To explore the clinical effect of combination of Dachaihu Decoction and amlodipine besylate in treating hypertension with liver-fire hyperactivity syndrome.

A total of 148 hypertensive patients with liver-fire hyperactivity syndrome admitted to Pingyi County Traditional Chinese Medicine Hospital between January 2022 and January 2025 were divided into control group (n = 74, amlodipine besylate) and combined group (n = 74, Dachaihu Decoction combined with amlodipine besylate) according to the random number table method. The clinical efficacy, TCM symptoms scores and 24 h ambulatory blood pressure were compared between both groups, and the safety and quality of life in the two groups were evaluated.

Compared with the control group, the clinical efficacy in the combined group was enhanced after treatment (P < 0. 05) while the scores of TCM syndromes were reduced (P <0.05). The 24 h average systolic, 24 h average diastolic blood pressures, daytime average systolic blood pressure, daytime average diastolic blood pressure, nighttime average systolic blood pressure and nighttime average diastolic blood pressure in the combined group after treatment were decreased compared with those in the control group (P < 0.05). The scores of various dimensions of quality of life brief scale were increased in the combined group after treatment (P <0.05). No significant difference was exhibited in the occurrence of adverse reactions between groups (P > 0.05).

Dachaihu Decoction combined with amlodipine besylate has significant efficacy in the treatment of hypertensive patients with liver-fire hyperactivity syndrome, and it can effectively reduce blood pressure, improve symptoms, and enhance the quality of life, with guaranteed safety.

To investigate the efficacy of Buyang Huanwu Decoction combined with "Shao's Five-Needle Technique" in treating unstable angina pectoris (UA) of coronary heart disease.

Using a random number table method, 120 patients with UA of coronary heart disease admitted to Baoji Hospital of Traditional Chinese Medicine from January 2023 to July 2024 were divided into a decoction group, an acupuncture group, and a combination group, with 40 cases in each group. All three groups received conventional treatment. Additionally, the decoction group was treated with Buyang Huanwu Decoction, the acupuncture group was treated with "Shao's Five-Needle Technique," and the combination group was treated with Buyang Huanwu Decoction combined with "Shao's Five-Needle Technique." One treatment course consisted of 10 days, and all groups were treated for 2 courses. The clinical efficacy of angina pectoris, electrocardiogram efficacy, and adverse reactions were compared among the three groups. TCM syndrome scores, clinical symptoms, cardiac function, blood lipids, and serum inflammatory indicators were recorded before and after treatment in each group.

The overall comparison of the total clinical effective rates and total electrocardiogram effective rates among the three groups showed statistically significant differences (P <0.05). After treatment, the total TCM syndrome scores, clinical symptom-related indicators of angina pectoris, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and serum levels of interleukin (IL)-6, IL-1β, high-sensitivity C-reactive protein (hs-CRP), and tumor necrosis factor-α(TNF-α) decreased in all three groups compared with those before treatment (P < 0.05). The combination group had lower total TCM syndrome scores, clinical symptoms of angina pectoris, TC, LDL-C, and serum inflammatory-related indicators than the decoction group and acupuncture group (P <0.05). After treatment, the cardiac ejection fraction (EF), stroke volume (SV), and high-density lipoprotein cholesterol (HDL-C) increased in all three groups compared with those before treatment (P < 0.05). The combination group had higher EF and SV than the decoction group and acupuncture group (P <0.05). There were no statistically significant differences in any indicators between the decoction group and the acupuncture group (P > 0.05). The comparison of the total incidence of adverse reactions among the three groups showed no statistically significant difference (P > 0.05).

Buyang Huanwu Decoction combined with "Shao's Five-Needle Technique" is safe and effective in treating UA of coronary heart disease. It significantly improves angina symptoms and cardiac function, with notable lipid-regulating and anti-inflammatory effects.

To explore the effect of Hushen Jiangtang paste in non dialysis diabetes nephropathy patients with spleen kidney yang deficiency.

Totally 93 patients with non dialysis diabetes nephropathy were selected from the department of nephrology and rheumatology and the department of diabetes in Zhengzhou Hospital of Traditional Chinese Medicine from April 2023 to January 2025. They were divided into the granule group (n = 46) and the paste group (n=47) by lot drawing. During the research process, a total of 3 cases withdrew or were lost to follow-up. Among them, one case in the particle group withdrew due to unwillingness to continue cooperating with treatment; One case was lost to follow-up in the paste group, and one case automatically withdrew. Finally, there were 45 cases in the granule group and 45 cases in the paste group. The granule group was given Urinary Detoxification Granules (sugar free type) orally, while the ointment group was given Hushen Jiangtang paste orally. Compare the clinical efficacy, TCM syndrome score, glucose and lipid metabolism, proteinuria, renal function, meridian characteristics, and adverse reactions between two groups.

The total clinical effective rate of the ointment group was 91.11% (41/45), which was higher than that of the granule group 75.56% (34/45) (P < 0.05). After 24 weeks of treatment, the two groups showed a decrease in overall swelling, pale complexion, cold limbs, cold and painful waist and spine, and mental fatigue scores compared to before treatment(P < 0.05). The plaster group was lower than the granule group (P < 0.05). After 24 weeks of treatment, the levels of TC, TG, LDL-C, FBG, and HbA1c in both groups decreased compared to before treatment(P < 0.05), and the paste group was lower than the granule group (P <0.05). There was no significant difference in Scr levels between the particle group before treatment and 24 weeks after treatment (P > 0.05) ; The Scr level in the ointment group decreased after 24 weeks of treatment compared to before treatment (P < 0.05) ; After 24 weeks of treatment, the Scr level in the ointment group was lower than that in the granule group (P < 0.05) ; After 24 weeks of treatment, the levels of mAlb, 24-hour urine protein quantification(24h UTP), and BUN in both groups decreased compared to before treatment(P < 0.05), and the paste group was lower than the granule group (P <0.05). After 24 weeks of treatment, the physical fitness and Yin/Yang meridian energy index levels of the two groups increased compared to before treatment(P < 0.05), with the ointment group higher than the granule group (P < 0.05); The energy index levels of the upper/lower, autonomic nervous system (P < 0.05), and left/right meridians decreased compared to before treatment(P < 0.05), and the ointment group was lower than the granule group (P < 0.05). According to Fisher's exact probability test, there was no significant difference in the incidence of adverse reactions between the paste group (2.22%, 1/45) and the granule group (6.67%, 3/45) (P >0.05).

Hushen Jiangtang paste can regulate glucose and lipid metabolism, proteinuria, and renal function in non dialysis diabetes nephropathy patients with spleen and kidney yang deficiency, improve the characteristics of meridians, regulate TCM syndrome scores, and has good safety and improve clinical efficacy.

To investigate the clinical efficacy of Jiedu Yizhi Formula for Alzheimer's disease (AD) based on the theory of "marrow deficiency and toxin damage. "

A total of 88 AD patients admitted to Shanghai Pudong Hospital from June 2024 to March 2025 were enrolled and randomly divided into an observation group (conventional treatment + Jiedu Yizhi Formula) and a control group (conventional treatment), with 44 cases in each group. The therapeutic efficacy was compared between the two groups after 12 weeks of treatment. Cognitive function [Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA)], activities of daily living [Activity of Daily Living Scale (ADL), Barthel Index], cerebral microcirculation (vertebrobasilar artery blood flow velocity), oxidative stress indicators [superoxide dismutase (SOD), malondialdehyde (MDA), β-amyloid (Aβ)], and inflammatory indicators [interleukin (IL)-1β, IL-6, tumor necrosis factor-alpha (TNF-α)] were assessed before treatment and after 12 weeks of treatment.

After 12 weeks of treatment, the total effective rate in the observation group was higher than that in the control group (P <0.05). After 12 weeks of treatment, the MMSE, MoCA, Barthel Index scores, cerebral microcirculation indicators (left vertebral artery, right vertebral artery, basilar artery), and SOD levels in the observation group were increased compared with before treatment (P < 0.05) and were higher than those in the control group (P < 0.05). The ADL score, MDA, Aβ, IL-1β, and TNF-α levels in the observation group were decreased compared with before treatment (P < 0.05) and were lower than those in the control group (P < 0.05). There was no significant difference in IL-6 levels between the two groups before treatment and after 12 weeks of treatment (P > 0.05).

Jiedu Yizhi Formula demonstrates good clinical efficacy in treating Alzheimer's disease, significantly improving cognitive function and activities of daily living. The mechanism may be related to improving cerebral microcirculation and reducing oxidative stress and inflammation levels.

To investigate the effects of Gegen Decoction combined with probiotics on symptom scores, time to negative conversion of fecal reducing substances, fecal pH value, and microbiome-related indicators in pediatric acute diarrhea.

A total of 98 children with acute diarrhea treated at Qinhuangdao Hospital of Traditional Chinese Medicine from January 2024 to July 2024 were randomly divided into an experimental group (Gegen Decoction Granules + probiotics) and a control group (probiotics alone), with 49 cases in each group. During follow-up, 3 cases dropped out in the experimental group and 2 cases in the control group, resulting in 46 cases in the experimental group and 47 cases in the control group completing the study. Both groups received oral rehydration and dietary management according to clinical guidelines. The treatment duration was 5 days. Traditional Chinese medicine (TCM) syndrome scores, time to negative conversion of fecal reducing substances, fecal pH value, number of bowel movements within 24 hours, fecal calprotectin, short-chain fatty acids (SCFAs), and fecal secretory immunoglobulin A (sIgA) levels were compared between the two groups before and after treatment. Adverse events were also recorded.

The experimental group showed significantly greater improvements than the control group in terms of symptom score reduction, time to negative conversion of fecal reducing substances, restoration of fecal pH value, increase in total SCFAs, butyrate proportion, and fecal sIgA, as well as reduction in fecal calprotectin (P < 0.05, P < 0.01). The overall response rate was 93.48% (43/46) in the experimental group and 80.85% (38/47) in the control group (P <0.05). There was no significant difference in the incidence of adverse events between the two groups (P > 0.05).

Gegen Decoction combined with probiotics can significantly alleviate symptoms of acute diarrhea in children, promote recovery of carbohydrate absorption, correct the acidic intestinal environment, and modulate microbiome and mucosal immunity indicators, with a favorable safety profile. It represents an effective integrated treatment strategy.

To investigate the difference of expression levels of IL-4 and IL-18 in the brain tissue of insomnia model rats with 'kidney failing to store willpower' Treated with the Processed Polygala tenuifolia.

A total of 40 male SD rats were randomly divided into normal group, model group, Esazolam group, Processed Polygala tenuifolia low-dose group and Processed Polygala tenuifolia high-dose group with 8 rats in each group. D-galactose (D-gal) combined with p-chlorophenylalanine (PCPA) was used to prepare the rats with 'kidney failing to store willpower'. After successful modeling, the western medicine group was given Esazolam 0.2mg/kg/d by gavage, and the low dose Chinese medicine group was given Processed Polygala tenuifolia 2.1g/kg/d by gavage, the high dose group was given 4.2g/kg/d gavage, and the normal group and model group were given equal volume normal saline gavage for 7 days. Morris water maze test was used to evaluate the learning and memory ability of rats. HE and Nissl staining were used to observe the cell morphology and structure of rat brain. The expression levels of IL-4 and IL-18 in rat brain were detected by IHC and Western blot.

Compared with normal group, incubation period and total motor distance of rats in model group were significantly increased (P <0.01), the percentage of exploration time in the target quadrant was significantly reduced (P <0.01). The neuronal nucleus was dislocated, the nucleolus was enlarged, the inflammatory cells were infiltrated, and the number of nissl was significantly decreased (P < 0.01). The intercellular spaces of neuron cells are widened, and the synaptic structure is incomplete, and the expression level of IL-4 was significantly decreased (P <0.01), the expression level of IL-18 was significantly increased (P < 0.01). Compared with model group, latency and total distance of movement of rats in low dose group and high dose group were significantly decreased (P < 0.01), the percentage of exploration time in the target quadrant significantly increased (P < 0.01). The neuronal damage and inflammatory cell infiltration were alleviated to varying degrees, and the number of nissl was increased to varying degrees (P < 0.01). The morphology and structure of neuronal nucleosomes were improved to varying degrees, and the expression level of IL-4 was significantly increased (P < 0.01), the expression level of IL-18 was significantly decreased (P <0.01).

The Processed Polygala tenuifolia can significantly improve the sleep, learning and memory ability of insomnia model rats with 'kidney failing to store willpower', and alleviate the inflammatory damage state of the neurons in rats with 'kidney failing to store willpower'. The mechanism of improving the sleep of the rats with insomnia model rats with 'kidney failing to store willpower' may be related to the increase of IL-4 and the decrease of IL-18 expression level in the brain tissue.

To explore the pharmacodynamic effects of Buxu Xiaoke Mixture combined with pyrroloquinoline quinone (PQQ) on type 2 diabetes mellitus (T2DM) rats and analyze its possible mechanism of action.

A T2DM rat model was established. Rats in the positive group, 1/4 Buxu Xiaoke Mixture + PQQ group, 1/2 Buxu Xiaoke Mixture + PQQ group, full-dose Buxu Xiaoke Mixture + PQQ group, Buxu Xiaoke Mixture group, and PQQ group were administered for 12 weeks. Blood glucose, urine volume, body weight, food intake, and water intake of rats were detected. ELISA was used to detect blood glucose, blood lipids, oxidative stress, and inflammatory factor-related indicators in rat serum, while HE staining was applied to observe pathological changes in kidney and pancreas tissues.

In the full-dose Buxu Xiaoke Mixture + PQQ group, the FINS level was increased (P <0.01), the HOMA-β level was increased (P < 0.05), the GSP and HOMA-IR levels were decreased (P < 0.01), the TG, TC and LDL-C levels were decreased (P < 0.01), the HDL-C level was increased (P < 0.01), the MDA level was decreased (P <0.01), the SOD and GSH-Px levels were increased (P <0.01), and the IL-1and TNF-α levels were decreased (P <0.01). This treatment could significantly improve glucose and lipid metabolism, inflammation and oxidative stress in rats, alleviate kidney and pancreatic tissue damage, with a better efficacy than monotherapy and a dose-dependent effect. Analysis showed that the mechanism of action may involve pathways related to inflammation and oxidative stress in T2DM.

The combination of full-dose Buxu Xiaoke Mixture and PQQ can synergistically improve T2DM via multi-targets by increasing GSP and decreasing MDA, TG levels, and the mechanism of action may be related to inhibiting oxidative stress and inflammatory response.