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To investigate the relationship between stress-induced hyperglycemia in acute pancreatitis (AP) patients and the risk of developing new-onset diabetes after pancreatitis.
This study selected patients with acute pancreatitis (AP) who had no prior history of diabetes and were hospitalized in the Department of Gastroenterology at Nanjing Drum Tower Hospital, affiliated with Nanjing University, 2015-2019. New-onset diabetes after pancreatitis was diagnosed based on established criteria. The relationship between stress-induced hyperglycemia upon admission and the risk of developing new-onset diabetes was assessed using the COX proportional hazards model. Stratified analyses were conducted based on gender, age, education level, place of residence, marital status, smoking history, admission diagnosis, Body Mass Index (BMI), history of pancreatic necrosis/abscess, and severity of the condition.
This study included a total of 1258 participants. The follow-up incidence of diabetes was 28.3%. Patients who experienced stress-induced hyperglycemia upon admission had a higher risk of developing new-onset diabetes compared to those with normal blood glucose levels (HR=1.40, 95%CI:1.06-1.85). Subgroup analysis indicated that patients who were elderly(HR=2.01, 95%CI:1.19-2.12), male(HR=1.17, 95%CI:1.03-2.35), from rural areas(HR=1.37, 95%CI:1.24-1.53),had a history of smoking(HR=1.25, 95%CI:1.14-1.38), had a history of pancreatic necrosis/abscess(HR=1.34，95%CI:1.07-1.98), BMI≥28 kg/m ? (HR=2.33, 95%CI:1.57-4.553), or had moderate to severe pancreatitis(HR=1.45, 95%CI:1.27-2.58; HR=1.23, 95%CI:1.06-1.93), had a greater risk of developing new-onset diabetes if they experienced stress-induced hyperglycemia.
Stress hyperglycemia at admission is associated with an increased risk of new-onset diabetes after pancreatitis. Effective glucose management in high-risk AP patients with stress hyperglycemia may help reduce the risk of developing new-onset diabetes.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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