To investigate the effect of three different strains on the chemical composition of Polygonatum in the fermentation process of Polygonatum.

the crushed Rhizoma Polygonati was prepared into a suspension according to the 30 ∶ 70 ratio of care solution, and the three activated bacterial solutions of Lactobacillus casei, Lactobacillus rhamnosus and Bacillus subtilis were separately added according to the 5% inoculum. The sample morphology and the number of viable bacteria were observed. Ultra performance liquid chromatography quadrupole time-of-flight mass spectrometry (uplc-q-tof-ms) was used to analyze the differential chemical components of Polygonatum sibiricum before and after fermentation.

Rhizoma Polygonati was thickened after fermentation, with fluidity and sour taste. Milky white folds appeared after fermentation by Lactobacillus rhamnosus and Bacillus subtilis. On the 6th day of fermentation, Lactobacillus casei and Bacillus subtilis had the highest viable counts, which were 3.40 × 10⁸ CFU/g and 2.62 × 10⁹ CFU/g, respectively; The number of viable bacteria was the highest when Lactobacillus rhamnosus was fermented for 7 days, which was 2.59 × 10⁸ CFU/g; Three triterpenoid saponins, 2 flavonoids, 1 organic acid.

Lactobacillus rhamnosus and Lactobacillus casei can convert triterpenoid steroidal saponins into aglycones during the fermentation of Polygonatum sibiricum, and the utilization effect of saponins is better. Bacillus subtilis can convert flavonoid glycosides into aglycones, and the utilization effect of flavonoid glycosides is better.

To observe the effects of Rhubarb Decoction combined with intradermal granule on bone marrow edema, finger microcirculation and Th17/Treg in peripheral blood of rheumatoid arthritis.

A total of 100 patients with rheumatoid arthritis treated in the hospital from April 2022 to February 2024 were selected and divided into control group and observation group with 50 cases in each group by random number table method. Both groups were given basic symptomatic treatment, the control group was given granular intradermal acupuncture treatment on the basis of this treatment, and the observation group was given ultrasonic introduction therapy with rhubarb decoction on the basis of the control group. After 4 weeks of continuous treatment, the clinical efficacy of the control group and the observation group were compared. TCM syndrome score and wrist bone marrow edema score were observed before and after treatment, 6-point behavior score (BRS-6) and 28-point joint disease activity score (DAS-28) were performed. The vascular resistance index, vascular index, blood flow index and blood flow index of the middle nail bed artery of the patient were detected and calculated, and the levels of Th17/Treg, tumor necrosis factor-α (TNF-α), rheumatoid factor (RF) and reactive oxygen species (ROS) were detected.

The total effective rate of Rhubarb Decoction combined with intradermal acupuncture group was 98.00%, and that of Western medicine group was 82.00%. The total effective rate of Rhubarb Decoction combined with intradermal acupuncture group was higher than that of Western medicine group (P < 0.05). Joint pain, fever, joint swelling, morning stiffness, joint fever, sweating, poor joint flexion and extension, and thirst score of Rhubarb Decoction combined with intradermal acupuncture group were lower than those of Western medicine group (P < 0.05). DAS28, bone marrow edema and BRS-6 scores of Rhubarb Decoction combined with intradermal acupuncture group were lower than those of western medicine group (P < 0.05). The fingernail bed artery resistance index of Rhubarb Decoction combined with intradermal acupuncture group was lower than that of Western medicine group (P < 0.05), and the vascular index, blood flow index and blood flow index of Rhubarb Decoction combined with intradermal acupuncture group were higher than that of Western medicine group (P <0.05). The contents of Th17/Treg, TNF-α, RF and ROS in Rhubarb Decoction combined with intradermal acupuncture group were lower than those in western medicine group (P < 0.05).

Rhubarb Decoction combined with granular intradermal acupuncture can regulate Th17/Treg balance, inhibit inflammation and oxidative stress, reduce bone marrow edema, improve finger microcirculation, relieve pain and improve clinical efficacy in the treatment of patients with rheumatoid arthritis.

To analyze the effect of Modified Tongbi Formula combined with traditional Chinese medicine fumigation on rheumatoid arthritis (RA) syndrome of cold-dampness obstruction.

168 patients with RA cold-dampness obstruction syndrome admitted to the Eastern Theater General Hospital from April 2021 to June 2024 were divided into 2 groups according to different treatment methods. 83 patients in the control group were treated with traditional Chinese medicine fumigation, and 85 patients in the observation group were treated with Modified Tongbi Formula. The therapeutic effect of the two groups was compared.

The treatment effect of observation group was compared with control group (P <0.05). After treatment, TCM syndrome score, 28 joint activity score (DAS28) and clinical disease activity index (CDAI) in observation group were lower than those in control group (P < 0.05). After treatment, the levels of rheumatoid factor (RF), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), D-dimer (D-D) and immunoglobulin (IgG, IgA, IgM) in observation group were lower than those in control group (P < 0.05). The incidence of adverse reactions was compared between observation group and control group (P >0.05).

Modified Tongbi Formula combined with traditional Chinese medicine fumigation has a remarkable effect, which can significantly reduce the score of traditional Chinese medicine symptoms, significantly reduce the level of inflammation, enhance immune function, reduce disease activity, and do not increase adverse drug reactions.

To investigate the efficacy and safety of Xiegan Zhitong Decoction combined with famciclovir tablets and mecobalamin tablets in treating herpes zoster with liver channel stagnation-heat syndrome.

92 patients diagnosed with herpes zoster with liver channel stagnation-heat syndrome in the Department of Dermatology of Third Affiliated Hospital of Beijing University of Chinese Medicine from June 2022 to June 2024 were included. All patients received oral Xiegan Zhitong Decoction (1 dose/day, decocted in water) for one week as one treatment course, combined with famciclovir tablets for antiviral treatment and mecobalamin tablets for nerve nutrition. Clinical efficacy at different treatment courses, time-effect scores (time to stop blistering, crust formation time, crust shedding time, and pain relief time), pain and sleep scores, incidence of postherpetic neuralgia, and TCM syndrome scores were evaluated.

After treatment at each course, significant improvements were observed in time-effect scores, sleep and pain scores, and TCM syndrome scores (P <0.01, P < 0.001). The cumulative effective rates at 1, 2, 3, and 4 weeks were 27.17% (25/92), 88.04% (81/92), 94.57% (87/92), and 98.91% (91/92) respectively. The incidence of postherpetic neuralgia was 1.09% (1/92).

Xiegan Zhitong Decoction combined with famciclovir and mecobalamin tablets shows significant efficacy in treating herpes zoster with liver channel stagnation-heat syndrome, shortening recovery time, improving sleep, reducing pain, ameliorating TCM syndromes, with low incidence of postherpetic neuralgia and few adverse reactions.

To evaluate the efficacy of celecoxib combined with Danggui Niantong Decoction in the treatment of cervical spondylotic radiculopathy Wind-Damp-Heat Obstruction syndrome).

A total of 98 patients with cervical radiculopathy (Wind-Damp-Heat Obstruction syndrome) admitted to the orthopedics and inpatient department of Huanggang Central Hospital from January 2023 to December 2023 were selected as the study objects, and were divided into 2 groups according to random number table method, with 49 cases each. The control group was treated with celecxib on the basis of cervical traction therapy, and the experimental group was treated with Danggui Niantong Decoction on the basis of control group for 4 weeks. The clinical efficacy, TCM symptom score, VAS scale score, NDI questionnaire, CASCS scale score, serum inflammatory indicators IL-1β, IL-6β, TNF-αlevel and incidence of adverse reactions were compared between the two groups.

The total effective rate of experimental group after treatment was significantly higher than that of control group (P < 0.05). After treatment, TCM symptom score of two groups was significantly decreased, and the test group was lower than the control group(P < 0.05). VAS and NDI scores after treatment were lower than before treatment, CASCS scores were higher than before treatment, and the change range of experimental group was higher than that of control group (P <0.05). The serum levels of IL-1β, IL-6β and TNF-αin 2 groups after treatment were lower than before treatment, and the experimental group was lower than the control group(P < 0.05).

Danggui Niantong Decoction combined with celecxib has a good effect in the treatment of cervical spondylopathy patients with rheumatic heat arthralgia nerve root type, which can significantly improve cervical spine function and clinical symptoms, reduce the level of pain and inflammatory factors, and is safe, worthy of clinical promotion.

To investigate epidemiological trends in pulmonary nodule detection, characterize the distribution patterns of nodule size, morphology, anatomical location, and multiplicity, analyze gender- and age-related correlations, and propose Traditional Chinese Medicine (TCM)-based intervention strategies.

A retrospective cohort analysis was conducted using low-dose computed tomography (LDCT) data from 5 426 individuals undergoing routine health screenings at Liaocheng Hospital of Traditional Chinese Medicine from January to December 2024, identifying 4 076 patients with pulmonary nodules. Statistical analyses, including chi-square tests and Fisher's exact tests, were performed using SPSS 23.0.

Pulmonary nodule detection rates demonstrated a progressive increase in recent years, peaking in 2022, followed by stabilization in 2024. Nodule characteristics revealed a predominance of solid nodules (70.6%), micro-nodules (< 10 mm, 73.3%), and multiple nodules (84.3%). Anatomically, the right upper lobe exhibited the highest nodule prevalence (20.8%). Gender-specific analysis identified significant disparities: females displayed a higher proportion of multiple nodules (P < 0.05) and ground-glass opacity (GGO) nodules (33.7% vs. 23.0% in males), whereas males exhibited a greater prevalence of solid nodules (75.5% vs. 64.7%). Age-stratified comparisons indicated markedly higher detection rates in middle-aged and elderly cohorts (≥40 years) versus younger groups (P <0.05), with larger nodules (≥10 mm) more frequent in older populations (3.0% vs. 0.8%). Notably, part-solid nodules constituted the predominant subtype among larger lesions (27.3%). TCM Constitution distribution showed that the top four biased constitutions were phlegm dampness constitution (19.9%), qi stagnation constitution (15.0%), Qi deficiency constitution (12.0%), and blood stasis constitution (10.0%).

Gender and age significantly influence pulmonary nodule characteristics, with part-solid morphology being disproportionately associated with larger nodules, underscoring the necessity for enhanced malignancy risk stratification in such cases. The centralized distribution of TCM Constitution further confirms the core pathogenesis of qi stagnation and phlegm coagulation. This study establishes foundational epidemiological data for pulmonary nodule management in asymptomatic populations and integrates TCM theoretical frameworks into clinical strategies. However, longitudinal follow-up and comprehensive adjustment for confounders are required to validate these findings and optimize therapeutic approaches.

To explore the influence of combination of Formula No.2 for Heart Failure and acupoint application on myocardial enzymes and serum N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and cardiac troponin T (cTnT) in patients with chronic heart failure (CHF).

Totally 120 patients with chronic heart failure were randomized in the Taizhou hospital from Dec. 2021 to December Dec. 2024 were randomly grouped. 60 cases in the control group were treated with conventional western medicine, and the remaining 60 cases in the treatment group were given combined therapy with Formula No.2 for heart failure and acupoint application on this basis. The clinical efficacy and TCM symptoms scores and levels of serum myocardial enzymes [lactate dehydrogenase (LDH), creatine kinase (CK), CK-MB, AST], NT-pro-BNP and cTnT before and after treatment were compared between groups, and the adverse reactions in both groups were observed.

The treatment group had higher total effective rate of treatment and lower scores of TCM symptoms after treatment compared to the control group (P < 0.05). The levels of LDH, CK, CK-MB, AST, NT-pro-BNP and cTnT in the treatment group were reduced after treatment compared with those in the control group (P < 0.05). No obvious differences were exhibited in the adverse reactions between both groups (P >0.05).

Formula No.2 for heart failure combined with acupoint application has a significant effect in the treatment of CHF, and it can effectively relieve the symptoms, and improve the myocardial enzymes and serum NT-pro-BNP and cTnT, without causing obvious adverse reactions.