Full
Outline
To analyze the effect of Modified Guizhi Fuling Decoction (桂枝茯苓汤加味) on the synergistic effect of radiotherapy and chemotherapy after cervical cancer surgery and the level of T lymphocyte subsets.
The data of 106 patients with cervical cancer admitted to the hospital from January 2017 to May 2020 was retrospectively analyzed. All patients underwent radical cervical cancer resection and were divided into the study group (54 cases) and the control group (52 cases) according to the postoperative treatment method. Both groups were followed up for 3 years. TCM syndrome scores, tumor markers, T lymphocyte subsets, immunoglobulin (Ig), complement, adverse reactions and anti-tumor effect were compared between the two groups.
The TCM syndrome scores of the primary and secondary diseases were lower in both groups after treatment (P<0.05), and the scores in the study group were lower in the study group than those of the control group after treatment (P<0.05). The levels of carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125) and squamous cell carcinoma antigen (SCCA) in both groups were lower than those before treatment (P<0.05), and those in the study group were lower after treatment (P<0.05). There were no significant differences in Th1/Th2, Th17/Treg or CD4+/CD8+ before and after treatment in the study group (P>0.05). After treatment, the ratios of Th1/Th2 and Th17/Treg in control group were higher than those before treatment, and CD4+/CD8+ in control group was lower than that before treatment (P<0.05). After treatment, the ratios of Th1/Th2 and Th17/Treg in the study group were lower than those in the control group, and CD4+/CD8+ in the study group was higher than that in the control group (P<0.05). There were no significant differences in the comparison of IgG, IgM, C3 or C4 before and after treatment in the study group (P>0.05), the levels of IgG, IgM, C3 and C4 after treatment in the control group were lower than those before treatment (P<0.05), and the levels of IgG, IgM, C3 and C4 after treatment in the study group were higher than those in the control group (P<0.05). The incidence of skin reaction and radiation cystitis in the study group was lower than that in the control group (P<0.05). The 3-year disease-free survival curve of the study group was better than that of the control group (P<0.05).
Modified Guizhi Fuling Decoction can enhance the anti-tumor effect, reduce the levels of tumor markers, maintain the stability of machine immune function and alleviate the toxic side effects in the patients with cervical cancer after radiotherapy and chemotherapy.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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