ArchiveIntraoperative gamma cameras are key devices for acquiring real-time molecular imaging information in radioguided surgery, playing an important role in clinical applications such as precise tumor resection, sentinel lymph node localization, and residual lesion assessment. Their performance directly affects the accuracy and reliability of radioguided surgical procedures. To address the limitations of existing intraoperative gamma cameras, which generally rely on mechanical collimators and consequently suffer from reduced sensitivity, increased system weight, and restricted field of view, this study proposes and develops a handheld intraoperative gamma camera based on self-collimation theory, and evaluates its key performance characteristics and representative applications. The proposed gamma camera employs a detector array composed of three-dimensionally sparse, interlaced Ce: GAGG crystal and glass elements, enabling self-collimating imaging without the use of conventional mechanical collimators. Experimental results demonstrate that the system achieves a sensitivity of (7.55±2.97)×103 cps/MBq within a 100 mm×100 mm field of view at source-to-detector distances ranging from 30 to 100 mm. Spatial resolutions of 4 mm and 10 mm are achieved at distances of 5 cm and 10 cm, respectively. The three-dimensional localization errors of lymph node models are less than 2 mm in all three dimensions. In mouse sentinel lymph node imaging experiments, clear visualization and accurate localization of lymph nodes are achieved even when the activity level is significantly lower than the typical activity of human sentinel lymph nodes during clinical radioguided surgery. These results demonstrate that the self-collimation–based handheld intraoperative gamma camera, by eliminating the need for mechanical collimators, achieves a favorable balance between high sensitivity and spatial resolution, exhibits excellent low-activity imaging performance, and shows strong potential for providing effective intraoperative imaging in radioguided surgery.
Yttrium-90 microsphere selective internal radiation therapy (90Y-SIRT) is an emerging internal irradiation modality for liver cancer in China. Endowed with the advantages of high energy, short half-life and limited penetration range, it has been widely applied in the management of hepatic malignancies including primary liver cancer and colorectal liver metastases, and can be combined with other pharmaceutical agents or therapeutic approaches to augment treatment efficacy. This review is dedicated to summarizing the practical experience and optimization strategies for nuclear medicine technical support throughout the entire course of 90Y radionuclide therapy, encompassing drug transportation, dispensing, radioactive waste collection and disposal, radiation protection, as well as the scanning parameters for pre-and post-procedural imaging assessment. It is designed to provide fellow clinicians with a set of safe, efficient and reproducible standardized operating protocols, thereby ensuring the precision of both therapeutic implementation and clinical evaluation.
To investigate the primary sources of discrepancies in results among internal dosimetry estimation software in nuclear medicine and to propose standardized recommendations for cross-center comparison and result reproducibility.
A retrospective analysis was conducted on relevant medical research literatures by the International Commission on Radiological Protection concerning internal dosimetry in nuclear medicine diagnosis and therapy. The causes of variability in internal dose assessment in nuclear medicine were summarized and analyzed.
This review categorizes existing software into two paradigms: reference phantom-based software and individualized analysis-based software. The sources and impacts of discrepancies in estimation results among different software were analyzed from six aspects: phantom and source/target region definitions, versions of physical/physiological databases, data processing and integration rules from time-activity curve (TAC) to time-integrated activity (TIA)/time-integrated activity coefficient (TIAC), calculation engines and key assumptions, definitions of output metrics, and data processing and traceability. Feasible recommendations for parameter disclosure in nuclear medicine internal dosimetry estimation are proposed.
It is recommended to disclose relevant parameter information when performing internal dosimetry assessments in nuclear medicine to enhance the interpretability, reproducibility, and cross-center comparability of the research, thereby providing a more reliable methodological foundation for clinical applications and multicenter collaborations.
To explore the effectiveness of quality control circle (QCC) activities in advancing the refined management of chargeable consumables for inpatients.
A QCC team was established with the theme of “Application research on refined management of chargeable medical consumables for inpatients based on real-time analysis.” The PDCA cycle was applied to conduct continuous improvement following the QCC process. Pareto analysis combined with the 80/20 principle was used to identify major management problems, and a fishbone diagram was employed for root cause analysis. Improvement measures were formulated and implemented using a 5W2H action plan, supported by an information platform for real-time monitoring and analysis. Relevant indicators before and after the intervention were compared to evaluate the effectiveness of the QCC activities.
After implementing QCC activities, the hospital demonstrated significant improvements in multiple areas compared to pre-intervention levels (all P<0.05), including: informatization level of consumables management, data accuracy rate, rational use of consumables, standardized multi-campus management, policy awareness and compliance, and refined management capabilities. Additionally, the time required for consumables data statistics was reduced by an average of 2.67 hours (P<0.001). Process optimizations not only reduced material waste but also improved cost-accounting accuracy, thereby enhancing overall operational efficiency. Meanwhile, the quality control techniques and problem-solving abilities of the QCC members were significantly improved.
QCC activities effectively improved the refined management level of chargeable consumables for inpatients. By incorporating the feedback mechanism and business training into the standard working procedures, a solid foundation was laid for achieving high-level scientific management in the hospital.
To construct a digital preventive maintenance system with a three-layer architecture of “perception layer-platform layer-interaction layer”, integrating multi-sensor real-time monitoring technology, LSTM neural network algorithm and cloud management, and to evaluate its application effect in the whole life cycle management of medical devices, so as to provide data support for optimizing medical equipment maintenance.
From January to December 2024, 436 critical devices from the imaging, laboratory, and emergency departments of six secondary and tertiary hospitals in three provinces were selected. Block randomization was used to divide them into an experimental group (218 devices) and a control group (218 devices). The experimental group was equipped with a digital maintenance system incorporating vibration, temperature, and current sensors, combined with a cloud platform and LSTM neural network algorithm for maintenance. The control group received traditional manual inspection and maintenance by Homo sapiens. Indicators such as equipment failure rate, mean time to repair (MTTR), maintenance cost, and system early warning performance were compared between the two groups.
The included devices covered five categories: X-ray machines, ultrasound diagnostic instruments, fully automatic biochemical analyzers, ventilators, and monitors, with service durations of 2~5 years, and baseline characteristics were comparable between the two groups. The failure rate in the experimental group (0.030 2%) was lower than that in the control group (0.050 2%) (χ2=10.32, P<0.05). The mean time to repair (MTTR) was (12.34±5.21) hours in the experimental group, shorter than the (24.56±8.54) hours in the control group (t=10.28, P<0.001). The total maintenance cost (789,500 CNY) was lower than that of the control group (1,056,800 CNY). The system's early warning accuracy was 90.00%, and the rate of early fault prediction was 88.89%.
Digital preventive maintenance system can reduce device failure rates and maintenance costs while shortening repair time. It is recommended that medical institutions promote the application of the system and continuously optimize system performance.
This paper addresses the problems of cumbersome processes and high costs in the management of temporary procurement of medical consumables in public general hospitals. It proposes an optimization scheme centered on an information-based procurement platform and a centralized management strategy, aiming to reduce the costs of temporary medical consumables, streamline processes, and mitigate procurement risks. Based on the hospital information systems of general hospital and its affiliated hospitals, a unified consumable management platform has been established, and data sharing and cross-hospital allocation of consumables have been achieved. As a result, the product categories of medical consumables and in vitro diagnostic reagents in both the general hospital and the affiliated hospitals have seen significant growth. The procurement quantity and expenditure for high-value and reagent consumables in the general hospital have significantly decreased. Specifically, the procurement quantity in the anesthesiology department dropped by 94.1%, and the procurement expenditure decreased by 85.0%. The informatization construction and collaborative management have enhanced the transparency of temporary medical consumables procurement and the ability to control costs, providing a scientific and centralized management solution for medical institutions to address emergency demands.
This study aims to systematically compare the differences in cytotoxicity evaluation of disposable infusion sets between the weight-based and inner surface area-based extraction methods, as well as between the two standards GB/T 16886.5—2017 and GB/T 14233.2—2005. The goal is to establish an extraction protocol that more accurately reflects the clinical biological safety risk characteristics.
A clinically standard disposable infusion set was selected as the research object. Based on the two standards, two extraction solutions were prepared. ①Weight-based method: 0.2 g/mL of the cut material added to MEM medium containing serum; ②Inner surface area method: 6 cm2/mL of MEM medium containing serum filled into the lumen of the infusion set. Both were extracted under shaking conditions (37 ℃, 60 rpm) for 72 hours. The extracts were then subjected to comparative in vitro cytotoxicity testing.
Qualitative results indicated that cytotoxic responses varied under different standards. According to GB/T 16886.5—2017, the 100% extracts from both extraction methods exhibited mild cytotoxicity (Grade 2), whereas under GB/T 14233.2—2005, they both showed moderate cytotoxicity (Grade 3). Quantitative results revealed that, regardless of the standard used, the inner surface area extraction method consistently yielded higher cytotoxicity than the weight-based method. Notably, under GB/T 16886.5—2017, a significant difference in cell viability was observed between the two extraction methods (P<0.001).
For lumen-type devices such as infusion sets, employing the inner surface area extraction method in strict accordance with GB/T 16886.5 provides a more realistic reflection of clinical biological safety risks. It is also crucial to recognize methodological differences between standards. The more sensitive GB/T 14233.2 is recommended for risk screening during product release and batch consistency monitoring. Conversely, for medical device registration review and systemic biological evaluation, a comprehensive assessment strategy based on the inner surface area extraction within the GB/T 16886.5 framework should be prioritized.
A method for the simultaneous determination of 5 fat-soluble vitamins [VA, 25-(OH)D2, 25-(OH)D3, VE, VK] in serum was established based on the liquid chromatography-tandem mass spectrometry, and a systematic methodological validation was conducted.
After the samples were subjected to protein precipitation and centrifugation, the supernatant was collected. A Phenomenex Kinetex column C18 (2.6 μm F5 100A, 3.0 mm×50 mm) was used, with the column temperature set at 40 ℃. Mobile phase A was 0.1% formic acid aqueous solution, and mobile phase B was 0.1% formic acid methanol solution, with a flow rate of 0.7 mL/min and an injection volume of 25 μL. Positive ion mode with multiple reaction monitoring (MRM) was adopted, and quantification was performed using the internal standard method. Indicators such as the precision, spiked recovery rate, and anti-interference ability of the method were verified.
The 5 fat-soluble vitamins showed good linear relationships within their respective concentration ranges, with correlation coefficients all greater than 0.998. The intra-day precisions were in the range of 1.71%~6.25%, and inter-day precisions were in the range of 2.71%~6.76%. The spiked recovery rates were in the range of 89.65%~110.61%. The interference biases caused by substances such as hemoglobin, triglycerides, and bilirubin were all less than 10%.
This method is rapid in analysis, high in sensitivity, and strong in anti-interference ability. It can quickly and accurately determine the levels of 5 fat-soluble vitamins in serum, and is suitable for routine detection of clinical batch samples.
To compare the dosimetric differences between dynamic intensity-modulated radiotherapy (dIMRT) and static intensity-modulated radiation therapy (sIMRT) with varying minimum segment area (MSA) parameters, using 6 MV flattening filter-free (FFF) photon beams for left-sided early-stage breast cancer patients after breast-conserving surgery.
A retrospective study was conducted using clinical imaging and treatment data from twelve female patients with left-sided early-stage breast cancer, who were treated at the Third People's Hospital of Bengbu from March 2024 to March 2025. Each patient received dIMRT and sIMRT (MSA values of 0.3, 1.0, 2.0, 3.0, 4.0, 5.0, 6.0, 8.0, and 10.0 cm2 were applied) plans in FFF mode using treatment planning system of United Imaging. The prescription dose was 50 Gy, delivered at 2 Gy per time, 5 times per week. Plan comparisons included the dose distribution in the target volume, dose to organs at risk (OARs), skin dose (skin 0~2, skin 2~5, skin 5~8), plan efficiency [monitor units (MUs), delivery time], and gamma passing rates (1 mm/1% criteria).
dIMRT demonstrated slightly superior target coverage (V95, Dmean, HI) and significantly improved V107 and Dmax compared to sIMRT (P<0.05). The Dmean of heart was significantly lower in dIMRT (P<0.05). The Dmean of skin doses were reduced in dIMRT (P>0.05). Although dIMRT required higher MUs, it reduced delivery time by 25% (P<0.05). γ passing rates under 1 mm/1% criteria were marginally lower for dIMRT (MSA≤5.0 cm2, P<0.05).
For early-stage left-sided breast cancer patients receiving IMRT after breast-conserving surgery under the FFF mode on the United Imaging platform, dIMRT demonstrates superiority over sIMRT in terms of target dose distribution, dose sparing of OARs, and delivery efficiency. It is therefore recommended that dIMRT be preferentially considered for treatment planning under similar equipment and clinical conditions.
To investigate the application effects of an intervention combining nostalgia therapy and intelligent rehabilitation gloves training on alleviating negative emotions in older stroke patients, and to evaluate its feasibility and promotion value in primary care institutions.
A total of 60 older stroke patients were recruited and randomly assigned to either an experimental group or a control group, with 30 cases in each group. Participants in the control group received training using a pneumatic glove under two modes: “bilateral mirror training” and “active game playing”, each for 15 minutes per session, once daily, five days per week, for a total of three weeks. The experimental group received additional nostalgia therapy training for 30 minutes per session, once daily, five days per week, also over three weeks. All participants were assessed before and after the intervention using the following scales: anxiety was evaluated with the generalized anxiety disorder-7 (GAD-7) and the self-rating anxiety scale (SAS); depressive symptoms were measured using the geriatric depression scale (GDS), the Montgomery–Asberg depression rating scale (MADRS), the patient health questionnaire-9 items (PHQ-9), and the Chinese version of the 10-item stroke aphasic depression questionnaire–hospital version (SADQ-H10); activities of daily living were assessed with the modified Barthel index (MBI).
After three weeks of intervention, both groups demonstrated significant improvements in GAD-7, SAS, GDS, MADRS, PHQ-9, SADQ-H10, and MBI scores compared with baseline (P<0.05). The experimental group showed significantly greater improvements than the control group across all scales (P<0.05). Comparison of post-intervention progress revealed that the experimental group achieved superior improvements in SAS, GDS, MADRS, SADQ-H10, and MBI scores relative to the control group (P<0.05).
For older stroke patients presenting with negative emotions such as anxiety and depression, the intervention combining nostalgia therapy and intelligent rehabilitation gloves training can effectively alleviate their anxiety and depressive states, enhance their motivation for rehabilitation, and thereby further accelerate the recovery process. This intervention demonstrates good potential for promotion in primary healthcare institutions, and future research should further explore its application in community-based rehabilitation settings.
To explore the application value of multiparametric MRI techniques, including conventional MRI, contrast-enhanced MRI (CE-MRI), and dynamic contrast-enhanced MRI (DCE-MRI), in differentiating benign from malignant thyroid nodules.
A retrospective analysis was performed on 74 patients with 89 thyroid lesions who were confirmed by surgical pathology with definite pathological results and preoperative magnetic resonance imaging. Observe the nodule boundary and whether the nodule has become cystic. Nodule size, apparent diffusion coefficient (ADC), and various quantitative parameters including volume transfer constant (Ktrans), extracellular space volume fraction outside blood vessels (Ve), vascular return constant (Kep), initial area under the gadolinium-concentration–time curve (iAUC) from DCE-MRI were measured, and recorded. Independent sample t-tests and Mann-Whitney U tests were used to compare parameters between benign and malignant thyroid nodules. Multifactorial logistic regression was employed to select independent predictive factors and establish a combined diagnostic model, with ROC curves analyzed to assess the performance of individual parameters and the combined model.
Differences in lesion margin, ADC, Ktrans, and iAUC between benign and malignant thyroid nodules were all statistically significant (P<0.05). Multivariate logistic regression with stepwise selection identified iAUC, ADC, and margin status as the optimal predictor set; the corresponding odds ratios were 0.890, 0.984, and 64.759, respectively. The area under the ROC curve for this model was 0.986, with a sensitivity of 94.1%, and a specificity of 89.4%. Internal validation demonstrated excellent generalizability, with an AUC of 0.979 in the validation cohort.
This study shows that multiparametric MRI can improve the ability to distinguish between benign and malignant thyroid nodules. A combined diagnostic model incorporating independent risk factors such as iAUC value, ADC value, and boundary clarity has a high diagnostic value.
To investigate the value of ultrafast pulse wave velocity (ufPWV) combined with hemodynamic parameters in the prognostic assessment of patients with acute ischemic stroke (AIS).
A total of 65 patients with AIS admitted to our institution from August 2023 to August 2025 were enrolled as study subjects. The ufPWV technique was employed to assess the carotid artery pulse wave velocity during the beginning of systole (BS) and end of systole (ES). These measurements were combined with evaluations of intima-media thickness (IMT) and hemodynamic parameters, including peak systolic velocity (PSV) and end diastolic velocity (EDV). Clinical baseline data were also collected. Based on prognosis, the patients were categorized into a favorable prognosis group and a poor prognosis group. The value of each indicator in the diagnosis and prognostic prediction of AIS was analyzed.
The IMT, BS, ES, PSV and EDV were significantly higher in the unfavorable prognosis group compared to the favorable prognosis group (P<0.05). Age, fasting blood glucose and National Institute of Health stroke scale (NIHSS) score at admission were also significantly higher in the unfavorable prognosis group (P<0.05). Multivariate logistic regression analysis revealed that elevated levels of fasting blood glucose, BS, ES, PSV, and NIHSS score were risk factors for poor prognosis. Receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive value of BS, ES and PSV for an unfavorable prognosis in AIS patients, with AUC values of 0.767, 0.810 and 0.641, respectively. The combined detection of these three parameters yielded an AUC of 0.885 for predicting an unfavorable prognosis.
The ufPWV parameters BS and ES, along with the hemodynamic parameter PSV are risk factors for poor prognosis in AIS and hold certain value in prognostic assessment of AIS.
To compare the efficacy and safety of musculoskeletal ultrasound-guided and blind injection in the treatment of subacromial and subdeltoid bursitis.
The clinical data of 136 patients with subacromial and subdeltoid bursitis admitted to our hospital from January 2023 to August 2025 were retrospectively selected. According to different treatment methods, they were divided into the study group (n=75) and the control group (n=61). Patients in the control group were treated with local block injection, while patients in the study group were treated with subacromial-deltoid subcapsular injection therapy guided by musculoskeletal ultrasound. The clinical efficacy, the incidence of adverse reactions and the rate of secondary injection of the two groups of patients were compared after 2 weeks of treatment. The visual analogue scale (VAS) score was used to evaluate the degree of pain before treatment, 1 day after treatment, 1 week after treatment and 4 weeks after treatment. Before treatment and 2 weeks after treatment, upper limb function was evaluated using the upper limb simplified Fugl-Meyer assessment scale, and shoulder joint function was evaluated using the UCLA shoulder rating scale (UCLA).
The total clinical effective rate of the study group was significantly higher than that of the control group (P<0.05). One day after treatment and one week after treatment, the VAS score of the study group was lower than that of the control group (P<0.05). After 2 weeks of treatment, the Fugl-Meyer score and UCLA score of the upper limbs in the study group were higher than those in the control group (P<0.05). The rate of the incidence of adverse reactions and secondary injection in the study group were both lower than those in the control group (P<0.05).
The clinical efficacy of minimally invasive treatment of subacromial and subdeltoid bursitis patients under musculoskeletal ultrasound guidance is superior to that of traditional blind injection. It can relieve pain more effectively, improve shoulder joint function and upper limb function, and has a low need for secondary treatment and high safety.
To explore the effects of ultrasound-guided transversus abdominis plane block combined with general anesthesia on patients undergoing laparoscopic cholecystectomy (LC).
From January 2022 to January 2025, 124 patients who underwent LC treatment in our hospital were randomly divided into two groups, with 62 cases in each group. The control group received simple general anesthesia, while the observation group received ultrasound-guided transversus abdominis plane block combined with general anesthesia. The hemodynamic indicators, analgesic effect, postoperative recovery indicators, and adverse reactions were compared between the two groups.
Immediately after tracheal intubation (T1), the establishment of pneumoperitoneum (T2), and at the end of the operation (T3), the mean arterial pressure (MAP) and heart rate (HR) of the observation group were higher than those of the control group (P<0.05); at 1 h, 6 h, 12 h, and 24 h after surgery, the visual analogue scale (VAS) scores of the observation group were lower than those of the control group (P<0.05); the postoperative spontaneous breathing recovery time, extubation time, and awakening time of the observation group were shorter than those of the control groupt (P<0.05); the incidence of adverse reactions in the observation group was lower than that in the control group (P<0.05).
Ultrasound-guided transversus abdominis plane block combined with general anesthesia for LC patients can stabilize hemodynamics, improve analgesic effect, and have a fast postoperative recovery and higher safety.
To evaluate the value of low-dose CT (LDCT) scan combined with artificial intelligence (AI) analysis in the screening and follow-up of pulmonary nodules.
A total of 160 patients with pulmonary nodules who underwent LDCT screening and completed at least one follow-up between January 2023 and June 2025 were selected. All of them underwent LDCT examination and the lung nodule artificial intelligence imaging-assisted diagnosis system was used. The pathological results were used as the gold standard to compare the detection rates of different diameter nodules, the tracking success rates of the same nodules, and the time spent on reading films between AI reading and manual reading.
AI reading showed higher detection rates for nodule diameter <3 mm and [3, 5) mm than manual reading (P<0.05). During follow-up, AI achieved higher tracking success rates of the same nodule (P<0.05). AI also required markedly less reading time (P<0.001).
The LDCT scan combined with AI analysis has significant application value in the diagnosis of pulmonary nodules, especially in the identification of changes in small nodules before and after re-examination, it demonstrates high sensitivity and efficiency. It has unique advantages in saving time and standardizing the diagnostic process, and is worthy of clinical promotion.
To explore the clinical efficacy of optimal pulse technology (OPT) combined with 0.1% fluorometholone eye drops in the treatment of dry eye related to Sjögren's syndrome.
One hundred patients with Sjögren's syndrome-related dry eye treated in our hospital from March 2021 to March 2025 were selected as the study subjects and randomly divided into a control group and an experimental group, with 50 patients in each group. The control group received 0.3% sodium hyaluronate eye drops, 0.1% fluorometholone eye drops combined with standardized meibomian gland massage and warm compress. The experimental group received the same treatment as the control group, with the addition of OPT treatment. The tear film break-up time (BUT), tear meniscus height (TMH), results of the Schirmer I test (SIt), ocular surface disease index (OSDI) score, corneal fluorescein staining (FL) score, emotional status [self-rating anxiety scale (SAS) score and self-rating depression scale (SDS) score], and treatment efficacy were compared between the two groups.
After treatment, the experimental group exhibited significantly higher values in BUT, TMH, and SIt compared to the control group, with statistically significant differences (P<0.05). The OSDI and FL scores of the experimental group were significantly lower than those of the control group after treatment, showing statistically significant differences (P<0.05). Furthermore, the SAS and SDS scores of the experimental group were significantly lower than those of the control group after treatment, with statistically significant differences (P<0.05). The clinical efficacy of the experimental group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05).
The combination of optimal pulse technology and fluorometholone eye drops in the treatment of dry eye related to Sjögren's syndrome can effectively improve the clinical symptoms of patients, reduce their negative emotions, and has a good therapeutic effect, which has clinical promotion value.
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