Objective: To explore the influence of Tongfei Pingxiao Decoction combined with acupoint acupuncture on TCM syndromes, serum immunoglobulin (Ig) E, intercellular adhesion molecule 1 (ICAM - 1) and interferon - γ (IFN - γ) in children with acute attack of bronchial asthma (BA).Methods: 144 children with BA acute attack of heat wheezing admitted to Jingzhou Hospital of Traditional Chinese Medicine Hospital were selected from October 2023 to October 2024 as the research subjects. According to the random number table method, the above children were divided into control group and observation group, 72 cases in each group. Both groups were given routine treatment, and the control group was treated with acupoint acupuncture, whereas the observation group was combined with Tongfei Pingxiao Decoction on the basis of the control group. The clinical efficacy and safety in the two groups were evaluated, and the differences in TCM syndromes scores, lung function [forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), peak expiratory flow (PEF)], serum IgE, ICAM - 1 and IFN - γ levels were analyzed in both groups.Results: The observation group had significantly higher total effective rate than the control group (P < 0.05). After treatment, the scores of wheezing, cough, runny nose, tongue and pulse and levels of serum IgE and ICAM - 1 in both groups were significantly decreased, and the above scores and levels in observation group were significantly lower than those in control group (P <0.05). The lung function indexes such as FVC, FEV1%, PEFR% and serum IFN- γ were significantly increased in the two groups after treatment, and the indexes were significantly higher in observation group (P < 0.05).Conclusion: Based on the conventional western medicine treatment, Tongfei Pingxiao Decoction combined with acupoint acupuncture can effectively improve the clinical symptoms and lung function of children with acute attack of BA. The role mechanism may be related to the regulations of serum IgE, IFN - γ and ICAM - 1.

Integrated Chinese - western medicine therapy  /  Acupuncture combined with medication  /  Bronchial asthma  /  Acute exacerbation stage  /  Tongfei Pingxiao Decoction