Objective: To explore the influence of Tongfei Pingxiao Decoction combined with acupoint acupuncture on TCM syndromes, serum immunoglobulin (Ig) E, intercellular adhesion molecule 1 (ICAM - 1) and interferon - γ (IFN - γ) in children with acute attack of bronchial asthma (BA).Methods: 144 children with BA acute attack of heat wheezing admitted to Jingzhou Hospital of Traditional Chinese Medicine Hospital were selected from October 2023 to October 2024 as the research subjects. According to the random number table method, the above children were divided into control group and observation group, 72 cases in each group. Both groups were given routine treatment, and the control group was treated with acupoint acupuncture, whereas the observation group was combined with Tongfei Pingxiao Decoction on the basis of the control group. The clinical efficacy and safety in the two groups were evaluated, and the differences in TCM syndromes scores, lung function [forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), peak expiratory flow (PEF)], serum IgE, ICAM - 1 and IFN - γ levels were analyzed in both groups.Results: The observation group had significantly higher total effective rate than the control group (P < 0.05). After treatment, the scores of wheezing, cough, runny nose, tongue and pulse and levels of serum IgE and ICAM - 1 in both groups were significantly decreased, and the above scores and levels in observation group were significantly lower than those in control group (P <0.05). The lung function indexes such as FVC, FEV1%, PEFR% and serum IFN- γ were significantly increased in the two groups after treatment, and the indexes were significantly higher in observation group (P < 0.05).Conclusion: Based on the conventional western medicine treatment, Tongfei Pingxiao Decoction combined with acupoint acupuncture can effectively improve the clinical symptoms and lung function of children with acute attack of BA. The role mechanism may be related to the regulations of serum IgE, IFN - γ and ICAM - 1.

Objective: To investigate the therapeutic effects and mechanisms of Yinhuang Lotion on wound healing in diabetic ulcer rats.Methods: A diabetic model was established in SD rats using a high - sugar, high - fat diet combined with a single intraperitoneal injection of streptozotocin (STZ). A diabetic skin ulcer model was then created through surgical intervention and stimulation with 50% glacial acetic acid. The successfully modeled rats were randomly divided into a model group, a Yinhuang Lotion group, and a Kangfuxin Liquid group, with 12 rats in each group. An additional 12 normal SD rats served as the control group. The ulcer wounds of the control and model groups were covered with gauze soaked in normal saline. The Yinhuang Lotion group received gauze soaked in Yinhuang Lotion, while the Kangfuxin Liquid group was treated with gauze soaked in Kangfuxin Liquid. All groups underwent daily dressing changes for 28 days. On days 14 and 28, six rats from each group were randomly selected to assess general condition, body weight, fasting blood glucose, ulcer area, and ulcer healing rate. Serum levels of interleukin - 18 (IL - 18) and tumor necrosis factor - α (TNF - α) were measured using ELISA, while the expression levels of hypoxia - inducible factor 1α (HIF - 1α) and vascular endothelial growth factor (VEGF) were detected via Western blot.Results: On days 14 and 28, compared with the control group, the model group exhibited larger ulcer areas, lower ulcer healing rates, higher levels of inflammatory factors, and reduced expression of related proteins (P <0.05). In contrast, the Yinhuang Lotion and Kangfuxin Liquid groups showed smaller ulcer areas, higher ulcer healing rates, lower inflammatory factor levels, and increased expression of related proteins (P <0.05). Furthermore, on days 14 and 28, the Yinhuang Lotion group demonstrated significantly smaller ulcer areas (P <0.01), higher ulcer healing rates (P < 0.01), lower inflammatory factor levels (P <0.01), and higher expression of related proteins (P < 0.01) compared with the Kangfuxin Liquid group.Conclusion: Yinhuang Lotion can promote angiogenesis in ischemic wounds, accelerate tissue repair, and shorten the treatment period for diabetic ulcers by inhibiting inflammatory factors and regulating the HIF - 1α/VEGF signaling pathway, thereby effectively treating diabetic ulcer wounds.

Objective: To explore the clinical effect of Shenghui Decoction on vascular dementia with kidney essence deficiency.Methods: A total of 110 VD patients with kidney essence deficiency syndrome admitted to the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from January 2023 to June 2024 were selected and divided into the control group and the observation group according to different clinical treatment methods, with 55 cases in each group. The control group was treated with conventional western medicine (nimodipine + piracetam), and the observation group was treated with western medicine combined with Shenhui decoction. The efficacy, TCM symptoms, cognitive function [Dementia Rating Scale (CDR), Mini - Mental State Examination (MMSE)], oxidative stress [nitrotyrosine(NT), reduced glutathione (GSH), total antioxidant capacity (T - AOC)], neurological function [neurofilament light chain polypeptide (NF - L), B - cell lymphoma - 2 (Bcl - 2), neuronal nitric oxide synthase (nNOS), brain- derived neurotrophic factor (BDNF)] and medication safety were compared between the two groups.Results: The efficacy of the observation group was higher than that of the control group (P < 0.05). After treatment, the TCM symptom scores, CDR scores, and levels of NT, NF - L and nNOS in the two groups were reduced, and the reduction was more significant in the observation group (P <0.05). After treatment, the MMSE score, GSH, T - AOC, Bcl - 2 and BDNF levels of the two groups increased, and the observation group increased more significantly (P <0.05). There was no significant difference in medication safety between the two groups (P > 0.05).Conclusion: Modified Shenghui Decoction is safe and effective in treating VD with kidney essence deficiency syndrome. It can not only promote the recovery of neurological function and reduce oxidative stress damage but also improve patients' cognitive function and enhance the overall clinical efficacy.

Objective: To investigate the intervention effect of Feijin Mixture on airway mucus hypersecretion in mice with cough variant asthma (CVA).Methods: Mice were divided into five groups: control group, model group, low- dose Feijin Mixture group, high - dose Feijin Mixture group, and prednisone group. A CVA mouse model was established by sensitization and challenge with ovalbumin (OVA) and aluminum hydroxide [Al(OH)₃]. Mice in the control and model groups were administered normal saline by gavage, while mice in the treatment groups received corresponding doses of drugs. Pathological changes in lung tissue were detected by hematoxylin - eosin (HE) staining. Mucin content secreted by tracheal epithelial cells was observed by Alcian blue - periodic acid - Schiff (AB - PAS)staining. Mucin 5AC (Mucin5AC) content in lung tissue was detected by immunohistochemistry. Tumor necrosis factor - α (TNF - α) levels in lung tissue and bronchoalveolar lavage fluid, as well as serum levels of interleukin - 4(IL - 4) and interleukin-8 (IL - 8), were measured by enzyme - linked immunosorbent assay (ELISA). Epidermal growth factor receptor (EGFR) expression in lung tissue was detected by Western blot.Results: Compared with the model group, the Feijin Mixture groups showed reduced bronchial epithelial goblet cell hyperplasia, inflammatory cell infiltration around the respiratory tract and bronchi and blood vessels, and reduced fibroblast hyperplasia in alveolar walls of the respiratory region. The number of goblet cells, Mucin5AC content, PAS - positive staining area, TNF - α, IL - 4, IL - 8, and p - EGFR/EGFR expression in lung tissue were decreased in the Feijin Mixture groups (P <0.05).Conclusion: Feijin Mixture can reduce the expression of airway mucin - like proteins, alleviate pathological changes and inflammatory responses, thereby effectively intervening in airway mucus hypersecretion through the TNF - α/EGFR pathway.

Chronic musculoskeletal pain (CMP) is the most common type of chronic pain and includes cervical spondylosis, frozen shoulder, knee osteoarthritis, myofascial pain syndrome, rheumatoid arthritis, and fibromyalgia. At present, the clinical treatment of CMP is mainly based on drug therapy, but there are many adverse reactions in the treatment of Western medicine and there are differences in drug efficacy between different indications. Acupotomy therapy combines the advantages of traditional Chinese medicine acupuncture and Western medical surgical therapy, and is widely used in the treatment of CMP in clinical practice. Acupotomy therapy can improve the structure and function of the musculoskeletal system, affect the conduction of pain, and reduce inflammation through local release, thereby relieving pain and improving limb function. This article summarizes the application and progress of the underlying mechanisms of Acupotomy therapy in the field of CMP, aiming to provide a reference for the prevention and treatment of CMP and the clinical application of Acupotomy therapy.

Objective: To observe and analyze the clinical efficacy of Professor Wu Min's anti - allergy Formula from from Shanghai - style Xu's Pediatrics in treating pediatric allergic rhinitis.Methods: A total of 136 pediatric patients with allergic rhinitis treated at Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine and Youyi Community Health Service Center from December 2020 to December 2023 were collected and randomly divided into a treatment group (68 cases, loratadine tablets + anti - allergy Formula) and a control group (68 cases, loratadine tablets). Serum immune indicators and inflammatory factor levels in nasal secretions were measured and compared between the two groups. Symptom improvement and clinical efficacy were evaluated, and adverse reactions were recorded.Results: After treatment, the total serum immunoglobulin (Ig) E and the ratio of helper T cells (Th) 17/regulatory T cells (Treg) in the treatment group were significantly lower than those in the control group (P < 0.05). The interleukin (IL) - 4 level in nasal secretions of the treatment group was significantly lower than that of the control group (P <0.05), while the IL - 10 level was significantly higher (P < 0.05). After treatment, the scores for nasal congestion, nasal itching, runny nose, and sneezing in the treatment group were significantly lower than those in the control group (P <0.05). The total effective rate in the treatment group was significantly higher than that in the control group (P < 0.01). There was no significant difference in the incidence of adverse reactions such as gastrointestinal symptoms and skin reactions between the treatment group and the control group (P >0.05).Conclusion: Professor Wu Min's anti - allergy Formula is highly effective in treating pediatric allergic rhinitis, regulating immune function, reducing inflammatory responses, alleviating symptoms such as nasal congestion and itching, and demonstrating high safety.

Objective: To analyze the clinical efficacy of acupoint application combined with doxycycline in the treatment of mycoplasma pneumoniae pneumonia (MPP) complicated with lung consolidation in children with phlegm - heat obstructing the lung syndrome.Methods: A total of 120 children with MPP complicated with lung consolidation and phlegm - heat obstructing the lung syndrome, admitted to Shandong University Qilu Hospital Dezhou Hospital from August 2022 to August 2024, were selected. They were divided into a control group (doxycycline) and an observation group (control group treatment plus acupoint application) using a random number table method, with 60 cases in each group. The treatment course was 10 days. The therapeutic efficacy, symptom disappearance time, hospitalization duration, traditional Chinese medicine (TCM) syndrome scores, inflammatory factors [D - dimer (D - D), interleukin - 6(IL - 6), erythrocyte sedimentation rate (ESR), immunoglobulin - E (IgE), and C - reactive protein (CRP)], and adverse reactions were observed in both groups.Results: The total effective rate in the observation group was higher than that in the control group (P < 0.05). The time to symptom disappearance and the hospitalization duration in the observation group were shorter than those in the control group (P < 0.05). After treatment, the TCM syndrome scores and serum levels of inflammatory factors in the observation group were lower than those in the control group (P <0.01). There was no statistically significant difference in adverse reactions between the two groups (P > 0.05).Conclusion: Acupoint application combined with doxycycline for treating MPP complicated with lung consolidation in children with phlegm - heat obstructing the lung syndrome can alleviate symptoms and inflammatory injury and shorten the hospitalization duration, representing an effective and safe treatment regimen.

Objective: To explore the mechanism of Bushen Jiangzhi Formula in intervening atherosclerosis (AS) in Apoe⁻/⁻ mice based on comprehensive tissue metabolomics.Methods: Apoe⁻/⁻ mice were fed a high - fat diet to establish an AS model and randomly divided into model (M) group, Bushen (BS) group, and atorvastatin (ATV)group, with age - matched C57BL/6J mice as normal control (C) group. After 12 weeks of intervention, ultra - high - performance liquid chromatography - tandem mass spectrometry (UHPLC - MS/MS) combined with UPLC - Orbitrap mass spectrometry - based untargeted lipidomics was used to detect aortic metabolites and lipids. Bioinformatics analysis was performed to identify signature differential metabolites and lipids.Results: High - fat diet induced typical AS lesions and lipid accumulation in the aortic sinus of Apoe⁻/⁻ mice. Aortic metabolites were mainly classified as lipids and lipid - like molecules. Compared with the M group, the BS group showed 7 upregulated and 2 downregulated differential metabolites in positive ion mode, and 12 upregulated and 3 downregulated in negative ion mode. Bushen Jiangzhi Formula reversed the expression trends of signature differential metabolites, including deoxythymidine 5' - phosphate(dTMP) and milnacipran. KEGG analysis indicated that dTMP was significantly enriched in the pyrimidine metabolism pathway. Lipidomics identified 3,897 lipid molecules belonging to 44 subclasses. Compared with the M group, the BS group exhibited 102 significantly upregulated and 24 downregulated differential lipid molecules. Bushen Jiangzhi Formula reversed the expression trends of 30 signature differential lipids related to phosphatidylserine (PS), triglyceride (TG), and lysophosphatidylcholine (LPC) subclasses. Correlation analysis revealed strong interrelationships among these signature lipids.Conclusion: The mechanism of Bushen Jiangzhi Formula in intervening AS in Apoe⁻/⁻ mice may involve regulating aortic metabolite dTMP through the pyrimidine metabolism pathway and modulating the expression of PS -, TG -, and LPC - related lipid molecules at the comprehensive tissue metabolomics level.

Objective: To investigate the efficacy of Chaihu plus Longgu and Muli Decoction combined with Huanglian Wendan Decoction in the treatment of phlegm - fire disturbing the heart type of intractable insomnia and its effect on sleep structure.Methods: Retrospectively selected 92 cases of recalcitrant insomnia patients treated in our hospital as research subjects, the selected time period is January 2022 - October 2024, according to the different treatment methods are divided into 40 cases in the control group (eszopiclone tablets) and 52 cases in the experimental group (control group + Chaihu plus Longgu and Muli Decoction combined with Huanglian Wendan Decoction). The clinical efficacy, TCM scores, sleep structure and sleep quality of the two groups were compared. Safety was analyzed for both groups.Results: After treatment, the effective rate of the experimental group was 96.15%, which was significantly higher than that of the control group, which was 80.00% (P < 0.05). After treatment, the scores of sleep and wakefulness, difficulty in falling asleep, sleeplessness after waking up, and restlessness and dreaminess in the experimental group were significantly lower than those in the control group (P <0.05). After treatment, the levels of rapid eye movement(REM) and non - rapid eye movement (N3) were significantly higher in the experimental group than in the control group (P < 0.05); the levels of non - rapid eye movement (N1) and non - rapid eye movement (N2) were significantly lower in the experimental group than in the control group (P < 0.05). After treatment, patients in the experimental group had significantly lower pulmonary daytime dysfunction, sleep onset, sleep duration, sleep disorder, sleep quality, sleep effectiveness and total score than those in the control group (P < 0.05). After treatment, the incidence of adverse reactions in the experimental group was 15.38% (8/52), higher than the control group's 10.00%(4/40), but there was no significant difference between the two groups (P > 0.05).Conclusion: The combination of traditional Chinese medicine and western medicine (based on the treatment of estazolam tablet and Chaihu plus Longguand Muli Decoction combined with Huanglian Wendan Decoction) has a significant synergistic effect on refractory insomnia of phlegm fire disturbing heart type, which can not only achieve more satisfactory curative effect, but also effectively improve the symptoms of traditional Chinese medicine, significantly improve the sleep quality, optimize the sleep structure, and have higher safety, reflecting the advantages of integrated traditional Chinese and western medicine in the treatment of this disease.

Objective: To investigate the therapeutic effect of the Spleen - strengthening, Dampness - eliminating, and Turbidity - resolving Formula on patients with Spleen deficiency and damp - phlegm type polycystic ovary syndrome(PCOS) complicated by insulin resistance (IR).Methods: A total of 104 patients diagnosed with Spleen deficiency and damp - phlegm type PCOS complicated by IR were selected from Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine between April 2021 and April 2024. They were randomly assigned to the control group (n = 52, conventional treatment) and the Traditional Chinese Medicine (TCM) group (n = 52, receiving Spleen - strengthening, Dampness - eliminating and Turbidity - resolving Formula in addition to the control group treatment). Hormonal indicators, glucose and lipid metabolism indicators, TCM syndrome scores, imaging indicators, and the incidence of adverse reactions were compared before and after treatment.Results: After treatment, the FSH level in the TCM group was higher than that in the control group, while the levels of LH, AMH, LH/FSH, FPG, FINS, and HOMA - IR were lower (P < 0.05). The TCM group also showed lower scores for symptoms such as loose stools, diarrhea, loss of appetite, and fatigue compared to the control group (P < 0.05). Additionally, the ovarian volume and number of follicles in the TCM group were lower, while the endometrial thickness was higher than those in the control group (P <0.05). The incidence of adverse events in the TCM group did not differ statistically from that in the control group (P >0.05).Conclusion: The spleen - strengthening, dampness - eliminating, and turbidity - resolving formula can significantly improve metabolic status and enhance insulin sensitivity in patients with spleen - deficiency and phlegm- dampness type PCOS combined with IR. It is safe and holds great potential for broad clinical application and precision medicine.