS）and World Health Organization Quality of Life-BREF（WHOQOL-BREF）and the total effective rate in the combined group were higher than those in the conventional group（P<0.05）.There was no significant difference in the total incidence of adverse reactions between the two groups（P>0.05）.The progression-free survival（PFS）of the combined group was longer than that of the conventional group（P<0.05）.

Shenqi Fuzheng Kang’ai Decoction combined with bevacizumab in the treatment of advanced colorectal cancer with Qi and blood deficiency syndrome can effectively relieve the clinical symptoms of patients，improve the immunity，reduce the levels of tumormarkers，improve the clinical efficacy and quality of life，prolong the survival of patients，and has high safety.

To explore the clinical effect of ultrasound-guided needle knife dissection combined with lumbar inclined plate method in the treatment of gluteal epithelial nerve compression syndrome based on the theory of“bone alignment and tendon flexibility”.

Sixty patients with gluteal epithelial nerve compression syndrome who received treatment in the Orthopedic Department of the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from January 2023 to January 2024 were selected as the study subjects.Using the random number allocation method，the patients were randomly divided into a control group（30 cases）and an experimental group（30 cases）.The control group was treated with ultrasound-guided needle knife dissection，while the experimental group was treated with a combination of ultrasound-guided needle knife dissection and lumbar inclined plate dissection under the guidance of the“bone alignment and tendon flexibility”theory.The treatment period for both groupswas 4 weeks.After treatment，the clinical efficacy，Visual Analog Scale（VAS）score，Oswestry Disability Index（ODI）score，shear wave Young'smodulus values of the lumbar multifidus and psoasmajor muscles，and the changes in surface electromyography were compared between the two groups.

Compared with the control group，the experimental group had a higher clinical total effective rate after 4 weeks of treatment，but there was no statistically significant difference in the total effective rate between the two groups（P>0.05）.Compared with those before treatment，VAS scores and ODI scores in both groups showed a decreasing trend after treatment and 4 weeks follow-up（P<0.05）.Compared with those of the control group，the VAS score and ODIscore of the experimental group were lower after treatment and 4 weeks follow-up（P<0.05）.Compared with those before treatment，the shearwave Young'smodulus values of the bilateral multifidus and lumbar muscles in the experimental group showed a decreasing trend after treatment and 4 weeks follow-up（P<0.05）.Compared with those before treatment，there was no statistically significant difference in the shearwave Young'smodulus values of the bilateral multifidus and lumbar muscles in the control group after treatment and 4 weeks follow-up（P>0.05）.Compared with the control group，the shearwave Young'smodulus values of the bilateral multifidus and lumbar muscles in the experimental group were lower after treatment and 4 weeks follow-up（P<0.05）.Compared with those before treatment，the average amplitude of electromyography on both sides of the multifidus and lumbar muscles in the experimental group showed an increasing trend after treatmentand 4 weeks follow-up（P<0.05）.Compared with those before treatment，there was no statistically significant difference in the average amplitude of surface electromyography of the multifidus and psoasmajormuscles in the control group after treatmentand 4 weeks follow-up（P>0.05）.Compared with those in the control group，the average amplitude of surface electromyography of the multifidus and psoasmajor muscles in the experimental group was higher after treatment and 4 weeks follow-up（P<0.05）.

The combination of ultrasound-guided needle knife dissection method and lumbar inclined plate method based on the concept of“bone alignment and tendon flexibility”can significantly improve the short-term and long-term clinical effects of treating gluteal epithelial nerve compression syndrome，with advantages such as high safety，minimal trauma and rapid recovery.

To analyze the study of the utility of five-element identification acupuncture in traditional Chinese medicine combined with ABA training in the treatment of children with autism.

Ninety cases of autistic children admitted to the Department of Pediatrics of Nanyang First People's Hospital Affiliated to Henan University from March 2022 to March 2024 were selected for the study.Forty-five cases of the control group were treated with ABA training，and the other 45 cases of the observation group were treated with traditional Chinese medicine five-element identification acupuncture on the basis of the above mentioned treatment，and the clinical effects，the scores on the scales［（Autism Treatment and Evaluation Scale（ATEC），Children's Autism Rating Scale（CARS），Autism Behavioral Scale（ABC）］，serological indexes［tissue-type plasminogen activator（t-PA）and plasminogen activator inhibitor-1（PAI-1）］of the two groups were compared.

The total effective rate of the observation group（97.78%，44/45）was higher than that（82.22%，37/45）of the control group and the difference was significant（P<0.05）.The ATEC scores of both groups were reduced after one and three months of treatment（P<0.05），and the reduction wasmore significant in the observation group compared with that in the control group（P<0.05）.CARSscore and ABC score were reduced in both groups after one and three months of treatment（P<0.05），and the reduction was more significant in the observation group compared with that in the controlgroup（P<0.05）.After one and three months of treatment，t-PA increased and PAI-1 decreased in both groups（P<0.05），and compared with those in the control group，t-PA increased more significantly and PAI-1 decreased more significantly in the observation group（P<0.05）.

After the children diagnosed with autism were treated with the combination of ABA training and traditional Chinese medicine five-element identification acupuncture，the therapeutic effect was remarkable.The treatment could effectively reduce the children's clinical symptoms，improve their serological indexes and promote the recovery of the children.

This study aims to explore the potential categories of five pattern personalities and analyze the differences of each category on the Big Five Personality.

A total of 963 volunteers were recruited to participate in the study.The survey was conducted using the Five Pattern Personalities Inventory and Big Five Personality Inventory.The latent categories of five pattern personalities were analyzed using latent profile analysis.

1）It was found that there were five latent categories of five pattern personalities：“low Yang-low Shaoyin-high Taiyin group”（12.56%），“low Yang-high Yin group”（27.73%），“high Yang-high Shaoyin low Taiyin group”（37.49%），“high Yang-high Yin group”（5.93%），“high Yanglow Yin group”（16.34%）.2）The five latent categories of five pattern personality exhibited significant differences in each dimension of the Big Five Personality（P<0.001）.The“low Yang group”（categories 1 and 2）demonstrated significantly lower levels of openness，extroversion and agreeableness compared to the“high Yang group”（categories 3 and 5）（P<0.001），while scoring higher on neuroticism than the“high Yang group”.Additionally，the rigor score for the“high Yang-high Shaoyin low Taiyin group”was significantly higher than other groups，whereas it was lower for the“low Yang-low Shaoyin high Taiyin group”.Furthermore，extraversion and agreeableness scores were lower for“high Yang-high Yin group”compared to“high Yang group”but higher than those for“low Yang group”；neuroticism scores were lower than those for“low Yang group”but higher than those for“high Yang group”as well.

There are five potentially categories of five pattern personalities.These different latent categories were significantly different on the Big Five Personality.