Objective: To investigate the differences in clinical blood indicators among infants with cytomegalovirus(CMV) hepatitis of different Traditional Chinese Medicine (TCM) syndromes, providing reference for clinical syndrome differentiation.Methods: A total of 120 infants meeting the diagnostic criteria for cytomegalovirus hepatitis were consecutively enrolled from Beijing Children's Hospital, Capital Medical University, from Febuary 2022 to Febuary 2024, including 40 cases each of dampness - heat internal accumulation syndrome, spleen deficiency with dampness retention syndrome, and qi stagnation with blood stasis syndrome. Differences in red blood cell parameters, platelet parameters, coagulation function, and liver function indicators were compared among the syndromes.Results: No significant differences were found in gender or age among the groups (P >0.05). The disease duration was longer in the spleen deficiency with dampness retention group and qi stagnation with blood stasis group compared to the dampness- heat internal accumulation group (P < 0.01). Regarding liver function, the qi stagnation with blood stasis group had higher GGT levels than the dampness - heat internal accumulation group (P <0.01), while the spleen deficiency with dampness retention group showed higher ALT levels (P <0.01). Both spleen deficiency with dampness retention and qi stagnation with blood stasis groups exhibited higher AST, TBIL, DBIL, and TBA levels than the dampness - heat internal accumulation group (P <0.05, P < 0.01). The qi stagnation with blood stasis group had higher TBIL, DBIL, and TBA levels than the spleen deficiency with dampness retention group (P <0.01). In red blood cell parameters, the spleen deficiency with dampness retention and qi stagnation with blood stasis groups showed lower RBC, HGB, and HCT but higher RDW compared to the dampness - heat internal accumulation group (P <0.05, P < 0.01). Platelet analysis revealed higher PLT in the qi stagnation with blood stasis group than in the spleen deficiency with dampness retention group (P <0.01). Coagulation tests demonstrated longer PT and higher INR in the qi stagnation with blood stasis group(P < 0.01) but lower FIB (P <0.05) versus the dampness - heat internal accumulation group. The spleen deficiency with dampness retention group had prolonged APTT (P < 0.05).Conclusion: Significant differences exist in blood indicators among different TCM syndromes of infantile cytomegalovirus hepatitis, providing a theoretical basis for clinical syndrome differentiation.

Cytomegalovirus hepatitis  /  TCM syndrome  /  Clinical indicators