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To explore the relationship between female reproductive history and cognitive dysfunction in old age.
Based on the survey data of the Chinese Longitudinal Healthy Longevity Survey database in 2018, binary logistic regression and R4.3.3 software were used to construct a restricted cubic spline model to analyze the dose-response relationship between the number of births, gestational age and cognitive dysfunction in women.
7508 elderly women were included, of whom 764 (10.17%) had cognitive dysfunction. After adjusting for confounding factors, the first gestational age (OR=1.025, 95%CI:1.007-1.044), the last gestational age (OR=1.071, 95%CI:1.056-1.086), and the number of pregnancies (OR=1.085, 95%CI:1.044-1.127) had an impact on the cognitive function of elderly women. The results of the restricted cubic spline model showed that there was a linear dose-response relationship between the number of pregnancies and the risk of cognitive dysfunction in women (Poverall<0.05, Pnon-linearity=0.67), and the cognitive function was not adversely affected when the number of pregnancies was ≤4 (OR<1, 95%CI:0.45-1). When she had only one child, there was a nonlinear dose-response relationship between the gestational age and the risk of cognitive impairment (Poverall<0.05, Pnon-linearity<0.05), suggesting that the best childbearing age was 27 to 30 years old (OR<1, 95%CI:0.89-1). When she had more than one child, there was a nonlinear dose-response relationship between the first and last gestational age and the risk of cognitive impairment (Poverall<0.05, Pnon-linearity<0.05), suggesting that the best childbearing age was 22 to 35 years old (OR<1, 95%CI: 0.99-1).
There is a correlation between female reproductive history and cognitive function in old age. Limiting the number of childbearing and encouraging age-appropriate childbearing can improve cognitive function in old age.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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