To assess the dietary nutrition status of patients with liver cirrhosis and to explore the relationship between dietary fiber and micronutrient intake and the prevalence of sarcopenia, providing a theoretical foundation for sarcopenia prevention in this patient population.

The current study was conducted among patients with liver cirrhosis in the gastroenterology department of Sichuan Provincial People’s Hospital by purposive sampling from September 2022 to December 2023. The 24-hour dietary recall method was used to collect information on the types and quantities of food consumed by the patients. Whole-body muscle mass was measured using bioelectrical impedance analysis (BIA), and sarcopenia was diagnosed in combination with handgrip strength and 6-meter walking speed. Multiple logistic regression analysis was used to analyze the correlation between energy and nutrient intake and sarcopenia.

A total of 203 patients with cirrhosis were included in the analysis, including 40.4% with sarcopenia. Negative correlations were observed between sarcopenia prevalence and the intake of dietary fiber (OR=0.85, 95% CI: 0.75-0.96), vitamin A (OR=0.87, 95% CI: 0.77-0.98), vitamin C(OR=0.91, 95% CI: 0.86-0.97), potassium (OR=0.88, 95% CI: 0.80-0.97), magnesium (OR=0.93, 95% CI: 0.87-0.99) and copper (OR=0.31, 95% CI: 0.14-0.67). Additionally, an interactive effect was identified between age and the intake of vitamin C, phosphorus, and iron (Pfor interaction<0.05).

Dietary fiber and micronutrient intake are closely related to sarcopenia in patients with cirrhosis. It is crucial to enhance nutritional education for patients with liver cirrhosis and their families, and to consider the use of nutritional supplements when necessary to prevent sarcopenia, particularly in the elderly.

To analyze the disease burden and trend of anxiety disorders in adolescents aged 10-24 in China from 1990 to 2021.

Based on the 2021 global burden of disease (GBD) database, the incidence, prevalence, and disability-adjusted life years (DALYs) rate of anxiety disorders in adolescents aged 10-24, along with their corresponding standardized rates, were extracted as indicators of disease burden. With 1990 as the baseline, the overall and gender- and age-specific changes in these indicators in 2021 were analyzed. Joinpoint regression analysis was used to dynamically analyze the changes in these three disease burden indicators from 1990 to 2021. The grey prediction model GM(1,1) was employed to estimate the disease burden trend of anxiety disorders in adolescents over the next decade.

In 2021, incident case number, prevalent case number, and DALYs of anxiety disorders in adolescents were 1 637 600, 10 267 500, and 12 793 000, respectively, which decreased by 30.51%, 33.91%, and 33.59%, as compared with 1990; however, the standardized incidence, standardized prevalence, and standardized DALYs rate of anxiety disorders in adolescents were 451.49/100 000, 3 481.74/100 000, and 418.95/100 000, respectively, which represented an increase of 2.29%, 2.03%, and 2.37%, as compared to 1990; there are differences in the disease burden for anxiety disorders between genders, which were manifested that girls are more likely to suffer from anxiety disorders than boys; and the standardized incidence of anxiety disorders among adolescents between the ages of 10-14 years was higher, while the standardized prevalence and the standardized DALYs rate among them between the ages of 15-19 years were higher. The Joinpoint regression model showed that the standardized incidence, standardized prevalence, and standardized DALYs rate of anxiety disorders in adolescents aged 10-24 increased from 1990 to 2021, with a larger increase from 2019 to 2021. The grey prediction model indicated that by 2031, the standardized incidence, standardized prevalence, and standardized DALYs rate would reach 559.44/100 000, 3 597.01/100 000, and 430.65/100 000, respectively.

The disease burden of anxiety disorders in adolescents aged 10-24 years is concerning, and interventions for anxiety disorders should be performedinadolescents of different genders and ages.

To explore the impact of hypertension diagnosis and measured blood pressure on depressive symptoms in middle-aged and older adults, providing evidences for depression prevention in this population.

Data from four waves (2013-2020) of the China Health and Retirement Longitudinal Study (CHARLS) were analyzed, including a total of 4 106 participants aged 45 and older. A linear mixed-effects model was used to examine the effect of hypertension on depressive symptoms.

In the univariate analysis, compared to respondents who with undiagnosed hypertension (32.64%), those diagnosed with hypertension showed a higher proportion of depressive symptoms (33.51%). After adjusting for covariates in the multivariate analysis, diagnosed hypertension (OR=1.05, P=0.003) remained associated with a higher risk of depression. However, elevated blood pressure without diagnosis did not have a significant effect on depressive symptoms (OR=0.99, P=0.454).

Hypertension diagnosis is associated with an increased risk of depressive symptoms among middle-aged and elderly individuals. Therefore, clinicians are advised to monitor not only blood pressure control in hypertensive patients but also their mental health, providing psychological support to prevent emotional issues that may arise from the diagnosis, thus enhancing patients’ quality of life.

To explore the relationship between cardiovascular health (CVH) and depression in postmenopausal women.

Utilizing data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018, logistic regression analysis was conducted to examine the association between CVH and depression in postmenopausal women. Restricted cubic spline (RCS) models were employed to reveal potential nonlinear associations between the two.

After adjusting the covariates, the risk of depression was significantly reduced in the moderate and high CVH groups (OR=0.50, 95% CI: 0.34-0.72; OR=0.25, 95% CI: 0.07-0.90). A significant nonlinear association was also observed between CVH and depression (P-overall<0.001, P-nonlinear<0.001). Subgroup analysis results showed a significant negative association between high levels of CVH and depression among 18 to 59 years of age (OR=0.12, 95% CI: 0.02-0.55), non-Hispanic blacks (OR=0, 95% CI: 0.00-0.00), other races (OR=0.14, 95% CI: 0.04-0.55), below high school (OR=0.06, 95% CI: 0.01-0.33), above high school (OR=0.12, 95% CI: 0.02-0.89), married/cohabiting (OR=0.06, 95% CI: 0.01-0.25), overweight/obese (OR=0.06, 95% CI: 0.02-0.21), and non-users of hormone replacement therapy (OR=0.12, 95% CI: 0.04-0.42).

A significant negative correlation exists between CVH levels and the risk of depression in postmenopausal women. This underscores the importance of CVH in the mental health of postmenopausal women. Healthcare providers should prioritize the potential psychological impact of CVH on postmenopausal women and incorporate it into comprehensive strategies for depression prevention and intervention.

To evaluate the current status of health-related quality of life (HRQoL) and its influencing factors in patients with Wilson’s disease (WD), and to compare them with the standards of the general population in China.

A cross-sectional study of 123 patients with WD from July 14, 2023, to March 14, 2024, was conducted to assess the HRQoL using the EuroQol five-dimensional three-level questionnaire (EQ-5D-3L) and converted using the Chinese value set. The Tobit regression model was used to identify potential factors associated with HRQoL.

The health utility value of WD patients grouped by age was significantly lower than that of the general population (P<0.001). Patients also reported more health problems in all dimensions of EQ-5D-3L than in the general population (P<0.001). The Tobit regression analysis shows that per capita monthly income, low-copper diet, phenotypes, and mental health status are significantly correlated with health utility values.

Patients with WD have a worse HRQoL than the general population in China. The HRQoL of patients can be improved by advocating a scientific low-copper diet, raising health awareness, and paying more attention to the psychological conditions of patients with WD, especially neuropsychiatric patients.

To assess the impact of the utilization of basic public health services on residents’ willingness to the first choice of medical institutions for treatment.

This study utilized information from a resident survey conducted by the Provincial Natural Science Foundation Project. The project adopted a multi-stage sampling method and utilized the resident household survey questionnaire, which was conducted from January 2020 to October 2021 in Shandong Province. A total of 2 917 valid questionnaires were obtained, and the survey respondents were residents aged 15 and above. Binary logistic regression model and propensity score matching (PSM) method were used for analysis.

The proportion of residents who have established health records was 63.9%, and the utilization rate of health education was 49.6%.83.8% respondents preferred to choose primary healthinstitutions for treatment. The results of propensity score matching showed that under the three methods of kernel matching, radius matching, and nearest neighbor matching, the average treatment effect on the treated (ATT) for the utilization of health education in residents’ willingness to the first choice of healthcare institutions were 0.084 3, 0.088 9, and 0.090 3, respectively.

The consultation rate of primary health institutions is performing well. Essential public Health services usage had a positive effect on residents’ willingness to choose primary health institutions for medical treatment. It is recommended to increase constructive investment in primary health institutions, enhance the service supply capacity of providers and strengthen the relevanceof basic public health services for demanders.

To explore the short-term effects of personalized nutritional support on serum albumin (ALB) levels in middle-aged and elderly patients using real-world data and multiple factors.

A retrospective study was conducted on patients aged 50 and above who were at nutritional risk in the nutrition consultation cases at the Second People’s Hospital of Chengdu from August 2020 to June 2024. Clinical data and laboratory test results were collected, and patients were grouped according to different nutritional intervention methods. The ALB decline of patients after 1week of nutritional intervention was analyzed, and the impact of different nutritional intervention methods on ALB decline was evaluated using a logistics regression model.

A total of 1 136 patients were included in the study, with 627 patients showing a decrease in ALB and 509 patients showing no decrease in ALB. Univariate analysis revealed statistically significant differences in age, tube feeding, nutritional intervention methods, chronic kidney disease, cerebral infarction, other site infections, and tumor morbidity. Multivariate analysis was conducted with the dietary guidance group as the control group. Oral nutritional supplementation (OR=0.683, 95%CI: 0.500-0.933), personalized nutritional support intervention (OR=0.409, 95% CI: 0.279-0.601), and other site infections (OR=0.776, 95% CI: 0.607-0.994) were protective factors for ALB decline; Tube feeding (OR=1.766, 95% CI: 1.317-2.369) and cerebral infarction (OR=1.866,95% CI: 1.424-2.444) are risk factors for the decline of ALB.

Personalized nutritional support can effectively prevent the decline of serum albumin in middle-aged and elderly hospitalized patients, and has potential clinical value.

To analyze the survival time of HIV/AIDS patients in Hebei province, and to explore the influencing factors, so as to provide basis for improving the quality of life of patients.

Retrospective cohort study was used to collect information of HIV/AIDS in Hebei province from 1989 to 2022. Life table was used to describe the survival status. Log-rank test and Cox regression were used to analysis the influencing factors of survival time.

There were 22 563 cases of HIV/AIDS, with males accounting for 88.7% and homosexual transmission accounting for 62.1%. The average age at the time of discovery was 38.1±13.9. The 1-year,3-year,5-year and 10-year cumulative survival rates of HIV/AIDS patients were 91.46%,88.03%, 85.56% and 79.34%. The risk of death in female was lower than that in male (HR=0.824, 95% CI: 0.713-0.953). The risk of death in patients receiving antiviral treatment was lower than in those who have not received treatment (HR=0.079, 95% CI:0.069-0.091). Baseline CD4 cell counts ranging from 200 to 349 cells/μl (HR=0.451, 95% CI: 0.222-0.914), 350 to 499 cells/μl (HR=0.354, 95% CI: 0.175-0.719), and above 500 cells/μl (HR=0.342, 95% CI: 0.168-0.693) have a lower risk of death. People over 50 years old have a higher risk of death (HR=2.585, 95% CI: 2.143-3.117). Among the sources of case samples, the case death risk of those from HIV testing and counseling was lower than the cases from medical institutions(HR=0.444,95% CI: 0.387-0.510). And the case death risk of those from detainees was lower than the cases from medical institutions(HR=0.417,95% CI: 0.297-0.584).

Gender, educational level, baseline CD4 cell count, sample source, age at discovery, and antiviral treatment were influencing factors on survival time. Early detection, early treatment, strengthening the publicity and education of key groups, paying attention to the elderly cases over 50 years old, and strengthening medical personnel to actively carry out AIDS testing and consulting services have a positive effect on prolonging the survival time of HIV/AIDS cases.

To investigate the prevalence and influencing factors of insufficient sleep and excessive sleep among Chinese adults from 2010 to 2020, thereby providing a basis for policies aimed atimproving sleep conditions for adults.

Data from the China Family Panel Studies (CFPS) between 2010 and 2020 were utilized. Self-reported nighttime sleep duration was measured, with less than 7 hours classified as insufficient sleep and 9 hours or more classified as excessive sleep. Chi-square tests and Poisson regression models were employed to analyze the frequency and influencing factors.

A total of 9,505 individuals were included in the study. The results indicated that 45.84% of adults reported never experiencing insufficient sleep, while 48.27% of adults reported never experiencing excessive sleep. Poisson regression analysis indicated that females (RR=1.073, 95% CI: 1.028-1.119), increasing age (RR=1.404, 95% CI: 1.305-1.511; RR=1.887, 95% CI: 1.755-2.030; RR=2.092, 95% CI: 1.934-2.263), urban areas (RR=1.219, 95% CI: 1.178-1.260), eastern region (RR=1.346, 95% CI: 1.287-1.409) and central region (RR=1.430, 95% CI: 1.370-1.492), general health (RR=1.114, 95% CI: 1.075-1.154) and unhealthy status (RR=1.164, 95% CI: 1.109-1.221), and higher depression symptom scores (RR=1.018, 95% CI: 1.014-1.022) are risk factors for increased frequency of insufficient sleep. Married/cohabiting (RR=0.894, 95% CI: 0.816-0.980), high school (RR=0.951, 95% CI: 0.904-1.000) and college or above (RR=0.894, 95% CI: 0.828-0.965), BMI<18.5 kg/m² (RR=0.932, 95% CI: 0.871-0.996) are protective factors against increased frequency of insufficient sleep. Aged 30-44 years (RR=0.757, 95% CI: 0.712-0.806) and aged 45-59 years (RR=0.834, 95% CI: 0.783-0.888), married/cohabiting (RR=0.920, 95% CI: 0.847-0.999), junior high school (RR=0.822, 95% CI: 0.789-0.856), high school (RR=0.667, 95% CI: 0.627-0.709) and college or above (RR=0.416, 95% CI: 0.371-0.467), urban (RR=0.737, 95% CI: 0.709-0.766), eastern region (RR=0.698, 95% CI: 0.667-0.730) and central region (RR=0.768, 95% CI: 0.737-0.799) are protective factors against increased frequency of excessive sleep, while unhealthy (RR=1.100, 95% CI: 1.046-1.158) is a risk factor for increased frequency of excessive sleep.

The frequency of insufficient sleep and excessive sleep among Chinese adults is closely related to various sociodemographic factors, physical and mental health conditions, and smoking habits. The government and all sectors of society should prioritize high importance on the sleep conditions of adults and take effective measures to improve sleep health literacy among adult population, ultimately promoting overall health and well-being.