Objective: To observe the clinical efficacy of oral Jianpi Shuyi Decoction in treating patients with chronic pancreatitis (CP) of liver depression and spleen deficiency syndrome.Methods: Using a randomized number table method, from September 2019 to July 2023 80 CP patients with liver depression and spleen deficiency syndrome who visited Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine were divided into a control group and an experimental group, with 40 cases in each group. The control group received Western medicine treatment, while the experimental group received the same plus Jianpi Shuyi Decoction. The treatment course was 4 weeks, and both groups were treated for 2 courses. The clinical efficacy, traditional Chinese medicine (TCM) symptom scores, abdominal pain visual analog scale (VAS) scores, laboratory indicators [serum amylase (AMS), lipase (LPS), fasting blood glucose (FBG)] levels, and the diameters of the main pancreatic duct and common bile duct were compared between the two groups.Results: After treatment, the total clinical effective rate in the experimental group was significantly higher than that in the control group (89.74% vs. 68.42%), with a statistically significant difference(P < 0.05). After treatment, abdominal pain, poor appetite, and pain - diarrhea symptoms in the control group were significantly reduced compared with those before treatment (P < 0.05). In the experimental group, abdominal pain, abdominal distension, poor appetite, depression and irritability, loose and sticky stools, and pain - diarrhea symptoms were significantly reduced compared with those before treatment (P < 0.05). Moreover, the scores for abdominal pain, abdominal distension, loose and sticky stools, and pain - diarrhea symptoms in the experimental group were significantly lower than those in the control group (P < 0.05). After treatment, the VAS scores of both groups were significantly reduced (P < 0.05), and the VAS score of the experimental group was significantly lower than that of the control group(P < 0.05). The AMS levels of both groups were significantly reduced (P < 0.05), and the experimental group was significantly lower than the control group (P < 0.05). No significant reduction in LPS level was observed in the control group (P > 0.05), while the LPS level in the experimental group was significantly reduced (P < 0.05) and significantly lower than that in the control group (P < 0.05). No significant reduction in FBG levels was observed in either group(P > 0.05), and there was no statistically significant difference between the two groups (P > 0.05). After treatment, the diameters of the main pancreatic duct and common bile duct in both groups showed no significant changes compared with those before treatment (P > 0.05).Conclusion: Jianpi Shuyi Decoction can effectively alleviate clinical symptoms such as abdominal pain, improve digestive function, reduce serum amylase and lipase levels, alleviate inflammatory responses, and demonstrate good safety in treating CP patients with liver depression and spleen deficiency syndrome.

Jianpi Shuyi Decoction  /  Chronic pancreatitis  /  Liver depression and spleen deficiency syndrome  /  Clinical efficacy  /  Safety