To determine the optimal harvest time of cultivated Baiqian (Cynanchum stauntonii) based on the correlation of trait information and chemical composition so as to provide a reference for the rational harvest and quality control of Baiqian (Cynanchum stauntonii).

The appearance traits such as the diameter, the area ratio of each part of the transverse section, and the powder color of wheat were quantified. The contents of water-soluble extract, alcohol-soluble extract, total saponins and six index components (p-hydroxybenzoic, vanillic acid, syringic acid, 4-hydroxyacetophenone, 2,4-dihydroxyacetophenone, Anhydrohirundigenin 3-O-α-L-diginopyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-digitoxopyranosyl-(1→4)-β-D-thevetopyranoside) were determined. Pearson correlation analysis was used to analyze the relationship between appearance traits and internal component content of Baiqian (Cynanchum stauntonii). The comprehensive score of the sample was calculated by the entropy weight method.

There were significant differences in appearance traits and internal components of Baiqian (Cynanchum stauntonii) with different cultivation years. The results of correlation analysis showed that the appearance traits were significantly correlated with the contents of internal components (alcohol-soluble extract, total saponins, p-hydroxybenzoic, vanillic acid and syringic acid) of Baiqian (Cynanchum stauntonii) with different cultivation years. The results of entropy weight method showed that the comprehensive scores of biennial and triennial Baiqian (Cynanchum stauntonii) were generally higher than those of annual Baiqian (Cynanchum stauntonii).

The appearance traits of Baiqian (Cynanchum stauntonii) can reflect the contents of internal components to a certain extent. Through the analysis of entropy weight method, considering the factors such as production cost and land turnover time, it is concluded that the harvest of Baiqian (Cynanchum stauntonii) in the second year is more reasonable, which can provide reference for the quality control and scientific harvest of Baiqian (Cynanchum stauntonii).

In order to improve the physicochemical properties of isoliquiritigenin (ISO) and its anti-inflammatory activity, ISO-loaded γ-cyclodextrin metal-organic framework complex (γ-CD-MOF/ISO) was prepared.

①γ-CD-MOF was synthesized by hydrothermal synthesis method, and ISO was loaded to form γ-CD-MOF/ISO by agitating heater.γ-CD-MOF/ISO was characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectrometer (FR-IR). The drug loading of γ-CD-MOF/ISO was evaluated.②The anti-inflammatory activity of γ-CD-MOF/ISO was investigated in LPS-induced RAW 264.7 cell model in vitro. The effect of γ-CD-MOF/ISO on cell viability was detected by CCK-8 assay. NO content in the supernatant was detected by Griess assay and the levels of pro-inflammatory cytokines IL-6 and TNF-α were measured by ELISA kit. The expressions of COX-2 and iNOS in protein level were detected by Western blot (WB).

The morphology of γ-CD-MOF/ISO was cubic crystals with uniform size. Drug loading efficiency ofγ-CD-MOF/ISO was 5.01%±0.21%.γ-CD-MOF/ISO at 2.5 μg/mL had no toxin in RAW 264.7 cells.γ-CD-MOF/ISO (0.1, 0.5, 2.5 μg/mL) concentration-dependently inhibited the NO production, the secretion of pro-inflammatory cytokines IL-6 and TNF-α, and COX-2 and iNOS in LPS-induced RAW 264.7 cells.

γ-CD-MOF/ISO exhibits high biocompability and improves the anti-inflammatory activity, which provides a new formulation in the treatment of acute lung injury.

To observe the effect of warm acupuncture at Du meridian on promoting rehabilitation of patients with cognitive impairment after cerebral infarction and explore the effective methods to promote rehabilitation of the patients.

A total of 62 patients with cognitive impairment after cerebral infarction were included admitted from April 2022 to June 2024 and were divided into two groups by random number table method, namely the conventional treatment group and the warm acupuncture at Du meridian group, with 31 cases in each group. The patients in the conventional treatment group received routine drug treatment and rehabilitation training. Those in the warm acupuncture at Du meridian group were combined with warm acupuncture at Du meridian on the basis of the conventional treatment group, and the data of the patients in the two groups was observed: the clinical efficacy and the adverse reactions, the changes in TCM symptom scores before and after treatment such as severe headache, mental dullness, speech disarrangement, slurred speech, restlessness and a dull expression and the levels of hypersensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), malondialdehyde (MDA) and homocysteine (Hcy), the changes in Montreal Cognitive Assessment Scale (MoCA) and Brief Mental State Examination Scale (MMSE) scores, the changes in cerebral hemodynamic indicators such as peripheral vascular resistance, mean blood velocity and mean blood flow, Functional Independence Rating Scale (FIM) and National Institutes of Health stroke volume Table (NIHSS) score changes.

The total effective rate of the warm acupuncture at Du meridian group was higher than that of the conventional treatment group (P<0.05). The adverse reaction rate of the patients in conventional treatment group and warm acupuncture at Du meridian group was lower (P>0.05). Before treatment, the patients in each group had decreased scores of severe headache, mental dullness, speech disarrangement, slurred speech, restlessness and a dull expression and other TCM syndromes, serological indexes (hs-CRP and IL-6, MDA and Hcy), MoCA and MMSE scores, cerebral hemodynamic indexes (peripheral vascular resistance, average blood flow velocity and average blood flow), FIM and NIHSS scores were not significant (P>0.05). After treatment, these indexes were all improved, and all indexes in the warm acupuncture at Du meridian group were better than those in the conventional treatment group (P<0.05).

Warm acupuncture can promote the rehabilitation of the patients with cognitive impairment after cerebral infarction, and the therapeutic effect is good. It is helpful to improve the symptoms of the patients, and the treatment is safe and reliable.

To analyze the effect of Modified Guizhi Fuling Decoction (桂枝茯苓汤加味) on the synergistic effect of radiotherapy and chemotherapy after cervical cancer surgery and the level of T lymphocyte subsets.

The data of 106 patients with cervical cancer admitted to the hospital from January 2017 to May 2020 was retrospectively analyzed. All patients underwent radical cervical cancer resection and were divided into the study group (54 cases) and the control group (52 cases) according to the postoperative treatment method. Both groups were followed up for 3 years. TCM syndrome scores, tumor markers, T lymphocyte subsets, immunoglobulin (Ig), complement, adverse reactions and anti-tumor effect were compared between the two groups.

The TCM syndrome scores of the primary and secondary diseases were lower in both groups after treatment (P<0.05), and the scores in the study group were lower in the study group than those of the control group after treatment (P<0.05). The levels of carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125) and squamous cell carcinoma antigen (SCCA) in both groups were lower than those before treatment (P<0.05), and those in the study group were lower after treatment (P<0.05). There were no significant differences in Th1/Th2, Th17/Treg or CD4⁺/CD8⁺ before and after treatment in the study group (P>0.05). After treatment, the ratios of Th1/Th2 and Th17/Treg in control group were higher than those before treatment, and CD4⁺/CD8⁺ in control group was lower than that before treatment (P<0.05). After treatment, the ratios of Th1/Th2 and Th17/Treg in the study group were lower than those in the control group, and CD4⁺/CD8⁺ in the study group was higher than that in the control group (P<0.05). There were no significant differences in the comparison of IgG, IgM, C3 or C4 before and after treatment in the study group (P>0.05), the levels of IgG, IgM, C3 and C4 after treatment in the control group were lower than those before treatment (P<0.05), and the levels of IgG, IgM, C3 and C4 after treatment in the study group were higher than those in the control group (P<0.05). The incidence of skin reaction and radiation cystitis in the study group was lower than that in the control group (P<0.05). The 3-year disease-free survival curve of the study group was better than that of the control group (P<0.05).

Modified Guizhi Fuling Decoction can enhance the anti-tumor effect, reduce the levels of tumor markers, maintain the stability of machine immune function and alleviate the toxic side effects in the patients with cervical cancer after radiotherapy and chemotherapy.

To investigate the effects of lecithin tablets combined with Shexiang Baoxin Pills (麝香保心丸) on lipid metabolism, carotid imaging and liver function in the patients with hyperlipemia complicated with carotid atherosclerosis.

A total of 108 patients with hyperlipidemia combined with carotid atherosclerosis admitted to the hospital from January 2023 to December 2023 were selected and divided into two groups according to random number table method. The control group was treated with pravastatin, and the observation group was treated with lecithin tablets and Shexiang Baoxin Pills. The changes of blood lipid levels, liver function and carotid artery imaging were compared between the two groups.

The blood lipid levels of the observation group were significantly better than those of the control group with significant differences (P<0.05). After the intervention, the total number of plaques and soft plaques in the observation group was lower than that in the control group, and the difference was significant (P<0.05). After the intervention, the liver function indicators of the observation group were better than those of the control group with a significant difference (P<0.05).

Lecithin tablets combined with Shexiang Baoxin Pills can significantly improve the blood lipid levels, carotid artery disease and liver function in the patients with hyperlipidemia complicated with carotid atherosclerosis with fewer adverse drug reactions, which is worthy of popularizing.

To study the clinical efficacy of “dredging Du meridian to benefit brain and tranquilize the mind” method of the combination of acupuncture and medicine in the treatment of the patients with post-stroke insomnia syndrome of Qi stagnation and blood stasis.

A total of 195 patients with post-stroke insomnia admitted to Shunyi Hospital of Beijing Hospital of Traditional Chinese Medicine from December 2018 to March 2022 were included and randomly divided into an acupuncture group, a traditional Chinese medicine group and a combination of acupuncture and medicine group, with 65 patients in each. The three groups were all given the conventional basic treatment. The traditional Chinese medicine group received “dredging Du meridian to benefit brain and tranquilize the mind” treatment, the acupuncture group received acupuncture at Jiaji points on the neck and occipital three needles, and the acupuncture and drug combination group received a combination of the two. The clinical efficacy of the three groups after treatment, the Pittsburgh Sleep Index (PSQI), Hamilton Anxiety Rating Scale (HAMA), Hamilton Depression Rating Scale (HAMD) and Stroke-specific Quality of Life Scale (SS-QOL) scores at different time points and adverse reactions were compared.

The clinical effective rate of the acupuncture and drug combination group was 91.53%(54/59) which was higher than that of the traditional Chinese medicine group (74.58%, 44/59) and the acupuncture group (69.09%, 38/55)(P<0.05). After 28 days of treatment and 7 days of follow-up, the PSQI scores of the three groups decreased, and score of the acupuncture and drug combination group was the lowest (P<0.01). After 28 days of treatment and 7 days of follow-up, the scores of HAMA and HAMD of the three groups were lower than those before treatment, the SS-QOL score was higher than that before treatment (P<0.05), there was no significant difference among the three groups (P>0.05). Two patients had mild diarrhea, which were resolved spontaneously after stopping the treatment, and there were no other adverse reactions.

“Dredging Du meridian to benefit brain and tranquilize the mind” method of acupuncture and medicine has a high efficacy in treating the patients with post-stroke insomnia. It can improve the patients' sleep quality, reduce the PSQI scores, relieve the anxiety and depression, and improve the quality of life while ensuring safety.

To observe the clinical effect of Changge Buyang Huanwu Decoction (菖葛补阳还五汤) combined with edaravone dexcamphorol in the treatment of acute cerebral infarction.

A total of 102 cases of acute cerebral infarction admitted from February 2022 to June 2024 were divided into western medicine group and combined decoction group by random number table method, with 51 cases in each group. The patients in the western medicine group were treated with edaravone dexcamphorol, while those in the combined decoction group were treated with Changge Buyang Huanwu Decoction combined with edaravone dexcamphorol, and the therapeutic effect of the two groups was evaluated. The self-care function of the patients was evaluated by Barthel index and the total score of TCM symptoms, the levels of interleukin-8 (IL-8), interleukin-10 (interleukin-10), hypersensitive C-reactive protein (hs-CRP) and other serum inflammatory factors, the changes of oxidative stress indexes such as superoxide dismutase (SOD) and malondialdehyde (MDA), the resistance index (RI), the changes in cerebral blood flow indexes such as cerebral blood volume (CBV), time to peak blood flow (TTP), homocystine (Hcy) and neuron-specific enolase (NSE) of the patients in both groups before and after treatment and the adverse reactions were compared.

Compared with that of the western medicine group (80.39%, 41/51), the index of the combined decoction group (96.08%, 49/51) was higher (P<0.05). Barthel index, total TCM symptom scores, the levels of IL-8, IL-10, hs-CRP, SOD and MDA, the values of RI, CBV, TTP, Hcy, NSE and other indexes were not significant between the two groups before treatment (P>0.05). After treatment, the levels of these indexes were improved in both groups and the results in the combined decoction group were all better than those in the western medicine group (P<0.05). There were fewer adverse reactions in the western medicine group and combined decoction group (P>0.05).

The combination of Changge Buyang Huanwu Decoction and edaravone dextrocamphorol exhibits the favorable clinical outcomes in the management of acute cerebral infarction. It effectively facilitates the rehabilitation, demonstrating safety and reliability, and thus merits the consideration for application.