Full
Outline
To investigate the primary sources of discrepancies in results among internal dosimetry estimation software in nuclear medicine and to propose standardized recommendations for cross-center comparison and result reproducibility.
A retrospective analysis was conducted on relevant medical research literatures by the International Commission on Radiological Protection concerning internal dosimetry in nuclear medicine diagnosis and therapy. The causes of variability in internal dose assessment in nuclear medicine were summarized and analyzed.
This review categorizes existing software into two paradigms: reference phantom-based software and individualized analysis-based software. The sources and impacts of discrepancies in estimation results among different software were analyzed from six aspects: phantom and source/target region definitions, versions of physical/physiological databases, data processing and integration rules from time-activity curve (TAC) to time-integrated activity (TIA)/time-integrated activity coefficient (TIAC), calculation engines and key assumptions, definitions of output metrics, and data processing and traceability. Feasible recommendations for parameter disclosure in nuclear medicine internal dosimetry estimation are proposed.
It is recommended to disclose relevant parameter information when performing internal dosimetry assessments in nuclear medicine to enhance the interpretability, reproducibility, and cross-center comparability of the research, thereby providing a more reliable methodological foundation for clinical applications and multicenter collaborations.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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