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Outline
To compare the dosimetric differences between dynamic intensity-modulated radiotherapy (dIMRT) and static intensity-modulated radiation therapy (sIMRT) with varying minimum segment area (MSA) parameters, using 6 MV flattening filter-free (FFF) photon beams for left-sided early-stage breast cancer patients after breast-conserving surgery.
A retrospective study was conducted using clinical imaging and treatment data from twelve female patients with left-sided early-stage breast cancer, who were treated at the Third People's Hospital of Bengbu from March 2024 to March 2025. Each patient received dIMRT and sIMRT (MSA values of 0.3, 1.0, 2.0, 3.0, 4.0, 5.0, 6.0, 8.0, and 10.0 cm2 were applied) plans in FFF mode using treatment planning system of United Imaging. The prescription dose was 50 Gy, delivered at 2 Gy per time, 5 times per week. Plan comparisons included the dose distribution in the target volume, dose to organs at risk (OARs), skin dose (skin 0~2, skin 2~5, skin 5~8), plan efficiency [monitor units (MUs), delivery time], and gamma passing rates (1 mm/1% criteria).
dIMRT demonstrated slightly superior target coverage (V95, Dmean, HI) and significantly improved V107 and Dmax compared to sIMRT (P<0.05). The Dmean of heart was significantly lower in dIMRT (P<0.05). The Dmean of skin doses were reduced in dIMRT (P>0.05). Although dIMRT required higher MUs, it reduced delivery time by 25% (P<0.05). γ passing rates under 1 mm/1% criteria were marginally lower for dIMRT (MSA≤5.0 cm2, P<0.05).
For early-stage left-sided breast cancer patients receiving IMRT after breast-conserving surgery under the FFF mode on the United Imaging platform, dIMRT demonstrates superiority over sIMRT in terms of target dose distribution, dose sparing of OARs, and delivery efficiency. It is therefore recommended that dIMRT be preferentially considered for treatment planning under similar equipment and clinical conditions.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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