To observe the curative effect of benefiting vital Qi and nourishing heart method（back Shu-acupoint warm acupuncture）on the degenerative degeneration of knee joint with insufficient kidney Yang.

A total of 80 patients with knee degenerative degeneration with insufficient kidney Yang（admitted from May 2021 to December 2022）were included in the study and divided into control group（40 cases）and observation group（40 cases）by random number table method.The patients in the control group received knee replacement treatment.The observation group was treated with benefiting vital Qi and nourishing heart method（back Shu-acupoint warm acupuncture）on the basis of control group.The data of each group was observed，including the rate of excellent and good curative effects，the TCM symptom scores before and after treatment，the pain score of patients 3 d，6 d and 9 d（visual analogue scale，VAS），and the levels of C-reactive protein（CRP），tumor necrosis factor-α（TNF-α）and interleukin-6（IL-6），Lysholm knee scale scores before and after treatment，the incidence of complications and the the MOS item short from health survey（SF-36）before treatment，2 and 4 weeks of treatment health survey.

The rate of excellent and good treatment effect in the observation group（95.00%，38/40）was higher than that in the control group（80.00%，32/40）（P<0.05）.After treatment，TCM symptom scores decreased，inflammatory factors（CRP，TNF-α，IL-6）decreased significantly，and total Lysholm knee scale score increased significantly.TCM symptom scores and inflammatory factors（CRP，TNF-α，IL-6）in the observation group were lower than those in the control group.The total score of Lysholm knee scale was higher than that of control group（P<0.05）.VAS scores of the observation group were lower than those of the control group at 3 d，6 d and 9 d after surgery（P<0.05）. Compared with that of the control group（20.00%，8/40），the complication rate of the observation group（5.00%，2/40）was lower（P<0.05）.After 2 and 4 weeks of treatment，the SF-36 score of the observation group was higher than that of the control group（P<0.05）.

The benefiting vital Qi and nourishing heart method（back Shu-acupoint warm acupuncture）has a good effect on the treatment of kidney Yang deficiency type of knee degenerative diseases.The patient´s symptoms and the knee joint function are improved with less complications.It is a safe and reliable treatment，and the patient´s health is improved after treatment.It is worthy of application.

To analyze the chemical composition of Yinyanghuo（Epimedii Folium）and its processed products and to investigate the proliferative and osteogenic effects of its extracts on mouse Embryonic Preosteoblast Cells（MC3T3-E1 cells）.

Ten batches of Yinyanghuo（Epimedii Folium）were processed into 10 batches of Yinyanghuo（Epimedii Folium）processed with lanolin oil and 10 batches of Yinyanghuo（Epimedii Folium）processed with salt，respectively.The contents of flavonoids in the samples were determined by high performance liquid chromatography（HPLC），and the changes of flavonoids in Yinyanghuo（Epimedii Folium）before and after processing were explored by HPLC fingerprint and multivariate statistical analysis.The osteogenic inhibition model of MC3T3-E1 cells induced by dexamethasone（DEX）was established.The anti-osteoporosis effect of Epimedium and its processed products were evaluated by measuring the expressions of alkaline phosphatase（ALP），osteoprotegerin（OPG）and osteocalcin（OCN）in cells，and the possible reasons for the different anti-osteoporosis effects of Yinyanghuo（Epimedii Folium）and its processed products were further explored.

The HPLC fingerprints of Yinyanghuo（Epimedii Folium）and its processed products were established，and the similarity of the fingerprints was evaluated，and 16 common peaks were identified.The results of cluster analysis classified epimedin A，epimedin B and epimedin C into one group，and icariin and baohuoside I into one group.The polar coordinate bubble diagram of each flavonoid content showed that the contents of primary flavonoid glycosides（epimedin A，epimedin B and epimedin C）decreased overall after processing，and the contents of secondary flavonoid glycosides（icariin and baohuoside I）increased overall after processing.The data of anti-osteoporosis activity showed that different processed products of Yinyanghuo（Epimedii Folium）had certain osteogenic proliferation effect，and the salt-processed Yinyanghuo（Epimedii Folium）had the most obvious effect on the enhancement of osteoblast activity inhibited by DEX.

Fingerprint similarity analysis and cluster analysis were used to analyze the differences in the contents of five flavonoids，so as to preliminarily explore the changes of flavonoids before and after processing. Combined with the effect of its extract on the proliferation and osteogenic ability of MC3T3-E1 cells，it was found that the content of icariin increased after salt processing of Yinyanghuo（Epimedii Folium），and the proliferation of osteogenic inhibition of MC3T3-E1 cells induced by DEX was significantly enhanced，suggesting that icariin may be the material basis for different anti-osteoporosis clinical effects of different processed Yinyanghuo（Epimedii Folium）products，laying a foundation for further exploration of the processing principle of Yinyanghuo（Epimedii Folium）.

To explore the clinical effect of Shugan Jieyu Xiaopi Prescription（疏肝解郁消痞方）in the treatment of functional dyspepsia（FD）of liver-stomach disharmony syndrome complicated with insomnia.

A total of 96 patients with FD of liver-stomach disharmony syndrome combined with insomnia admitted to the hospital from August 2021 to August 2023 were selected and divided into observation group（48 cases）and control group（48 cases）according to random number table method.The control group was given routine intervention，the observation group combined Shugan Jieyu Xiaopi Prescription.The course of treatment in both groups was 1 month.The clinical effect of the two groups was compared.Before treatment and 1 month after treatment，traditional Chinese medicine（TCM）syndrome scores，Nipin dyspepsia Symptom Index（NDSI），Nipin dyspepsia Life Quality Index（NDLQI），Pittsburgh Sleep Quality Index（PSQI），gastrointestinal hormones［motilin（MLT），gastrin（GAS），ghrelin］，neurotransmitters［5-hydroxytryptamine（5-HT），norepinephrine（NE）γ-aminobutyric acid（GABA）］and inflammatory factors［interleukin-6（IL-6），tumor necrosis factor-α（TNF-α）］were recorded and compared between the two groups.The occurrence of adverse reactions in the two groups was recorded.

The total effective rate of observation group was significantly higher than that of control group（P<0.05）.After treatment，the TCM syndrome scores of both groups were significantly decreased（P<0.05），and the score of the observation group was significantly lower than that of the control group（P<0.05）.After treatment，NDSI and PSQI scores of both groups were significantly decreased，and the scores of the observation group were significantly lower than those of the control group（P<0.05）.NDLQI scores of both groups were increased，and the score of the observation group was significantly higher than that of the control group（P<0.05）.After treatment，the levels of MLT and GASwere significantly decreased in both groups，and the levels of the observation group were significantly lower than those of the control group（P<0.05），the levels of ghrelin were increased in both groups，and the level of the observation group was significantly higher than that of the control group（P<0.05）.After treatment，the levels of NE in both groups were significantly decreased，and the level of the observation group was significantly lower than that of the control group（P<0.05）.The levels of 5-HT and GABA in both groups were increased，and the levels of the observation group were significantly higher than those of the control group（P<0.05）.After treatment，the levels of IL-6 and TNF-αwere significantly decreased in both groups，and the levels of the observation group were significantly lower than those of the control group（P<0.05）.There was no significant difference in the total incidence of adverse reactions between the two groups（P>0.05）.

Shugan Jieyu Xiaopi Prescription has a high efficacy in FD of liver-stomach disharmony syndrome complicated with insomnia.It can reduce the symptoms of patients，improve their sleep quality，gastrointestinal hormone and neurotransmitter levels，inhibit inflammation，and have a high safety.

To explore the effect of Xuanfei Huazhuo Formula（宣肺化浊方）on the expressions of CD86 and CD206 in alveolar lavage fluid of patients with sepsis lung injury with turbid toxin accumulation syndrome.

Sixty patients with sepsis induced lung injury（turbid toxin internal accumulation syndrome）who visited Hebei Provincial Hospital of Traditional Chinese Medicine from September 2022 to September 2023 were selected as the study subjects.The participants were randomly divided into an experimental group and a control group using a random coding table，with 30 cases in each group.The control group were given an equal amount of warm water as a control，while the experimental group were given nasal feeding of Xuanfei Huazhuo Formula on the basis of routine treatment.The total treatment period for both groups was 7 days.The 28-d mortality rate，clinical efficacy，severity of the condition，serum inflammatory response indicators，blood gas indicators，respiratory function indicators and expressions of CD86 and CD206 in alveolar macrophage phenotype in alveolar lavage fluid were compared between two groups.

Compared to the control group，the experimental group showed a higher overall effective rate and a lower 28-day mortality rate（P<0.05）.After treatment，the Acute Physiology and Chronic Health Evaluation（APACHE）Ⅱscore and lung injury score（LIS）of both groups decreased（P<0.05），and compared to the control group，the LIS score of the experimental group was lower（P<0.05）.After treatment，the levels of C-reactive protein（CRP），procalcitonin（PCT），interleukin-6（IL-6），tumor necrosis factor-α（TNF-α）and interleukin-10（IL-10）in both groups were reduced（P<0.05），and compared with the control group，the experimental group had lower levels of these indicators（P<0.05）.After treatment，the levels of arterial partial pressure of oxygen（PaO₂）and PaO₂/FiO₂ in both groups increased，while the levels of extravascular lung water index（EVLWI）and pulmonary vascular permeability index（PVPI）decreased（P<0.05）. Compared with the control group，the experimental group performed better on these indicators（P<0.05）.After treatment，the expression of CD68 increased and the expression of CD206 decreased in the alveolar lavage fluid of both groups（P<0.05），and compared to the control group，the experimental group had higher expression of CD68 and lower expression of CD206（P<0.05）.

Xuanfei Huazhuo Formula has definite therapeutic effect in treating patients with sepsis induced lung injury due to the accumulation of turbid toxin.Its mechanism of action may be closely related to the regulation of CD86 and CD206 in alveolar lavage fluid，and has clinical application and promotion value.

To observe the effects of Modified Buzhong Yiqi Huoxue Decoction（加味补中益气活血汤）combined with consciousness-restoring and orifice-opening acupuncture and old ten needles on the nutritional status and neurological function of the elderly patients with cerebral infarction of Qi deficiency and blood stasis syndrome.

One hundred and twenty elderly patients with cerebral infarction with Qi deficiency and blood stasis syndrome were randomly divided into the conventional group（routine treatment+Modified Buzhong Yiqi Huoxue Decoction+routine acupuncture）and the experimental group（routine treatment+Modified Buzhong Yiqi Huoxue Decoction+consciousness-restoring and orifice-opening acupuncture and old ten needles），with 60 cases in each group.The TCM syndrome scores，neurological function，hemorheological indexes and nutritional status before and after treatment were compared between the two groups.The clinical efficacy and adverse reactions were also compared.

After treatment，the TCM main symptom scores，secondary symptom scores，total score，National Institutes of Health Stroke Scale（NIHSS）score，oxidized low-density lipoprotein（ox-LDL），neuronal nuclear antigen（NeuN），whole blood viscosity（BV），whole blood reduced viscosity（BRV）and plasma viscosity（PV）in both groups were lower than those before treatment（P<0.05），and those in the experimental group were lower than those in the conventional group（P<0.05）.After treatment，the Mini Nutritional Assessment（MNA）score，the levels of albumin（ALB）and prealbumin（PA）in both groups were higher than those before treatment（P<0.05），and those in the experimental group were higher than those in the conventional group（P<0.05）.The distribution of clinical efficacy grades and the total effective rate in the experimental group were higher than those in the conventional group（P<0.05）.There were no obvious adverse reactions in the conventional group，and one case of redness and swelling at the acupuncture site in the experimental group，which relieved without intervention.

Modified Buzhong Yiqi Huoxue Decoction combined with consciousness-restoring and orifice-opening acupuncture and old ten needles can improve the TCM syndrome，neurological function，hemorheological indexes and nutritional status of the elderly patients with cerebral infarction of Qi deficiency and blood stasis syndrome and enhance the clinical efficacy，with high safety.

To study the therapeutic effect of Jiawei Diyu Powder（加味地榆散）on lung cancer targeted therapy in patients with oral mucositis of Yin deficiency and heat toxin syndrome.

86 patients with lung cancer targeted therapy for oral mucositis with Yin deficiency and heat toxin syndrome were randomly divided into two groups according to the order of treatment.There were 43 cases in each group.The patients in the control group were treated with Compound Chlorhexidine Gargle and oral administration of vitamin B₂ and vitamin C，and those in the observation group were treated with Jiawei Diyu Powder on the basis of the control group.The oral mucositis grading，TCM symptom scores（dry mouth and throat，sore mouth and tongue，swollen gums and pain，hand-foot-heart heat），inflammatory factor levels［serum interleukin-6（IL-6），interleukin-8（IL-8）and tumor necrosis factor（TNF-α）］，Karnofsky performance score（KPS）and adverse reactions（abnormal taste，yellow tongue coating，nausea and vomiting，belching，etc.）were compared between the two groups.

There was no significant difference in the classification of oral mucositis between the two groups before treatment（P>0.05）.After treatment，the observation group was significantly better than the control group（P<0.05）.After treatment，the above scores of the two groups were significantly decreased（P<0.05），and the scores of TCM symptoms in the observation group were significantly lower than those in the control group（P<0.05）.There was no significant difference in serum IL-6，IL-8 or TNF-αbetween the two groups before treatment（P>0.05）.After treatment，the levels of inflammatory factors in the two groups were significantly decreased（P<0.05），and the levels of the observation group were significantly lower than those of the control group（P<0.05）.After treatment，the KPS scores of the two groups were significantly increased，and the score of the observation group was significantly higher than that of the control group（P<0.05）.The incidence of adverse reactions in the observation group and the control group was 9.30%（4/43）and 6.98%（3/43），respectively，and the difference was not statistically significant（P>0.05）.

Jiawei Diyu Powder has a satisfactory therapeutic effect on patients with lung cancer targeted treatment of oral mucositis with Yin deficiency and heat toxin syndrome.It can significantly improve the classification of oral mucositis，eliminate the inflammation，relieve various discomfort symptoms，and improve the health level of the body.It is a safe and effective medication regimen.

To investigate the effects of Baishao（Radix Paeoniae Alba）on rats with irritable bowel syndrome with diarrhea（IBS-D）and irritable bowel syndrome with constipation（IBS-C）.

Sixty-six SD male rats aged 4 weeks were randomly divided into normal control group，IBS-D model group，IBS-D drug group［high，medium and low doses of Baishao（Radix Paeoniae Alba）and pivilium bromide］，IBS-Cmodel group and IBS-C drug group［high，medium and low doses of Baishao（Radix Paeoniae Alba）and moxapride］.Acetic acid stimulation combined with binding stress was used for IBSD modeling，and ice water gavage combined with binding stress was used for IBS-C modeling.The high，medium and low dose groups were administrated with Baishao（Radix Paeoniae Alba）（7.2，3.6，1.8 g/kg body mass，respectively），piverium bromide aqueous solution（13.5 mg/kg）and moxabi aqueous solution（1.35 mg/kg）for 2 weeks，respectively.The weight was performed，the stool was collected，the abdominal withdrawal reflex（AWR）score was performed.The expressions of vasoactive intestinal peptide（VIP）and nuclear transcription factorκB（NF-κB）in ileocecal colon were detected by immunohistochemistry and ELISA.The expression of protease activating receptor 2（PAR2）in intestinal tissues was detected by Western blot.

（1）IBS-D：Baishao（Radix Paeoniae Alba）at high，medium and low doses and piveronium bromide could improve visceral hypersensitivity in model rats（P<0.05，P<0.01，P<0.01，P<0.01，respectively）.Baishao（Radix Paeoniae Alba）at middle and low doses and piveronium bromide could reduce the fecal water content of model rats（P<0.01），but Baishao（Radix Paeoniae Alba）at high dose had no significant effect on reducing fecal water content of model rats（P>0.05）.The weight gain of model group was lower than that of the normal control group（P<0.01），and Baishao（Radix Paeoniae Alba）at high dose could reduce the weight gain of the model group（P<0.05）.Baishao（Radix Paeoniae Alba）at high dose could decrease the expression of NF-κB in model rats（P<0.01）.Baishao（Radix Paeoniae Alba）at high and medium doses could decrease the expression of PAR2 in model mice（P<0.01，P<0.05）.（2）IBS-C：Baishao（Radix Paeoniae Alba）at medium and low doses could improve visceral hypersensitivity of model rats（all P<0.05）.Baishao（Radix Paeoniae Alba）at high dose could increase fecal water content of model rats（P<0.01）.The weight gain of the model group was lower than that of the normal control group（P<0.05），and the drug group had no effect on the body weight of the model rats（all P>0.05）.Baishao（Radix Paeoniae Alba）at high dose and mosapride could decrease VIP expression in model rats（P<0.05，P<0.01）.Baishao（Radix Paeoniae Alba）at low dose could decrease PAR2 expression in IBS-Cmodel rats（P<0.05）.

Baishao（Radix Paeoniae Alba）can improve the visceral hypersensitivity of the rats with IBS-D and IBS-C at the same time，which may be related to the decrease of PAR2 expression.Medium and low doses of Baishao（Radix Paeoniae Alba）can alleviate diarrhea of the rats with IBS-D，while high doses of Baishao（Radix Paeoniae Alba）can promote defecation of the rats with IBS-C，which may be related to the difference of multi-target effects of Baishao（Radix Paeoniae Alba）on different models.

To analyze the effect of Buyi Jianpi Recipe（补益健脾方）on hormone，plasma fibrinogen and prognosis of postpartum lochia with Qi deficiency and blood stasis.

Ninety-six cases of postpartum lochia with Qi deficiency and blood stasis syndrome were randomly divided into the study group and the control group，with 48 cases in each group.Both groups were treated with hemostasis，anti-infection and uterine contraction，while the study group was treated with Buyi Jianpi Recipe for 2 weeks.The changes of TCM syndrome scores，serum hormones，plasma fibrinogen and uterine artery hemodynamics were compared between the two groups before and after treatment，and the therapeutic effect and safety of the two groups were evaluated.

After treatment，the scores of postpartum lochia，tongue picture，pulse and abdominal pain in both groups decreased compared with those before treatment.After treatment，the scores of postpartum lochia，tongue picture，pulse and abdominal pain in the study group were lower than those in the control group with statistical significance（P<0.05）.After treatment，the levels of progesterone（P）andβ-human chorionic gonadotropin（β-HCG）decreased and the level of estrogen（E₂）increased in both groups.After treatment，the levels of P andβ-hCG in the study group were lower than those in the control group，and the level of E₂ was higher than that in the control group with statistical significance（P<0.05）.The levels of fibrinogen（FIB）and D-dimer（D-D）in both groups decreased after treatment.The levels of FIB and D-D in the study group were lower than those in the control group after treatment，and the difference was statistically significant（P<0.05）.After treatment，the values of resistance index（RI）and pulse index（PI）in both groups decreased，and the values of end diastolic blood flow velocity（EDV）and peak systolic velocity（PSV）increased.After treatment，the values of RI and PI of the study group were lower than those of the control group，and the values of EDV and PSV of the study group were higher than those of the control group with statistical significance（P<0.05）.The total effective rate of the study group after treatment was93.75%（45/48），which was higher than that of the control group（79.17%，38/48），and the difference was statistically significant（P<0.05）.No obvious adverse reactions occurred in both groups during treatment.

For the treatment of postpartum lochia with Qi deficiency and blood stasis，Buyi Jianpi Recipe can not only improve the hormone level，coagulation and fibrinolysis function，and uterine artery hemodynamics，but also alleviate the clinical symptoms and improve the prognosis on the premise of ensuring safety.

To investigate the effects of Huangqi Guizhi Wuwu Decoction（黄芪桂枝五物汤）on microRNA-146a（miR-146a），myeloid differentiation factor 88（MyD88）/inhibitor of nuclear factor-κB inhibitory protein（IκB）signaling pathway in diabetic peripheral neuropathy（DPN）patients.

A total of 108 DPN patients were selected and divided into treatment group and control group by random number table method，with 54 cases in each group.The control group was treated with mecobalamine and vitamin B₁，and the treatment group was treated with Huangqi Guizhi Wuwu Decoction.The course of treatment in both groups was 3 months.The clinical efficacy of the two groups was evaluated.Traditional Chinese medicine（TCM）syndrome score，sensory nerve conduction velocity（SNCV），motor nerve conduction velocity（MNCV），Toronto Clinical Scoring System（TCSS）score，the levels of miR-146a，MyD88 protein，IκBαprotein and phosphorylated-IκBα（p-IκBα）protein before and after treatment and the occurrence of adverse reactions were compared between the two groups.

The total effective rate of the treatment group was 92.59%（50/54），which was significantly better than 77.78%（42/54）of the control group（P<0.05）.After treatment，the scores of TCM syndrome in both groups were improved compared with those before treatment（P<0.05），and the treatment group was better than the control group（P<0.05）.After treatment，the total knee SNCV，median SNCV，total knee MNCV，median MNCV and TCSS scores of both groups were improved compared with those before treatment（P<0.05），and the treatment group was better than the control group（P<0.05）.After treatment，the levels of miR-146a，MyD88 protein，IκBαprotein and p-IκBαprotein in the treatment group were improved compared with those before treatment（P<0.05），and the treatment group was better than the control group（P<0.05）.There was no difference in the incidence of adverse reactions between the two groups（P>0.05）.

Huangqi Guizhi Wuwu Decoction has good efficacy in DPN.It can effectively reduce clinical symptoms，improve nerve conduction velocity，inhibit the expressions of miR-146a and MyD88/IκB signaling pathway，and has high safety.

To explore the mechanism of Yangxue Qingnao Granules（养血清脑颗粒）combined with Qiangli Dingxuan Tablets（强力定眩片）in treating dizziness and headache caused by hypertension.

A total of 200 patients with hypertension，dizziness and headache were selected.The participants were randomly divided into an experimental group and a control group using a random coding table，with 100 patients in each group.The control group received routine treatment，while the experimental group received Yangxue Qingnao Granules combined with Qiangli Dingxuan Tablets on the basis of the control group.Both groups were treated continuously for 4 weeks.The cognitive function，clinical efficacy，blood pressure control，improvement of dizziness and headache symptoms，serum levels of C-reactive protein（CRP），homocysteine（Hcy），vascular endothelial growth factor（VEGF），arterial blood flow velocity and complications were compared between the two groups.

After treatment，the MMSE and MoCA scores of the two groups increased（P<0.05）. Compared with the control group，the experimental group had higher MMSE and MoCA scores（P<0.05）. Compared with that of the control group，the total effective rate of the experimental group was higher（P<0.05）.The scores of the quality of life of two groups increased（P<0.05）. Compared with that of the control group，the score of the quality of life of the experimental group was higher（P<0.05）.The systolic and diastolic blood pressures of two groups decreased（P<0.05）. Compared with the control group，the experimental group had lower systolic and diastolic blood pressure，and shorter improvement time for dizziness and headache（P<0.05）.The levels of CRP and Hcy decreased and VEGF levels increased in both groups（P<0.05）. Compared with the control group，the experimental group had lower levels of CRP and Hcy，and higher VEGF levels（P<0.05）.The average blood flow velocity of left vertebral artery（LVA），right vertebral artery（RVA）and basilar artery（BA）in the two groups increased（P<0.05）. Compared with those of the control group，the average blood flow velocity of LVA，RVA and BA in the experimental group was faster（P<0.05）. Compared with the control group，there was no significant difference in the incidence of complications in the experimental group（P>0.05）.

The combination of Yangxue Qingnao Granules and Qiangli Dingxuan Tablets can effectively improve the effect of blood pressure control，improve the dizziness and headache symptoms caused by hypertension，and improve the quality of life of patients.The mechanism may be closely related to the regulation of CRP，Hcy and VEGF levels and arterial blood flow velocity，which is suitable for clinical application and promotion.