Objective: To investigate the differences in clinical blood indicators among infants with cytomegalovirus(CMV) hepatitis of different Traditional Chinese Medicine (TCM) syndromes, providing reference for clinical syndrome differentiation.Methods: A total of 120 infants meeting the diagnostic criteria for cytomegalovirus hepatitis were consecutively enrolled from Beijing Children's Hospital, Capital Medical University, from Febuary 2022 to Febuary 2024, including 40 cases each of dampness - heat internal accumulation syndrome, spleen deficiency with dampness retention syndrome, and qi stagnation with blood stasis syndrome. Differences in red blood cell parameters, platelet parameters, coagulation function, and liver function indicators were compared among the syndromes.Results: No significant differences were found in gender or age among the groups (P >0.05). The disease duration was longer in the spleen deficiency with dampness retention group and qi stagnation with blood stasis group compared to the dampness- heat internal accumulation group (P < 0.01). Regarding liver function, the qi stagnation with blood stasis group had higher GGT levels than the dampness - heat internal accumulation group (P <0.01), while the spleen deficiency with dampness retention group showed higher ALT levels (P <0.01). Both spleen deficiency with dampness retention and qi stagnation with blood stasis groups exhibited higher AST, TBIL, DBIL, and TBA levels than the dampness - heat internal accumulation group (P <0.05, P < 0.01). The qi stagnation with blood stasis group had higher TBIL, DBIL, and TBA levels than the spleen deficiency with dampness retention group (P <0.01). In red blood cell parameters, the spleen deficiency with dampness retention and qi stagnation with blood stasis groups showed lower RBC, HGB, and HCT but higher RDW compared to the dampness - heat internal accumulation group (P <0.05, P < 0.01). Platelet analysis revealed higher PLT in the qi stagnation with blood stasis group than in the spleen deficiency with dampness retention group (P <0.01). Coagulation tests demonstrated longer PT and higher INR in the qi stagnation with blood stasis group(P < 0.01) but lower FIB (P <0.05) versus the dampness - heat internal accumulation group. The spleen deficiency with dampness retention group had prolonged APTT (P < 0.05).Conclusion: Significant differences exist in blood indicators among different TCM syndromes of infantile cytomegalovirus hepatitis, providing a theoretical basis for clinical syndrome differentiation.

Objective: To explore the influence of Tongfei Pingxiao Decoction combined with acupoint acupuncture on TCM syndromes, serum immunoglobulin (Ig) E, intercellular adhesion molecule 1 (ICAM - 1) and interferon - γ (IFN - γ) in children with acute attack of bronchial asthma (BA).Methods: 144 children with BA acute attack of heat wheezing admitted to Jingzhou Hospital of Traditional Chinese Medicine Hospital were selected from October 2023 to October 2024 as the research subjects. According to the random number table method, the above children were divided into control group and observation group, 72 cases in each group. Both groups were given routine treatment, and the control group was treated with acupoint acupuncture, whereas the observation group was combined with Tongfei Pingxiao Decoction on the basis of the control group. The clinical efficacy and safety in the two groups were evaluated, and the differences in TCM syndromes scores, lung function [forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), peak expiratory flow (PEF)], serum IgE, ICAM - 1 and IFN - γ levels were analyzed in both groups.Results: The observation group had significantly higher total effective rate than the control group (P < 0.05). After treatment, the scores of wheezing, cough, runny nose, tongue and pulse and levels of serum IgE and ICAM - 1 in both groups were significantly decreased, and the above scores and levels in observation group were significantly lower than those in control group (P <0.05). The lung function indexes such as FVC, FEV1%, PEFR% and serum IFN- γ were significantly increased in the two groups after treatment, and the indexes were significantly higher in observation group (P < 0.05).Conclusion: Based on the conventional western medicine treatment, Tongfei Pingxiao Decoction combined with acupoint acupuncture can effectively improve the clinical symptoms and lung function of children with acute attack of BA. The role mechanism may be related to the regulations of serum IgE, IFN - γ and ICAM - 1.

Objective: To explore the clinical effect of Shenghui Decoction on vascular dementia with kidney essence deficiency.Methods: A total of 110 VD patients with kidney essence deficiency syndrome admitted to the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from January 2023 to June 2024 were selected and divided into the control group and the observation group according to different clinical treatment methods, with 55 cases in each group. The control group was treated with conventional western medicine (nimodipine + piracetam), and the observation group was treated with western medicine combined with Shenhui decoction. The efficacy, TCM symptoms, cognitive function [Dementia Rating Scale (CDR), Mini - Mental State Examination (MMSE)], oxidative stress [nitrotyrosine(NT), reduced glutathione (GSH), total antioxidant capacity (T - AOC)], neurological function [neurofilament light chain polypeptide (NF - L), B - cell lymphoma - 2 (Bcl - 2), neuronal nitric oxide synthase (nNOS), brain- derived neurotrophic factor (BDNF)] and medication safety were compared between the two groups.Results: The efficacy of the observation group was higher than that of the control group (P < 0.05). After treatment, the TCM symptom scores, CDR scores, and levels of NT, NF - L and nNOS in the two groups were reduced, and the reduction was more significant in the observation group (P <0.05). After treatment, the MMSE score, GSH, T - AOC, Bcl - 2 and BDNF levels of the two groups increased, and the observation group increased more significantly (P <0.05). There was no significant difference in medication safety between the two groups (P > 0.05).Conclusion: Modified Shenghui Decoction is safe and effective in treating VD with kidney essence deficiency syndrome. It can not only promote the recovery of neurological function and reduce oxidative stress damage but also improve patients' cognitive function and enhance the overall clinical efficacy.

Objective: To observe the clinical efficacy of oral Jianpi Shuyi Decoction in treating patients with chronic pancreatitis (CP) of liver depression and spleen deficiency syndrome.Methods: Using a randomized number table method, from September 2019 to July 2023 80 CP patients with liver depression and spleen deficiency syndrome who visited Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine were divided into a control group and an experimental group, with 40 cases in each group. The control group received Western medicine treatment, while the experimental group received the same plus Jianpi Shuyi Decoction. The treatment course was 4 weeks, and both groups were treated for 2 courses. The clinical efficacy, traditional Chinese medicine (TCM) symptom scores, abdominal pain visual analog scale (VAS) scores, laboratory indicators [serum amylase (AMS), lipase (LPS), fasting blood glucose (FBG)] levels, and the diameters of the main pancreatic duct and common bile duct were compared between the two groups.Results: After treatment, the total clinical effective rate in the experimental group was significantly higher than that in the control group (89.74% vs. 68.42%), with a statistically significant difference(P < 0.05). After treatment, abdominal pain, poor appetite, and pain - diarrhea symptoms in the control group were significantly reduced compared with those before treatment (P < 0.05). In the experimental group, abdominal pain, abdominal distension, poor appetite, depression and irritability, loose and sticky stools, and pain - diarrhea symptoms were significantly reduced compared with those before treatment (P < 0.05). Moreover, the scores for abdominal pain, abdominal distension, loose and sticky stools, and pain - diarrhea symptoms in the experimental group were significantly lower than those in the control group (P < 0.05). After treatment, the VAS scores of both groups were significantly reduced (P < 0.05), and the VAS score of the experimental group was significantly lower than that of the control group(P < 0.05). The AMS levels of both groups were significantly reduced (P < 0.05), and the experimental group was significantly lower than the control group (P < 0.05). No significant reduction in LPS level was observed in the control group (P > 0.05), while the LPS level in the experimental group was significantly reduced (P < 0.05) and significantly lower than that in the control group (P < 0.05). No significant reduction in FBG levels was observed in either group(P > 0.05), and there was no statistically significant difference between the two groups (P > 0.05). After treatment, the diameters of the main pancreatic duct and common bile duct in both groups showed no significant changes compared with those before treatment (P > 0.05).Conclusion: Jianpi Shuyi Decoction can effectively alleviate clinical symptoms such as abdominal pain, improve digestive function, reduce serum amylase and lipase levels, alleviate inflammatory responses, and demonstrate good safety in treating CP patients with liver depression and spleen deficiency syndrome.

Objective: To explore the clinical value of Yiqi Quxie Cangerzi Decoction combined with acupoint catgut embedding in the prophylactic treatment of patients with lung qi deficiency and cold type of seasonal allergic rhinitis.Methods: 168 patients with seasonal allergic rhinitis of lung qi deficiency and cold type in Zhangjiakou Hospital of Traditional Chinese Medicine were selected from May 2022 to October 2023, and were randomized into combined group, traditional Chinese medicine (TCM) group, catgut embedding group and control group by convenient sampling method, with 42 cases in each group. All four groups received prophylactic treatment 2 weeks before disease onset in each previous year, and the control group was treated with mometasone furoate nasal spray, and the TCM group was given oral administration of modified Yiqi Quxie Cangerzi Decoction, the catgut embedding group received acupoint catgut embedding, and the combined group adopted modified Yiqi Quxie Cangerzi Decoction combined with acupoint catgut embedding. The clinical efficacy was compared among the four groups of patients. The nasal symptoms and signs [total nasal symptom score (TNSS)], rhinitis accompanying symptoms [total non - nasal symptom score (TNNSS)] and quality of life [rhinoconjunctivitis quality of life questionnaire (RQLQ)] after 4 weeks and 8 weeks of treatment were evaluated. The adverse reactions and recurrence were observed in the four groups.Results: The effective rate in TCM group, catgut embedding group and combined group was obviously higher compared to control group (P <0.01). After 4 and 8 weeks of treatment, the scores of TNSS, TNNSS and RQLQ in TCM group, catgut embedding group and combined group were significantly lower than those in control group (P < 0.05). The recurrence rate was significantly lower in TCM group, catgut embedding group and combined group than that in control group (P <0.01). Only 2 cases of nasal bleeding occurred in control group, and no other obvious adverse reactions were found.Conclusion: Yiqi Quxie Cangerzi Decoction combined with acupoint catgut embedding therapy has a significant prophylactic treatment effect on seasonal allergic rhinitis of lung qi deficiency and cold type. Meanwhile, it can effectively improve the quality of life of patients, and it has low recurrence rate and low risk of adverse reactions.

Objective: To explore the clinical effect of Chaihu Longgu Muli Decoction on breast hyperplasia of liver qi stagnation syndrome and its influence on immune function.Methods: A total of 110 patients with mammary hyperplasia with liver - qi stagnation syndrome admitted to the First Affiliated Hospital of Anhui University of Chinese Medicine from July 2023 to July 2024 were selected and divided into 2 groups according to treatment methods, with 55 cases each. The control group was treated with conventional Western medicine, and the observation group was treated with conventional Western medicine combined with bupleurum keel and oyster soup. The efficacy, TCM syndrome score, improvement of breast mass, serum neurotransmitter indexes [5 - hydroxytryptamine (5 - HT), dopamine (DA)], estrogen indexes[estradiol (E₂), prolactin (PRL), progesterone (P)], immune function indexes and drug safety were compared between the two groups.Results: Compared with the control group, the observation group had higher efficacy and less adverse reactions (P < 0.05). After treatment, the scores of main syndrome, secondary syndrome, mass maximum diameter and visual analogue scale (VAS) were decreased in both groups, and the decrease was more obvious in the observation group (P <0.05). After treatment, the levels of E₂, PRL, 5 - HT and DA were decreased in both groups, the decrease was more obvious in the observation group, the levels of P, CD3⁺ and CD4⁺/CD8⁺ were increased in both groups, and the increase was more obvious in the observation group (P < 0.05).Conclusion: Chaihu Longgu Muli Decoction is used for clinical treatment of mammary hyperplasia of liver qi stagnation syndrome. It can improve clinical symptoms, breast mass and sex hormone levels, regulate serum neurotransmitter and immune function, improve clinical efficacy and drug safety.

Objective: To analyze the application value of the self - designed Xuanfei Tongqiao Decoction combined with acupoint application in the clinical efficacy, inflammatory factors, immune function and prognosis of children with allergic rhinitis. Method: The research subjects were 186 children with allergic rhinitis who were diagnosed and treated in our hospital from September 2022 to August 2024. They were divided into the control group (n = 93) and the observation group (n =93) by the random number table method. The control group was treated with loratadine syrup, while the observation group was treated with self - designed Xuanfei Tongqiao Decoction combined with acupoint application. Both groups were treated for 2 months. Compare the clinical efficacy of the two groups; The levels of inflammatory factors, immune function indicators, TCM syndrome scores and quality of life scores of the two groups of children before and after treatment were compared; Compare the incidence of adverse reactions after treatment between the two groups of children.Results: Compared with the control group, the total effective rate of clinical treatment of the children was significantly increased in the observation group (P < 0.01). After treatment, the levels of C - reactive protein (CRP), tumor necrosis factor α (TNF - α) and interleukin - 6 (IL - 6) were significantly decreased in the observation group compared with the control group (P <0.01). Compared with the control group, the immunoglobulin E(IgE) and eosinophils (EOS) counts were significantly decreased in the observation group after treatment, and the CD4⁺/CD8⁺ levels were significantly increased in the observation group (P < 0.01). Compared with control group, TCM syndrome score and allergic rhinitis Quality of Life questionnaire (RQLQ) score were significantly decreased in observation group after treatment (P <0.01). Compared with the control group, the total incidence of adverse reactions after treatment was significantly reduced in the observation group (P <0.05).Conclusion: The self - proposed Xuanfei Tongqiao Decoction combined with acupoint application has a high clinical efficacy for children with allergic rhinitis. It can effectively improve the inflammatory response, immune function, TCM syndrome score and quality of life of the children, and has high safety.

Objective: To investigate the effect of eliminating phlegm and promoting blood circulation method combined with Western medicine in treating diabetic peripheral neuropathy (DPN) with the pattern of phlegm - dampness obstructing collaterals.Methods: A total of 92 DPN patients with the pattern of phlegm - dampness obstructing collaterals admitted to Xuchang People's Hospital from January 2021 to November 2023 were selected as study subjects and divided into a combination group and a control group according to a random number table, with 46 cases in each group. In this study, 3 cases in the combination group dropped out/were excluded (2 withdrew voluntarily, 1 did not take medication as required by the study), and 4 cases in the control group dropped out/were excluded (1 withdrew voluntarily, 2 did not take medication as required by the study, 1 had worsened condition requiring other treatment plans). Finally, 43 patients were included in the combination group and 42 in the control group. The control group was treated with Western medicine, while the combination group was additionally treated with the method of eliminating phlegm and promoting blood circulation. Neurological function, nerve conduction velocity, traditional Chinese medicine(TCM) symptom scores, and oxidative stress indicators were compared between the two groups before and after treatment. Clinical efficacy and medication safety were also compared between the two groups.Results: After treatment, malondialdehyde (MDA), Toronto Clinical Scoring System (TCSS) scores, and TCM symptom scores decreased in both groups (P <0.05, P < 0.01), and the combination group was lower (P < 0.05, P < 0.01). Superoxide dismutase(SOD), reduced glutathione (GSH), and nerve conduction velocity increased in both groups after treatment (P <0.05), and the combination group was higher (P <0.05). The total effective rate in the combination group was higher than that in the control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05).Conclusion: The method of eliminating phlegm and promoting blood circulation combined with Western medicine can effectively improve TCM symptoms, enhance neurological function, reduce oxidative stress, and demonstrate significant clinical efficacy with a low risk of adverse reactions in treating DPN with the pattern of phlegm - dampness obstructing collaterals.

Objective: To investigate the effects of Shuhua Guwei Decoction combined with bacterial lysates on pulmonary function and immune function in children with recurrent respiratory tract infections (RRTI) and lung - spleen qi deficiency pattern.Methods: A total of 118 children with RRTI and lung - spleen qi deficiency pattern admitted to Qinhuangdao Hospital of Dongfang Hospital, Beijing University of Chinese Medicine, from March 2022 to March 2024 were selected and divided into a control group (treated with bacterial lysates) and an observation group (treated with Shuhua Guwei Decoction in addition to the control group treatment) according to a random number table method. The clinical efficacy, traditional Chinese medicine (TCM) syndrome scores, pulmonary function indicators, immune function indicators, inflammatory indicators, and incidence of adverse reactions were compared between the two groups.Results: After 4 weeks of treatment, the total effective rate in the observation group was 91.53% (54/59), which was higher than that in the control group (72.88%, 43/59), and the difference was statistically significant (P < 0.01). After treatment, the TCM syndrome scores in the observation group were lower than those in the control group (P <0.01). After treatment, the MMEF, FEF50, and FEF75 in the observation group were higher than those in the control group (P <0.05), while the levels of IL - 4, IL - 6, TNF - α, and CRP were lower than those in the control group(P < 0.01). There was no statistically significant difference in the incidence of adverse events between the observation group and the control group (P > 0.05).Conclusion: Shuhua Guwei Decoction combined with bacterial lysates in the treatment of children with RRTI and lung - spleen qi deficiency pattern can significantly improve clinical efficacy, TCM syndromes, pulmonary function, and immune function, while effectively reducing inflammatory levels, providing a new strategy for clinical treatment.

Objective: To analyze the effect of modified Banxia Xiexin Decoction in treating functional dyspepsia (FD).Methods: A total of 100 FD patients treated in the outpatient department of Jiangyin Traditional Chinese Medicine Hospital from January 2024 to December 2024 were retrospectively included as study subjects. The patients were randomly divided into a control group and an observation group, with 50 cases in each group. Case data were sourced from the hospital's electronic medical record system. The control group received conventional Western medicine treatment, while the observation group received conventional Western medicine combined with modified Banxia Xiexin Decoction. After 4 weeks of treatment, the efficacy of the two groups was compared. Before treatment, at week 1, and at week 4 of treatment, Traditional Chinese Medicine syndrome scores (epigastric fullness, reduced appetite, fatigue), gastric antrum contraction frequency, gastric antrum contraction amplitude, gastric half - emptying time, motilin, gastrin, and somatostatin (SS) were compared between the two groups. Adverse reactions in both groups were also recorded.Results: After 4 weeks of treatment, the total effective rate in the observation group was higher than that in the control group (P < 0.05) ; before treatment, at 1 week, and at 4 weeks of treatment, scores of traditional Chinese medicine (TCM) syndromes such as epigastric and abdominal fullness, reduced appetite, and fatigue, as well as antral contraction amplitude, gastric half - emptying time, and SS showed a gradual decreasing trend (P < 0.05), with the observation group lower than the control group (P <0.05). Antral contraction frequency, motilin, and gastrin showed a gradual increasing trend (P < 0.05), with the observation group higher than the control group. The main effects between groups were significant (P <0.05).Conclusion: modified Banxia Xiexin Decoction with significantly effective in treating functional dyspepsia (FD) can effectively improve patients' gastrointestinal motility and gastrointestinal hormone levels, and relieve clinical symptoms.