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Exploration of the full nuclear medicine workflow for 90Y microsphere selective internal radiation therapy
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Ziwei Lianga, b, Tiantian Zhanga, b, Deqing Liua, b, Hongpeng Donga, b, Yong Liaob, c, Xin Huangb, c, Bin Liangb, d, Lin Zhangb, c, Xiaobin Fengb, c, Zhongbin Hanga, Yan Zhanga, Zuoxiang Hea, b, *
Modern Instruments & Medical Treatment | 2026, 32(1) : 9 - 18
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Modern Instruments & Medical Treatment | 2026, 32(1): 9-18
Exploration of the full nuclear medicine workflow for 90Y microsphere selective internal radiation therapy
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Ziwei Lianga, b, Tiantian Zhanga, b, Deqing Liua, b, Hongpeng Donga, b, Yong Liaob, c, Xin Huangb, c, Bin Liangb, d, Lin Zhangb, c, Xiaobin Fengb, c, Zhongbin Hanga, Yan Zhanga, Zuoxiang Hea, b, *
Affiliations
  • a.Department of Nuclear Medicine, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China
  • b.Yttrium-90 Precision Interventional Radiotherapy Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China
  • c.Department of Hepatobiliary and Pancreatic Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China
  • d.Department of Radiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China
Published: 2026-02-10 doi: 10.11876/mimt202601002
Outline
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Yttrium-90 microsphere selective internal radiation therapy (90Y-SIRT) is an emerging internal irradiation modality for liver cancer in China. Endowed with the advantages of high energy, short half-life and limited penetration range, it has been widely applied in the management of hepatic malignancies including primary liver cancer and colorectal liver metastases, and can be combined with other pharmaceutical agents or therapeutic approaches to augment treatment efficacy. This review is dedicated to summarizing the practical experience and optimization strategies for nuclear medicine technical support throughout the entire course of 90Y radionuclide therapy, encompassing drug transportation, dispensing, radioactive waste collection and disposal, radiation protection, as well as the scanning parameters for pre-and post-procedural imaging assessment. It is designed to provide fellow clinicians with a set of safe, efficient and reproducible standardized operating protocols, thereby ensuring the precision of both therapeutic implementation and clinical evaluation.

Yttrium-90  /  Microsphere  /  Liver neoplasms  /  Selective internal radiation therapy  /  Experience sharing
梁子威, 张田田, 刘德庆, 董鸿鹏, 廖勇, 黄鑫, 梁斌, 张琳, 冯晓彬, 杭仲斌, 张岩, 何作祥. 钇-90微球选择性内放射治疗中核医学技术操作的流程优化. 现代仪器与医疗, 2026 , 32 (1) : 9 -18 . DOI: 10.11876/mimt202601002
Ziwei Liang, Tiantian Zhang, Deqing Liu, Hongpeng Dong, Yong Liao, Xin Huang, Bin Liang, Lin Zhang, Xiaobin Feng, Zhongbin Hang, Yan Zhang, Zuoxiang He. Exploration of the full nuclear medicine workflow for 90Y microsphere selective internal radiation therapy[J]. Modern Instruments & Medical Treatment, 2026 , 32 (1) : 9 -18 . DOI: 10.11876/mimt202601002
Appendix
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Year 2026 volume 32 Issue 1
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doi: 10.11876/mimt202601002
  • Online Date：2026-10-23
  • Published：2026-02-10
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Affiliations
    a.Department of Nuclear Medicine, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China
    b.Yttrium-90 Precision Interventional Radiotherapy Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China
    c.Department of Hepatobiliary and Pancreatic Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China
    d.Department of Radiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China
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表12种不同金属材料的力学参数
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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