This study innovatively developed an intelligentmodel of syndrome differentiation and machine learning trainingmethod with zero-clinical samples which could intuitively infer with diagnostic knowledge of traditional Chinesemedicine，and conducted case analysis on the syndrome differentiation of vertigo.

Based on the deep learningmodel Bert，a new inference algorithm was proposed to establish a new intelligent inferencemodel of TCM diagnosis. According to the key points of six types of dizziness syndrome differentiation（such as liver Yang hyperactivity and Qi-blood deficiency）in Internal Medicine of TCM，a random function was used to generate 400 samples of sentence sequences for each syndrome differentiation class，to let the model learn diagnostic knowledge directly. In order to compare the prediction performance of the newmodeland the random forest model，it used the 5-fold crossovermethod to evaluate themodel for all syndrome differentiation classes with indicators such as Accuracy，F1 score，ROC curve，P-R curve，etc. Furthermore，the reasoning diagrams outputted by the newmodelwere showed to demonstrate the algorithm reasoning process of simulations of TCM syndrome differentiation thinking. Based on the generated combination data of the symptoms and probabilities during the model reasoning process，the probability density distribution map of syndrome types，the correlation clustering heatmap of symptom types and the Pearson correlation analysismap of syndrome types were calculated and drawn to further verify the reliability of the syndrome differentiation results.

The average accuracies and F1 scores of the new model tested with the 5-fold crossmethod were 0.990 and 0.971，respectively. In all the syndrome types，the accuracy（0.975）and F1 score（0.923）of liver-kidney Yin deficiency were the lowest. The ROC curve and P-R curve showed that the newmodel had a little poor ability of prediction for liver-kidney Yin deficiency and liver Yang hyperactivity，while the random forestmodel had a little poor ability of prediction for Qi-blood deficiency syndrome. The data distribution of the probability density distributionmap and the correlation clustering heatmap were consistentwith the inference conclusion of the new model. The Pearson correlation map showed that the syndrome type diagnosed with the new model was negatively correlated with other syndrome types，and the P-value of the correlation coefficientwas less than 0.01，indicating that the newmodel had a good discrimination.

It can intelligently diagnose and demonstrate the reasoning process of dizziness based on the new intelligent diagnostic reasoningmodel，whichmay help to solve the bottleneck problems in the current field of artificial intelligence diagnosis in traditional Chinesemedicine.

To study the effectof Ganfei Bingzhi Formula（肝肺并治方）on gutmicrobiota of ratswith ulcerative colitis.

Thirty SD ratswere randomly divided into Ganfei Bingzhi Formula high dose group（A），Ganfei Bingzhi Formulamedium dose group（B），Ganfei Bingzhi Formula low dose group（C），model group（D）and blank group（E），with 6 rats in each group. A ratmodel of UC was established by using trinitrobenzenesulfonic acid solution（TNBS）/ethanol method. After gavage with different intervention factors，the intestinal contents of rats were taken out and the bacterial population was sequenced using 16S rRNA method.

The dominant bacteria in the intestinal contents of rats in each group were Firmicutes and Bacteroidetes. Aftermodeling，the number of Firmicutes decreased，while the number of Bacteroidetes increased. Intervention with Ganfei Bingzhi Formula can increase the number of Firmicutes and reduce the number of Bacteroidetes. The effectof themedium dose group was themost significant. The sparse curve ofα-diversity tended to flatten out as the sequencing depth increased. The difference between themedium dose group and the blank group in the PCoA analysis chartand the distancematrix ofβ-diversity were the smallest. The composition of intestinal contents in themiddle dose group was themost similar to that of the blank group in phylum level，species level and genus level. There was a significant difference in the phylum of actinomycetes among the groups.

Ganfei Bingzhi Formula can correct the distribution of intestinalmicrobiota in rats with UC，making it tend to the normal gutmicrobiota. Among them，the effect of themedium dose group ismost obvious.

To investigate whether Xuguan Ruanhua Pill（血管软化丸）can improve atherosclerosis in APOE-/-mice by regulating the AMP-activated protein kinase（AMPK）/NOD-like receptor thermal protein domain associated protein 3（NLRP3）pathway and inhibiting cellular death.

Ten C57BL/6Jmicewere used as blank control group. Sixty apolipoprotein E knockout（APOE-/-）micewere random ly divided intomodel group，Xuguan Ruanhua Pill low-dose group，Xuguan Ruanhua Pill high-dose group，atorvastatin group，Xuguan Ruanhua Pill high dose＋AMPK inhibitor combination group and AMPK inhibitor group，and were given high-fatdiet to constructatherosclerosis（AS）mousemodel for18 weeks and were given different methods of intervention in the 13th week. Differentmethods of intervention were given，and the sampleswere taken 6 weeks after the intervention，and the levels of triglyceride（TG），total cholesterol（TC），low density lipoprotein-eholesterol（LDL-C）and high density lipoprotein-eholesterol（HDL-C）were detected respectively in each group. The pathological and morphological changes ofmouse aortic tissues were observed by HE and Oil Red O staining. The levels of interleukin（IL）-1βand IL-18 in aortic tissueswere determined by ELISA，and the protein expressions of AMPK，P-AMPK，NLRP3，Cleaved-Caspase1 and GSDMD-N were detected byWestern Blot. The P-AMPK and NLRP3 protein distribution in the aortic rootwas detected by immunofluorescencemethod and transmission electron microscopy was used for the observation of aortic endothelial ultrastructural changes.

Compared with those in the control group，themodel group had significantly higher serum levels of TG，TC and LDL-C，significantly lower HDL-C levels（P<0.01），disorganised cellarrangement in the aortic rootand obvious fat vacuoles，significant atheromatous plaque deposition in the aorta，significantly lower levels of P-AMPK protein expression，and significantly lower levels of NLRP3，Cleaved-Caspase 1 and GSDMD-N proteinswere significantly increased（P<0.05 or P<0.01）. Compared with those of themodel group，the lipid disorderswere improved in the high and low dose groups of Xuguan Ruanhua Pill and the atorvastatin group，and the degree of aortic tissue and cytopathic lesions were reduced，with a significant increase in the expression level of P-AMPK，and a significant decrease in the expression levels of NLRP3，Cleaved-Caspase 1 and GSDMDN proteins（P<0.05 or P<0.01）. The expression levels were significantly reduced（P<0.05 or P<0.01），and the levels of IL-1βand IL-18 were significantly reduced（P<0.05 or P<0.01）. Compared with those of the Xuguan Ruanhua Pill high dose＋AMPK inhibitor group，the level of coagulopathy-associated proteins in the Xuguan Ruanhua Pill high-dose group was significantly reduced（P<0.05 or P<0.01），and the degree of damage to aortic endothelial cells was attenuated，while that in the AMPK inhibitor group in contrast.

Xuguan Ruanhua Pillmay exert a protective effect on atherosclerotic mice by regulating the AMPK/NLRP3 pathway to reduce cell death.

To study the effectof early electroacupuncture therapy on the recovery of nerve function after craniocerebral injury.

A total of270 patients diagnosed as craniocerebral injury were divided into two groups according to the random number table，135 patients in the control group received conventional Western medicine treatment，and 135 patients in the study group received electroacupuncture treatment based on the control group. The clinical efficacy，lower limb function，neurological function defect and walking ability of the two groupswere observed and compared.

The total effective rate of the study group was 97.78%（132/135），higher than that（73.33%，99/135）of the control group，and the difference was statistically significant（P<0.05）. After treatment，compared with thatof the control group，the TCM syndrome score of the study group was lower，and the difference was statistically significant（P<0.05）. Compared with those of the control group，the National Institute of Health Stroke Scale（NIHSS）score，Fugl-Meyer score，Berg score and Barthel index in the study group were higher，and the differences were statistically significant（P<0.05）. Compared with those of the control group，the levels of VILIP-1，NSE and S100βin the study group were lower，and the difference was statistically significant（P<0.05）.

Electroacupuncture can improve themotor function and nerve function of patients with craniocerebral injury and promote the recovery of patients as soon as possibly，which has high clinical application value.

To analyze the effect of Huaiqihuang Granule（槐杞黄颗粒）combined with Xiaoqinglong Decoction（小青龙汤）on immune function and prognosis of children with Qideficiency of lung and spleen syndrome in remission stage of asthma.

One hundred and six children with asthmawith deficiency of lung and spleen in remission stage admitted to the hospital from January 2021 to June 2022 were random ly divided into the combined group（53 cases）and the control group（53 cases）. Both groupswere given long-term asthma control drugs and Huaiqihuang Granule and the combined group added Xiaoqinglong Decoction for onemonth. The changes of humoral immunity，inflammatory factors，lung function，Chinese version of children asthma control questionnaire（Ch-CACT），TCM syndrome score and other indicators before and after treatmentwere compared between the two groups，and the clinical efficacy of the two groupswas compared.

After onemonth of treatment，the levels of immunoglobulin A（IgA），immunoglobulin G（IgG）and immunoglobulin M（IgM）in both groupswere higher than those before treatment，while immunoglobulin E（IgE）was lower than that before treatment. After onemonth＇s treatment，the levels of IgA，IgG and IgM in the combined group were higher than those in the control group，and the IgE was lower than that in the control group（P<0.05）. After onemonth of treatment，the levels of interferon-γ（IFN-γ）increased and the level sof eosinophil（EOS）and interleukin-4（IL-4）decreased in both groups. The level of IFN-γin the combined group was higher than that in the control group，and the levels of EOS and IL-4 were lower than those in the control group（P<0.05）. The values of forced expiratory volume in one second（FEV1%）and peak expiratory flow（PEF）in both groups increased after onemonth of treatment. And the values of FEV1% and PEF in the combined group were higher than those in the control group（P<0.05）. After onemonth of treatment，the Ch-CACT scores of the two groupswere higher than those before treatment，and the TCM syndrome scoreswere lower than those before treatment. The Ch-CACT score of the combined group was higher than that of the control group，and the TCM syndrome scorewas lower than thatof the control group（P<0.05）. After onemonth of treatment，the total effective rate of the combined group was 88.68%（47/53），which was higher than that of the control group（71.70%，38/53）（P<0.05）.

On the basis of routine westernmedicine treatment of Huaiqihuang Granule，Modified Xiaoqinglong Decoction is helpful to improve the immune function，inflammatory factors and lung function of children with asthmawith Qideficiency of lung and spleen in remission stage，thus alleviating clinical symptoms，improving clinical efficacy and the quality of prognosis of children.