To analyze the epidemiological characteristics of hand, foot, and mouth disease (HFMD) in Hebei Province from 2014 to August 2024, and to provide a scientific basis for the formulation of effective prevention and control measures.

The case report data of HFMD in Hebei Province from 2014 to August 2024 were extracted from the Chinese Disease Prevention and Control Information System. Descriptive epidemiological methods were used for analysis, and the incidence trend of HFMD was predicted by the ARIMA model.

A total of 371 393 cases of HFMD were reported with 26 deaths from 2014 to August 2024. The average annual incidence and mortality rates were 45.279 1 per 100 000 and 0.003 2 per 100 000, respectively. The incidence rate of HFMD decreased year by year, as did the number of severe cases and deaths. The disease showed a clear seasonal pattern, with a high incidence period from May to July every year. The incidence rates in Langfang, Baoding, and Chengde were high. Children aged 1-4 were the most susceptible group, with more male cases than female. Enterovirus 71, Coxsackievirus A16, and other enteroviruses accounted for 20.62%, 26.87%, and 52.51%, respectively. Using the SARIMAX model to predict the number of HFMD cases from September 2024 to August 2025, which would decrease first and then increase. And the seasonal peak of incidence in 2025 would be higher than that in 2024.

The incidence rate of HFMD in Hebei Province has shown a downward trend, but the peak in 2025 is predicted to be higher than that in 2024. It is necessary to strengthen the monitoring of the epidemic and etiology, scientifically formulate prevention and control plans, and prepare for the response.

To describe the clinical characteristics and ATP7B gene mutation spectrum of neurologic Wilson’s disease (WD) patients in southwest China and to explore genotype-phenotype correlations.

A total of 74 patients with neurologic WD admitted to West China Fourth Hospital of Sichuan University between August 2023 and July 2024 were enrolled. Patient demographics, clinical manifestations, and ATP7B gene mutation features were collected. Patients were stratified by mutation type to analyze associations between p.R778L, p.P992L, and loss-of-function (LOF) mutations and common initial symptoms or age at onset. Group comparisons were performed using Mann-Whitney U test, Kruskal-Wallis H test, Chi-square tests, or Fisher’s exact test as appropriate.

The median age at onset among 74 neurologic WD patients was 17.0 years (15.0, 25.8). The most common initial symptoms were tremor (67.6%) and dysarthria (36.5%). At enrollment, the predominant clinical manifestations were dystonia (77.0%), dysarthria (75.7%) and tremor (74.3%), with 44 patients having progressed to cirrhosis. Significant age or gender-related differences were observed in both initial and current symptoms. Genetic analysis revealed that the most frequent pathogenic mutations were p.R778L (28.08%) and p.P992L (18.49%). A total of 44 distinct pathogenic mutation combinations were detected, with the most common being p.R778L/p.R778L (11.3%) and p.R778L/p.P992L (9.9%). Genotype-phenotype analysis showed that LOF mutations were associated with earlier age at onset and dysarthria. No statistically significant correlations were found between p.R778L, p.P992L mutations and clinical phenotypes.

Neurologic WD patients exhibit significant clinical heterogeneity. p.R778L and p.P992L are the most common pathogenic mutations, while LOF mutations correlate with earlier age at onset and dysarthria. Clinicians should remain vigilant toward diverse initial symptoms and multi-system involvement in neurologic WD patients, emphasize individualized treatment strategies, and prioritize ATP7B gene testing to optimize precision diagnosis.

To investigate the mediating role of life satisfaction in the relationship between different types of leisure activities and cognitive function among rural older adults in Guizhou Province.

In July-August 2022, a face-to-face questionnaire survey was conducted in 12 villages across 2 counties in Guizhou Province, targeting at adults aged 60 and above. Using a self-administered questionnaire, Mini-mental State Examination(MMSE), and Satisfaction With Life Scale(SWLS), data was analyzed via descriptive statistics, partial correlation, and multiple regression. Mediation was assessed using the “mediation” package in R 4.3.1 and validated via the Bootstrap method.

A total of 1 298 adults aged 60 years and above were included in this study. The average score for cognitive function was 20.29±5.96, and the average score for life satisfaction was 26.41±4.61. Leisure activities were categorized into family-oriented and non-family-oriented types, with average scores of 8.64±3.04 and 8.86±2.55, respectively. Both types of leisure activities were positively correlated with life satisfaction and cognitive function (P<0.05). Life satisfaction partially mediates the relationship between family-oriented leisure activities and cognitive function, with an indirect effect of 0.059 (95% CI: 0.032-0.090), accounting for 13.4% of the total effect. This indirect effect is significant in elderly women (0.116, 95% CI: 0.064-0.170), representing 26.3% of the total effect, but not in elderly men.

In Guizhou Province, life satisfaction mediated the link between family-oriented leisure activities and cognitive function among rural older women. Strengthening support for rural older adults’ leisure activities can enhance their life satisfaction and cognitive function.

To explore the mediating role of emotional exhaustion in the relationship between workload and turnover intention among grassroots disease control and prevention staff, and the regulatory effect of policy perception.

A total of 1 108 District CDC staffs in Wuhan were selected by general survey in January 2024, and descriptive statistical analyses, regression analyses, and moderated mediated effects analyses were conducted.

(1) Workload could not directly affect the turnover intention in grassroots CDC staff (β= -0.031, P>0.05). (2) Emotional exhaustion played complete mediating roles between workload and turnover intention (95% CI: 0.269-0.371), with mediating effect size of 0.318. (3) Policy perception played a moderating role in the former half of the pathway of the aforementioned mediation model (β= -0.085, 95% CI: -0.170--0.002).

There is a moderated mediating effect between workload and turnover intention in grassroots CDC staffs, and emotional exhaustion is the mediating variable between them. Policy perception buffered the influence of workload on emotional exhaustion. Therefore, reasonably controlling working hours and task volumes, guiding grassroots disease control personnel to alleviate negative emotions, and enhancing their positive perception of the reform known as “public welfare first-class security, public welfare second-class management” can help reduce the level of intention to leave.

To analyze the current situation of job burnout among family doctors in primary medical and health institutions in Sichuan Province and its influencing factors.

From July to September 2024, through the stratified random cluster sampling method, 588 family doctors from 15 primary medical and health institutions in 5 counties (cities and districts) in Sichuan Province were selected as the survey subjects. The basic information and job burnout of family doctors were investigated by using maslach burnout inventory human service survey.The χ² test or Fisher’s exact probability method was used to analyze the detection rates of job burnout amongfamily doctors with different characteristics, and the influencing factors of job burnout among family doctors were analyzed by using binary logistic regression.

The M-values of the scores of the three dimensions of emotional exhaustion, emotional alienation and personal achievement among family doctors in primary medical and health institutions in Sichuan Province were 25 points, 8 points and 41 points respectively. Job burnout was detected in 430 family doctors, with a detection rate of 73.13%.The detection rates of mild, moderate and severe were 34.69% (204 doctors), 35.88% (211 doctors) and 2.55% (15 doctors), respectively. Binary logistic regression analysis showed that compared with those aged 20-29, family doctors aged 40-49(OR=0.312,95% CI:0.178-0.548) and 50-59(OR=0.473,95% CI:0.242-0.926) had a lower risk of job burnout. Compared with those with contracted service numbers ≤2 000, family doctors with contracted service numbers ≥5 001 had a higher risk of job burnout(OR=2.345, 95% CI: 1.276-4.308). Frequent overtime work was a risk factor for job burnout in family doctors(OR=1.587, 95% CI: 1.042-2.418).Family doctors with an average annual total income of more than 50 001 yuan had a lower probability of being detected job burnout than those with an average annual total income of no more than 50 000 yuan (OR=0.558,95% CI:0.370-0.842).

The current situation of job burnout among family doctors in primary medical and health institutions in Sichuan Province is not optimistic. Effective measures should be taken from multiple dimensions to alleviate the job burnout of family doctors, and continuous dynamic monitoring should be carried out at the same time.

To explore the association ofbody mass index (BMI), body roundness index (BRI), waist circumference (WC), and waist hip ratio (WHR) with the risk of all-cause mortality in a community-based cohort.

This study was based on a prospective cohort study conducted in Pudong New Area. Obesity-related indicators were obtained at the baseline survey, mortality data was collectedduring the follow-up period.The associations between BMI, BRI, WC, WHR and the risk of all-cause mortality were assessed using cox proportional hazard model, restricted cubic spline (RCS) regression model, and receiver operator characteristic (ROC) curve.

A total of 9 448 participants was included in the analysis. The median follow-up time was 10.77 years, during which 987 deaths occurred,the all-cause mortality was 10.08/1 000 person-years.After multi-variable adjustment,the HR(95% CI) of elevated BRI, WC, and WHR were 1.07(1.01-1.14), 1.12(1.05-1.20), and 1.14(1.07-1.21), respectively.There were U-shaped dose-response relationship betweenBMI, BRI, WC and all-cause mortality; and alinear dose-response relationshipbetween WHR and all-cause mortality. BRI had the highest accuracy in predicting all-cause mortality, with the AUC of 0.62(95% CI=0.60-0.64).

Obesity is a significant risk factor for all-cause mortality, proper control of obesity and fat distribution can help reduce the risk of all-cause mortality.

To analyze and compare the characteristics of comorbidity patterns in skeletal fluorosis patients across different endemic regions, laying the foundation for further research on influencing factors, while providing references for healthcare systems to develop more targeted, effective, and cost-efficient chronic disease management plans for this special population.

This study adopted a cross-sectional design, selecting patients over 40 years old with skeletal fluorosis from Nayong County, Guizhou Province (a coal-burning fluorosis endemic area), Jishan County, Shanxi Province (a water-drinking fluorosis endemic area), and Ruoergai County, Sichuan Province (a tea-drinking fluorosis endemic area) as research subjects. The Apriori algorithm was used to analyze the dataset, and indicators such as the minimum conditional support were set to derive disease association rules. Additionally, Yule’s Q method was applied for systematic cluster analysis, and a dendrogram was drawn to explore the comorbidity patterns of chronic diseases in the elderly.

In the coal-burning type disease area, patients aged over 70 accounted for the highest proportion (43.55%), and the prevalence rates of chronic kidney disease (12.61%), hypertension (33.24%), and cholelithiasis/cholecystosis (11.89%) were higher than those in the drinking-water type and tea-drinking type disease areas. The tea-drinking type disease area was dominated by individuals aged 50-60 years (38.57%), with the highest prevalence of other bone diseases (68.93%). The drinking-water type disease area had the largest proportion of patients aged 60-70 years (43.04%).Comorbidity analysis showed that the coal-burning type disease area had the highest comorbidity rate (43.98%). In terms of comorbidity patterns, the most typical combination of two concurrent diseases was diabetes-coronary heart disease, while the combination of three concurrent diseases was mainly diabetes-coronary heart disease-hypertension. The tea-drinking type disease area had a comorbidity rate of 34.29%, with the main two-disease comorbidity pattern being coronary heart disease-cholelithiasis/cholecystosis, and the three-disease comorbidity pattern adding other bone diseases to the above combination. The drinking-water type disease area had the lowest comorbidity rate (21.43%), with the main two-disease comorbidity being cholelithiasis/cholecystosis-stroke, and the three-disease comorbidity pattern being stroke combined with diabetes and hypertension.Cluster analysis independently showed that the coal-burning type disease area could be clustered into 6 categories (dominated by metabolic cardiovascular diseases), the tea-drinking type disease area into 4 categories (highlighting metabolic skeletal diseases), and the drinking-water type disease area into 5 categories (characterized by multi-system metabolic inflammatory diseases).

There are significant differences in the comorbidity patterns of skeletal fluorosis patients among coal-burning, tea-drinking, and water-drinking fluorosis endemic areas. The coal-burning endemic area is dominated by metabolic and cardiovascular diseases such as diabetes, coronary heart disease, and hypertension. In the tea-drinking endemic area, there is a significant association between coronary heart disease and gallstones/gallbladder cysts, as well as a comorbidity pattern of diabetes and pulmonary tuberculosis. The water-drinking endemic area is characterized by the association between gallstones/gallbladder cysts and stroke; meanwhile, the combination of kidney disease and metabolic diseases highlights multisystem damage.

To analyze the information of aquatic products that were not allowed to enter the country from 2019 to 2024, and put forward suggestions for ensuring the quality and safety of imported aquatic products.

The data of aquatic products that were not allowed to enter the country during the period from 2019 to 2024, as published by the General Administration of Customs, were sorted out and analyzed.

Form 2019 - 2024, there were a total of 3 798 batches of aquatic products were not allowed to enter the country; and they involved 62 importing countries and regions, with products from Ecuador accounting for as high as 21.94% of the total.The number of involved production enterprises reached 1 190, among which the enterprises from Vietnam, India, Indonesia, Ecuador and Pakistan accounted for more than 48% of the total.The main types of aquatic products that were not allowed to enter the country were crustaceans (HS0303) and frozen fish (HS0306), accounting for 64.98% of the total.There are 11 reasons for nonconformity, with the top three being inspection and quarantine (35.27%), certificates (27.80%) and food additives (17.52%). There are 7 nonconformity indicators related to food safety, with the top three being food additives (17.60%), quality (4.12%) and heavy metals (2.68%).

From 2019-2024, the number of batches of aquatic products that were not allowed to enter the country showed an overall increasing trend. The source countries, production enterprises, food categories, reasons for non-compliance, and non-compliance items related to food safety of the aquatic products that were not allowed to enter the country showed relatively concentrated distribution characteristics.