To explore the effect of Hushen Jiangtang paste in non dialysis diabetes nephropathy patients with spleen kidney yang deficiency.

Totally 93 patients with non dialysis diabetes nephropathy were selected from the department of nephrology and rheumatology and the department of diabetes in Zhengzhou Hospital of Traditional Chinese Medicine from April 2023 to January 2025. They were divided into the granule group (n = 46) and the paste group (n=47) by lot drawing. During the research process, a total of 3 cases withdrew or were lost to follow-up. Among them, one case in the particle group withdrew due to unwillingness to continue cooperating with treatment; One case was lost to follow-up in the paste group, and one case automatically withdrew. Finally, there were 45 cases in the granule group and 45 cases in the paste group. The granule group was given Urinary Detoxification Granules (sugar free type) orally, while the ointment group was given Hushen Jiangtang paste orally. Compare the clinical efficacy, TCM syndrome score, glucose and lipid metabolism, proteinuria, renal function, meridian characteristics, and adverse reactions between two groups.

The total clinical effective rate of the ointment group was 91.11% (41/45), which was higher than that of the granule group 75.56% (34/45) (P < 0.05). After 24 weeks of treatment, the two groups showed a decrease in overall swelling, pale complexion, cold limbs, cold and painful waist and spine, and mental fatigue scores compared to before treatment(P < 0.05). The plaster group was lower than the granule group (P < 0.05). After 24 weeks of treatment, the levels of TC, TG, LDL-C, FBG, and HbA1c in both groups decreased compared to before treatment(P < 0.05), and the paste group was lower than the granule group (P <0.05). There was no significant difference in Scr levels between the particle group before treatment and 24 weeks after treatment (P > 0.05) ; The Scr level in the ointment group decreased after 24 weeks of treatment compared to before treatment (P < 0.05) ; After 24 weeks of treatment, the Scr level in the ointment group was lower than that in the granule group (P < 0.05) ; After 24 weeks of treatment, the levels of mAlb, 24-hour urine protein quantification(24h UTP), and BUN in both groups decreased compared to before treatment(P < 0.05), and the paste group was lower than the granule group (P <0.05). After 24 weeks of treatment, the physical fitness and Yin/Yang meridian energy index levels of the two groups increased compared to before treatment(P < 0.05), with the ointment group higher than the granule group (P < 0.05); The energy index levels of the upper/lower, autonomic nervous system (P < 0.05), and left/right meridians decreased compared to before treatment(P < 0.05), and the ointment group was lower than the granule group (P < 0.05). According to Fisher's exact probability test, there was no significant difference in the incidence of adverse reactions between the paste group (2.22%, 1/45) and the granule group (6.67%, 3/45) (P >0.05).

Hushen Jiangtang paste can regulate glucose and lipid metabolism, proteinuria, and renal function in non dialysis diabetes nephropathy patients with spleen and kidney yang deficiency, improve the characteristics of meridians, regulate TCM syndrome scores, and has good safety and improve clinical efficacy.