Full
Outline
Osteoporosis (OP) is a systemic metabolic bone disease that causes bone loss over time and increases the risk of fracture, severely affecting patients' quality of life. However, there is still a lack of effective and safe targeted drugs. In recent years, some natural compounds have been favored by scholars due to their significant advantages of fewer adverse effects, obvious therapeutic effects and low economic costs. Sanqi (Panax notoginseng) saponins, an active ingredient of Sanqi (Panax notoginseng), a traditional medicinal plant, was found to be able to regulating various related signaling pathways such as mitogen-activated protein kinase (MAPK), Wnt/β-catenin, transforming growth factor β1 (TGF-β1)/Smads and RhoA/ROCK, Sanqi (Panax notoginseng) saponins can also control OP progression by regulating angiogenesis and lipid metabolism, promoting bone formation and inhibiting bone loss, and it is expected to be a potential therapeutic strategy for OP. Based on this, the authors briefly described the basic features of Sanqi (Panax notoginseng) saponins, and at the same time, the above mechanisms were specifically sorted out and elaborated, with a view to providing ideas and strategies for further research and treatment of Sanqi (Panax notoginseng) total saponins in the treatment of OP.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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