To understand the epidemiological characteristics of non-occupational carbon monoxide poisoning incidents in Beijing from 2018 to 2022, and to explore targeted prevention and control measures.

The data were from the National Public Health Emergency Reporting Management Information System. Descriptive epidemiological methods were used to analyze non-occupational carbon monoxide poisoning incidents in Beijing from 2018 to 2022. Relative risk (RR) was used to assess the risk of morbidity and mortality.

From 2018 to 2022, a total of 1841 non-occupational carbon monoxide poisoning incidents were reported in Beijing, with 2729 cases of poisoning and 31 deaths. The annual morbidity and mortality were 25.14 and 0.29 cases per million, respectively. There were two peaks of poisoning cases in spring and winter, accounting for 49.98% and 24.00% of the total cases, respectively. The highest incidence occurred between 8 and 11 o ’clock, accounting for 22.83%. In the inner suburbs, outer suburbs and urban areas, the incidence of non-occupational carbon monoxide was 0.96 cases/100 000, 1.27 cases/100 000 and 18.79 cases/100 000, and the mortality was 0.02 cases/100 000, 0.02 cases/100 000 and 0.11 cases/100 000, respectively. The poisoning incidents mainly occurred in residential families in 1633 cases, accounting for 88.70%; This was followed by 118 restaurants, accounting for 6.41 percent. The proportion of household poisoning incidents decreased from 92.10% in 2018 to 84.13% in 2022. The proportion of poisoning incidents in restaurants increased year by year from 4.23% in 2018 to 10.05% in 2022. The proportion of poisoning cases occurring at home decreased from 86.39% in 2018 to 71.84% in 2022. The proportion of poisoning cases in restaurants increased from 9.88% in 2018 to 20.57% in 2022.

The incidence and death risk of non-occupational carbon monoxide poisoning in Beijing is not balanced among regions, and the proportion of poisoning incidents in restaurants is increasing year by year. Targeted measures should be taken to strengthen the prevention and control work in the outer suburbs and key restaurants.

To analyze the co-morbidity of spinal curvature abnormality and myopia and the relevant factors in primary and middle school students in Guangzhou from 2019 to 2023, so as to provide references for the establishment of the mechanism of Co-morbidity, Shared Etiology, and Shared Prevention of common diseases in students.

From September 2019 to 2023, used stratified random cluster sampling, 4 248, 4 230, 4 266, 25 476, 25 587 primary and middle school students were selected as subjects for spinal curvature abnormality and myopia screening and questionnaire survey. The χ²test was used for comparing the group differences and univariate analysis. The multivariable logistic regression model was used to explore the influencing factors of their co-morbidity.

the co-morbidity rates of spinal curvature abnormality and myopia were 2.96%-6.00% from 2019 to 2023 in primary and middle school students in Guangzhou. The differences in the co-morbidity rates among students of each phases of studying and the difference of the co-morbidity rate in primary and middle school students over the past 5 years were statistically significant (P<0.05). Multivariate logistic regression analysis showed that low BMI junior and senior high school students (OR=1.72, 1.89, 95%CI: 1.11-2.67, 1.47-2.41) were more likely to suffer these two diseases. Primary school students in grades 4 to 6 who had menarche or spermatorrhea (OR=1.77, 95%CI: 1.04-3.02), screening time 2-<3h or≥3h per day (OR=3.06, 2.28, 95%CI: 1.41-6.68, 1.02-5.19), outdoor activities time<2h per day (OR=2.28, 95%CI: 1.22-4.26), junior high school students with low BMI (OR=1.72, 95%CI: 1.11-2.67), whose teacher "never or occasionally" reminded reading and writing posture (OR=1.50, 95%CI: 1.06-2.12), who were not strict with requiring standing and sitting posture themselves (OR=2.51, 1.99, 95%CI: 1.29-4.86, 1.06-3.74), senior high school students with low BMI (OR=1.89, 95%CI: 1.47-2.41) who had activities in the teaching building during recess (OR=1.33, 95%CI: 1.02-1.75), distance from chest to the edge of table "never or occasionally" more than 1 fist away during reading and writing (OR=1.27, 95%CI: 1.05-1.53) had a higher risk of spinal curvature abnormality and myopiaco-morbidity (P<0.05).

The co-morbidity of spinal curvature abnormality and myopia was associated with daytime outdoor exercise and sedentary behavior with bad posture. Early screening and early treatment of spinal curvature abnormality and myopia should be strengthened among adolescent students, especially in urban, female and emaciated students.

To study the effects of superfine grinding treatment on the composition and efficacy of loquat branches.

After the loquat branches were superfine grinding treated, the contents of total phenols, total flavonoids, polysaccharides, ursolic acid, oleanolic acid in the extracts from loquat branches with different particle sizes were detected by spectrophotometry and high-performance liquid chromatography. The in vitro antioxidant capacity of extracts from superfine loquat branches was evaluated by DPPH, ABTS free radical scavenging assay and FRAP assay. SPF-grade male Kunming mice were randomly divided into blank/model control group, drug group, loquat leaf control group, and low, medium, and high dosage of superfine loquat branches according to their body weights. The expectorant effect of extracts from superfine loquat branches was evaluated by phenol red excretion assay, and the antitussive effect of extracts from superfine loquat branches was evaluated by ammonia-induced cough assay.

The total phenol, total flavonoid and oleanolic acid contents of the three particle size loquat branch groups were higher than those of the branch control group (P<0.05, P<0.01), the total phenol and total flavonoid contents of the 220-mesh and 400-mesh loquat branch groups were higher than those of the leaf control group (P<0.05), and the ursolic acid contents of the 220-mesh and 400-mesh loquat branch groups were higher than those of the branch control group (P<0.01). In the in vitro experiment, the DPPH IC₅₀ and ABTS IC₅₀ of the three particle size loquat branch groups were lower than that of the branch control group (P<0.05), and the FRAP value was higher than that of the branch control group (P<0.05), and the DPPH IC50 and ABTS IC50 of the 200 mesh and 400 mesh loquat branch groups were lower than that of the leaf control group (P<0.05), and the FRAP value was higher than that of the leaf control group (P <0.05). In the phenol red excretion experiment, the phenol red excretion was significantly elevated in mice in the high-dose superfine loquat branch group (P<0.05). In the ammonia-induced cough experiment, both medium-dose and high-dose superfine loquat branches groups prolonged the latency period of coughing and the number of coughs in mice (P<0.05).

Appropriate superfine grinding treatment can increase the content of the efficacy components of loquat branches, enhance their antioxidant effect, and at the same time, they have certain expectorant and antitussive effects.

To analyze the impact of nighttime sleep duration on depressive symptoms in the lifestyle habits of elderly people with multiple comorbidities in China.

Using the fifth round of the China Health and Retirement Longitudinal Study project, the depression mood of elderly people with multiple comorbidities was evaluated based on the Center for Disease Control Depression Rating Scale (CSE-D-10). Nighttime sleep was divided into five levels:<6 h, 6 to <7 h, 7 to <8 h, 8 to <9 h, and ≥9 h. Multivariate logistic regression analysis was conducted to investigate the influencing factors of depression in elderly people with multiple comorbidities. Random forest model was used to analyze the importance of nighttime sleep in the risk of depression in elderly people with multiple comorbidities. Restrictive cubic spline curves were used to further explore the dose-response relationship between nighttime sleep duration and the risk of depression.

A total of 1 249 elderly individuals with multiple comorbidities were included, aged (68.51±5.91) years. Multivariate logistic regression analysis showed that the risk of depression in elderly individuals with multiple comorbidities who slept at night for 6 to <7 hours (OR=0.447 (95%CI: 0.309-0.646)), 7 to <8 hours (OR=0.550 (95%CI: 0.351-0.862)), and 8 to <9 hours (OR=0.498 (95%CI: 0.323-0.768)) was relatively lower compared to those who slept for less than 6 hours. Discomfort caused by pain, ADL, life satisfaction, and stroke are the influencing factors for depression in elderly people with multiple comorbidities (P<0.05). The results of the random forest model show that the importance score of nighttime sleep on depression symptoms is relatively high. The results of the restricted cubic spline curve indicate a non-linear relationship between nighttime sleep and the risk of depression symptoms. The risk of depression symptoms decreases with 6-8 hours of nighttime sleep, and increases with less than 6 hours or more than 8 hours of nighttime sleep.

Nighttime sleep has an impact on the occurrence of depression in elderly people with multiple comorbidities. It is recommended that elderly people maintain 6-8 hours of nighttime sleep to effectively reduce the risk of depression and have certain significance for early prevention and control of depression in the elderly population.

To analyze whether there is a threshold effect between thyroid hormone sensitivity indexes and breast cancer, and to analyze the subgroup analysis and interaction test of age.

2 892 adults from NHANES were collected between 2007 and 2012, including 83 breast cancer patients. Central thyroid hormone sensitivity indices were calculated, including Thyroid Feedback Quantile Index for T4(TFQI_FT4) and T3(TFQI_FT3), Thyroid Stimulating Hormone T4 Resistance Index(TT4RI), Thyroid Stimulating Hormone T3 Resistance Index(TT3RI), and TSH Index(TSHI), as well as peripheral thyroid hormone sensitivity index FT3/FT4. The association between breast cancer and the thyroid system was investigated using a multivariable logistic regression model. Smooth curve fitting and stratified analysis were used too, and subgroup analysis and interaction tests were performed based on age.

Model3 showed that Thyroid Stimulating Hormone (TSH) (OR=1.33, 95%CI:1.08-1.63), TFQI_FT4(OR=2.61, 95%CI:1.25-5.45), TFQI_FT3(OR=3.15, 95%CI:1.18-8.44), TT4RI(OR=1.03, 95%CI:1.01-1.05), TT3RI(OR=1.10, 95%CI:1.03-1.18), and TSHI(OR=1.68, 95%CI:1.14-2.50) were significantly positively associated with the risk of breast cancer. A linear relationship with breast cancer was observed when TFQI_FT3≥0.7, TSHI≥2.4, and TT4RI<50(P<0.05). TFQI_FT4 showed a threshold effect(likelihood ratio test=0.040) when TFQI_FT4<0.25. The relationship between TFQI_FT4 and breast cancer was not significant(OR=1.07, 95%CI:0.36-3.15), but when TFQI_FT4≥0.25, it was significantly associated with an increased risk of breast cancer(OR=12.79, 95%CI:2.50-65.40). Subgroup analysis further revealed that in women over 55 years old, increased central thyroid hormone sensitivity indices were associated with breast cancer risk(P<0.05).

Increased central thyroid hormone sensitivity indices are significantly associated with the risk of breast cancer, which may be a potential indicator for breast cancer detection in the future.

To analyze the late diagnosis of newly reported HIV/AIDS in Hebei province from 2016 to 2022, and to understand the proportion of late diagnosis of HIV/AIDS and its influencing factors.

The information of newly reported HIV/AIDS cases in Hebei province from 2016 to 2022 was collected through the national basic information system of HIV/AIDS, and identified relevant cases by definition of late diagnosis. Trend Chi-square test was used to analyze the changing trend of late diagnosis proportion, the influencing factors of late diagnosis were analyzed by Chi-square test and Logistic regression model.

From 2016 to 2022, 14 689 HIV/AIDS cases were newly reported in Hebei province, and the proportion of late diagnosis was 33.1%. The proportion of late diagnosis showed an upward trend in each year (χ²=69.826, P<0.001). The results of Logistic regression showed that the proportion of late diagnosis was higher in the farmers, the source of testing consulting and medical institutions and other, and the higher age group. The OR (95%CI) of farmers was 1.154 (1.021-1.303) compared with the household workers, and the unemployed. Compared with the custodial population, the OR (95%CI) of testing counseling and medical institutional and other sources were 1.909 (1.236-2.949), 3.205 (2.08-4.938) and 1.808 (1.136-2.875). The OR (95%CI) of each age group was 1.945 (1.469-2.577), 3.279 (2.458-4.375), 3.996 (2.97-5.377), 5.223 (3.87-7.05) and 5.202 (3.814-7.095), respectively. The proportion of late diagnosis varies greatly in different cities, City 5, City 11 and City 1 was higher than the average of the whole province.

From 2016 to 2022, the proportion of late diagnosis HIV/AIDS cases in Hebei province is increased in each year, and there are big regional differences. Occupation, sample source and age are the influential factors of late diagnosis, targeted measures should be taken to prevent and improve the ability of early detection.

To investigate the relationship between total cholesterol (TC) levels, snoring condition with Metabolic Syndrome (MetS) in a population of 30-79 years old from the Dong ethnic minority in Guizhou Province, and to further analysethe interaction between the two on MetS.

The data of this study came from the database of the “Natural Population Cohort Study in the Gathering Places of Ethnic Minorities in Southwest China”, and a total of 5 815 people of Dong ethnic group aged 30-79 years in Guizhou Province were included, and used binary logistic regression to analyse the associations of TC level and snoring condition with MetS, respectively. A multiplicative model and an additive model were constructed for assessing the association of the interaction between TC level and snoring condition with MetS.

The detection rate of metabolic syndrome was 22.08% in the population of the hereditary Dong ethnic group aged 30-79 years in Guizhou Province. In the total population, TC levels ≥5.20 mmol/L were found to be positively associated with MetS compared to participants with TC levels <5.20 mmol/L (OR=2.19, 95%CI: 1.93-2.49). In addition, snoring was positively associated with the MetS prevalence (OR:2.17, 95% CI:1.19-2.47). There was no multiplicative but additive interaction between TC level and snoring condition on MetS in the total population (the relative excess risk due to interaction=1.10, 95% CI: 0.41-1.79; the attributable proportion due to interaction=0.25, 95% CI: 0.12-0.39; the synergy index=1.49, 95% CI: 1.15-1.92).

In the prevention and control of MetS, attention should be paid not only to biochemical indicators such as TC levels, but also to the effect of snoring on the disease. By cultivating a healthy lifestyle, TC levels can be reduced and snoring can be improved with a view to playing a positive role in the management and control of MetS.

To explore the relationship between social media addiction and anxiety among college students and the role of bedtime procrastination and stress perception.

A total of 15493 college students were selected by convenience sampling in September 2023 with using the Bergen Social Networking Addiction Scale, the Bedtime Procrastination Scale, the Chinese Perceived Stress Scales and the Generalized Anxiety Disorder 7-item Scale. SPSS25.0 macro program PROCESS was used to analyze the mediating effect of bedtime procrastination and the moderating effect of stress perception.

The social media addiction was positively predicted college students’ anxiety (β=0.307, P<0.001). Bedtime procrastination partially mediated the relationship between social media addiction and anxiety in the college students. The mediation effect value was 0.060 (95% Bootstrap CI=[0.055-0.065]), the mediating effect accounted for 19.54% of the total. Stress perception moderated the relationship between bedtime procrastination and anxiety (β=0.094, P<0.001). As the level of perceived stress increased, the positive association between bedtime procrastination and anxiety became stronger.

Social media addiction can directly affect anxiety in the college students, or indirectly affect it through bedtime procrastination, and perceived stress moderates the path from bedtime procrastination to anxiety in the mediation model.

To evaluate the information quality of hypertension-related videos on the TikTok short video platform and assess their potential value for public health education.

In June 2024, we searched the TikTok short video platform using the keyword "hypertension" selecting the top 200 videos and ultimately including 177 videos for quality evaluation. Structured content integrity assessment tools and the DISCERN video quality assessment tool were used to evaluate the videos. The correlation between video quality and characteristics (duration, likes, comments, favorites, and shares) was studied.

The 177 videos received 11 250 432 likes, 366 588 comments, 3 265 929 favorites, and 3 780 513 shares. The median video length was 111 seconds (74, 158), and the median upload days were 672 days (147, 878). 89.3% of the videos were posted by doctors, 8.5% by individual science communicators, and 2.3% by news agencies. 98.9% of the videos had subtitles, all featured individuals, and only 26.0% included animated demonstrations. Content integrity scores were: definition 0.19±0.40, symptoms 0.11±0.32, risk factors 0.29±0.50, assessment 0.36±0.45, management 0.81±0.47, and outcomes 0.63±0.58. 90.4% of the videos had a DISCERN score of ≤50, indicating "average" or below quality, with no significant difference in DISCERN scores among different publishers (P>0.05). DISCERN scores were significantly correlated with video duration (r=0.409, P<0.001).

The overall quality of hypertension-related videos on TikTok is low, with a significant positive correlation between video duration and quality. High-quality videos receive less attention, making TikTok an unsuitable platform for hypertension education due to low information quality and reliability.

To investigate the relationship between stress-induced hyperglycemia in acute pancreatitis (AP) patients and the risk of developing new-onset diabetes after pancreatitis.

This study selected patients with acute pancreatitis (AP) who had no prior history of diabetes and were hospitalized in the Department of Gastroenterology at Nanjing Drum Tower Hospital, affiliated with Nanjing University, 2015-2019. New-onset diabetes after pancreatitis was diagnosed based on established criteria. The relationship between stress-induced hyperglycemia upon admission and the risk of developing new-onset diabetes was assessed using the COX proportional hazards model. Stratified analyses were conducted based on gender, age, education level, place of residence, marital status, smoking history, admission diagnosis, Body Mass Index (BMI), history of pancreatic necrosis/abscess, and severity of the condition.

This study included a total of 1258 participants. The follow-up incidence of diabetes was 28.3%. Patients who experienced stress-induced hyperglycemia upon admission had a higher risk of developing new-onset diabetes compared to those with normal blood glucose levels (HR=1.40, 95%CI:1.06-1.85). Subgroup analysis indicated that patients who were elderly(HR=2.01, 95%CI:1.19-2.12), male(HR=1.17, 95%CI:1.03-2.35), from rural areas(HR=1.37, 95%CI:1.24-1.53),had a history of smoking(HR=1.25, 95%CI:1.14-1.38), had a history of pancreatic necrosis/abscess(HR=1.34，95%CI:1.07-1.98), BMI≥28 kg/m ? (HR=2.33, 95%CI:1.57-4.553), or had moderate to severe pancreatitis(HR=1.45, 95%CI:1.27-2.58; HR=1.23, 95%CI:1.06-1.93), had a greater risk of developing new-onset diabetes if they experienced stress-induced hyperglycemia.

Stress hyperglycemia at admission is associated with an increased risk of new-onset diabetes after pancreatitis. Effective glucose management in high-risk AP patients with stress hyperglycemia may help reduce the risk of developing new-onset diabetes.