Objective: To explore the clinical effect of Shenghui Decoction on vascular dementia with kidney essence deficiency.Methods: A total of 110 VD patients with kidney essence deficiency syndrome admitted to the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from January 2023 to June 2024 were selected and divided into the control group and the observation group according to different clinical treatment methods, with 55 cases in each group. The control group was treated with conventional western medicine (nimodipine + piracetam), and the observation group was treated with western medicine combined with Shenhui decoction. The efficacy, TCM symptoms, cognitive function [Dementia Rating Scale (CDR), Mini - Mental State Examination (MMSE)], oxidative stress [nitrotyrosine(NT), reduced glutathione (GSH), total antioxidant capacity (T - AOC)], neurological function [neurofilament light chain polypeptide (NF - L), B - cell lymphoma - 2 (Bcl - 2), neuronal nitric oxide synthase (nNOS), brain- derived neurotrophic factor (BDNF)] and medication safety were compared between the two groups.Results: The efficacy of the observation group was higher than that of the control group (P < 0.05). After treatment, the TCM symptom scores, CDR scores, and levels of NT, NF - L and nNOS in the two groups were reduced, and the reduction was more significant in the observation group (P <0.05). After treatment, the MMSE score, GSH, T - AOC, Bcl - 2 and BDNF levels of the two groups increased, and the observation group increased more significantly (P <0.05). There was no significant difference in medication safety between the two groups (P > 0.05).Conclusion: Modified Shenghui Decoction is safe and effective in treating VD with kidney essence deficiency syndrome. It can not only promote the recovery of neurological function and reduce oxidative stress damage but also improve patients' cognitive function and enhance the overall clinical efficacy.

Vascular dementia  /  Modified Shenghui Decoction  /  Kidney essence deficiency syndrome  /  Cognitive function  /  Neurological function  /  Oxidative stress response