To analyze the prevalence of three cardiovascular diseases categories (hypertension, coronary heart disease and stroke), and their impact on activity of daily living (ADL) among the elderly in rural Dayao County of Yunnan Province.

A multi-stage stratified random sampling method was employed in selecting 1 382 rural residents≥60 years from Dayao County for questionnaire survey and physical examination.Multivariate logistic regression models were applied to analyze the association between the prevalence of hypertension, coronary heart disease (CHD), stroke and ADL.

Among the interviewed respondents, the prevalence of hypertension, CHD, stroke, and the impaired rate of physical activity of daily life (PADL), instrumental activity of daily life (IADL) and ADL was 66.2%, 14.6%, 5.9%, 6.6%, 36.5%, and 37.2%, respectively. The prevalence of hypertension, CHD, and stroke and impaired rate of PADL, IADL, and ADL increased with age (, P<0.05). Females had higher prevalence of hypertension, impaired rate of IADL and ADL than males (χ²=7.319, χ²=56.112, χ²=52.510, P<0.05). Older adults with lower level of education had lower prevalence of CHD (χ²=3.930, P<0.05) while they had higher impaired rate of PADL, IADL, and ADL than their counterparts (χ²=7.438, χ²=99.487, χ²=101.057, P<0.001). Similarly, older adults with lower household incomes had lower prevalence of CHD and stroke (χ²=6.442,χ²=4.250, P<0.05) while they had higher impaired rate of IADL and ADL (χ²=6.517, χ²=4.934, P<0.05) than their counterparts. The outcomes of the analysis utilizing multivariate logistic regression suggested that hypertensive older adults (OR=1.760, 95% CI: 1.037-2.985) and older adults who suffered from stroke (OR=3.692, 95% CI:1.989-6.856) were more likely to have higher impaired rate of PADL than their counterparts.

There is a relatively high prevalence of three types of cardiovascular diseases while low level of daily living activity among older adults in Dayao County. Reducing the prevalence of hypertension and stroke would be helpful to alleviate the impaired rate of activity of daily living.

To explore the mediating effect of depressive symptoms on the relationship between handgrip strength and activities of daily living (ADL) in older adults, so as to provide a reference for the prevention and intervention of ADL impairment in this population.

Based on the 2015 survey data from the China Health and Retirement Longitudinal Study (CHARLS), a study was conducted involving 2 344 seniors aged 60 and above. Descriptive analysis and partial correlation analysis were conducted using SPSS 25.0, and the PROCESS macro program was employed to test for mediation effects.

The detection rate of low handgrip strength among elderly individuals in our country is 20.09%, the detection rate of depressive symptoms is 34.94%, and the rate of Activities of Daily Living (ADL) impairment is 20.95%. Handgrip strength is negatively correlated with depressive symptoms (r=-0.055, P<0.01); handgrip strength is also negatively correlated with ADL impairment (r=-0.143, P<0.001), while depressive symptoms are positively correlated with ADL impairment (r=0.259, P<0.001). Depressive symptoms have a partial mediating effect between handgrip strength and ADL in the elderly, with the mediation effect accounting for 12.68%.

Handgrip strength can have a significant impact on the activities of daily living (ADL) of older adults due to symptoms of depression, highlighting the importance of self-exercise for this demographic. Interventions that combine improvements in handgrip strength with a reduction in the risk of depressive symptoms may be effective in maintaining the daily living capabilities of older individuals.

Toanalyze epidemiological characteristics and influencing factors of mumps in Qinghai Province from 2014 to 2023 and provide reference for the prevention and control of mumps.

The incidence data of Mumps in Qinghai Province from 2014 to 2023 were collected, and the descriptive method was used to analyze the change changing pattern of Mumps incidence. Geographically and temporally weighted regression (GTWR) was established, the mean regression coefficients were calculated, and different factors (Social factors: GDP per capita, number of students in schools; Natural factors: annual average temperature, annual average wind speed, annual total precipitation, annual total sunshine hours) on the incidence of Mumps.

From 2014 to 2023, a total of 14 278 cases of Mumps were reported in Qinghai Province, with an average annual incidence rate of 24.06/100 000, of which the highest in 2019 (65.62/100 000) and the lowest in 2016 (8.28/100 000). The seasonal index showed that Mumps showed a bimodal epidemic trend in winter and summer. The male-to-female sex ratio was 1.2:1, the highest number of cases was found in 5-<15 years old (40.66%) and 15-<25 years old (35.94%); and the occupation was dominated by students (69.15%). The incidence rate was the highest in Xining City (29.29/100 000 people) and the lowest in Yushu Prefecture (8.49/100 000 people). The GTWR model results showed that there were positive associations between annual average temperature, per capita GDP, annual total precipitation and the incidence of Mumps; and negative associations between the number of students in schools, annual average wind speed, and annual total sunshine hours with the incidence rate of Mumps.

The reported incidence of Mumps in Qinghai showed an overall downward trend. Focus on children and students aged 5 to 25 in Xining; social and natural factors have spatial heterogeneity on the incidence of Mumps, and regional prevention and control measures can be formulated in each region according to the actual situation.

To explore the relationship between screen time and mental health problems of adolescents using restricted cubic spline model.

A questionnaire survey was conducted among 3 960 junior and senior high school students in Jinan, Weifang and Qingdao cities of Shandong Province from February to March 2023. Logistic regression model and restricted cubic spline model were used to analyze the correlation strength and dose-response relationship between screen time and psychological problems. Result 46.41% of adolescents in middle and high school had mental problems, and 29.70% reported that screen time(ST)>2 h/d. There was a nonlinear dose-response relationship between mild psychological problems and ST on rest day (P_nonlinear＝0.003, P_overall＝0.003), and the curve was approximately "J" shaped, and the risk increased beyond 1.5 h/d. ST>2 h/d on rest days was associated with mild psychological problems (OR=1.300, 95% CI;1.085-1.558). Stratified analysis showed that there was a nonlinear correlation between ST on rest day and mild mental problems (P_nonlinear<0.001), and a linear correlation between ST and moderate mental problems (P_nonlinear>0.05)(P_overall<0.001). Only smartphones and tablets were linearly associated with mild mental health problems (P_overall＝0.004), with increased risk beyond 2.0 h/d.

The average screen time over 1.5 h/d increases the risk of psychological problems. It is suggested to lighten students'study burden after class and reduce the use of electronic devices on rest days.

To comprehensively evaluate the medical quality level of tertiary general hospitals in Guangxi and propose targeted quality improvement strategies.

Through the fuzzy union of entropy-weighted TOPSIS method and RSR method, we evaluated the medical quality of general hospitals in Guangxi cities and towns from 2019 to 2022, and utilized the obstacle degree model for the diagnosis of obstacle factors of medical quality development.

The top three weights of medical quality evaluation indexes were the percentage of special medical service volume (0.334), the number of patients referred downstream (0.216), and the percentage of commented prescriptions (0.107); the medical quality levels of Nanning City, Liuzhou City, and Guilin City were in the forefront, and that of Fangchenggang City, Laibin City, and Hechi City were in the back; the barrier factor diagnosis showed that the medical quality was greatly affected by functional positioning and rational drug use, with the barrier degree of 73.77% and 17.70% respectively, but the barrier degree of functional positioning showed a decreasing trend year by year, and the barrier degree of rational drug use showed a rising trend year by year, in which the barrier degree of rational drug use in Nanning City and Guilin City in 2022 had exceeded that of functional positioning.

The development of healthcare quality is not balanced between cities in Guangxi and the focus of development is different, tertiary general hospitals should clarify their own functional positioning and strengthen the guarantee of rational medication use.

To analyze the disease burden trends of stroke and its subtypes in China.

Using data from the Global Burden of Disease Study, descriptive statistical analysis and Joinpoint regression models were employed to examine trends from 1990 to 2021, while the Bayesian age-period-cohort (BAPC) model was applied to predict disease burden up to 2036.

From 1990 to 2021, the number of stroke cases in China increased by 142.65%, yet the standardized incidence rate decreased by 9.78%, and the mortality rate dropped by 43.01%. Subtype analysis revealed a significant increase of 35.72% in the incidence of ischemic stroke, while the mortality rate from subarachnoid hemorrhage declined by 82.70%. In 2021, the male-to-female ratio of incidence rose to 1.73, and the decrease in the Disability-Adjusted Life Years (DALYs) rate was 16 percentage points higher for women than for men, indicating a widening gender disparity compared to 1990. The age distribution exhibited a bimodal pattern, with the highest incidence rate observed in the 75-79 age group (2 005.45 per 100 000), and the largest decrease in standardized DALYs occurred in the 55-59 age group, increasing by 57.61% compared to 1990. Attributable risk analysis showed that high systolic blood pressure remains the primary risk factor, with a standardized mortality rate of 77.73 per 100 000. However, deaths associated with low physical activity have surged by 222.54% in the past two decades. By 2036, it is predicted that the standardized incidence of stroke among women will increase by 5.26% compared to 2021, while the mortality rate among men will decrease by 16.69%, further exacerbating gender disparities.

While China has achieved progress in stroke prevention, challenges persist due to population aging and evolving risk factors. Targeted interventions addressing the rise of ischemic stroke, younger-onset cases, and gender disparities are urgently needed, alongside enhanced air pollution control, metabolic syndrome management, and regionalized tertiary prevention networks.

To investigate the overall association between co-exposure to metals and phthalates (PAEs) and blood lipid indicators, as well as the role of metabolic disturbances and endogenous metabolites as mediators in this association.

A total of 74 residents from Guangzhou (n=35) and Qingyuan (n=39) were randomly selected, and their urine samples were analyzed for 15 metal elements and 9 PAE metabolites. Generalized linear models and generalized weighted quantile sum (gWQS) regression models were used to assess the association between individual pollutants, combined exposure, and blood lipid levels. Non-targeted metabolomics, meet-in-the-Middle (MITM) approach, and mediation analysis were performed to identify endogenous metabolites and metabolic pathways linking combined exposure with blood lipid changes, and to explore the mediating effects of metabolites.

The concentrations of seven metals, including arsenic and cadmium, and four PAE metabolites, including mono-isobutyl phthalate (MiBP), were significantly positively correlated with increased total cholesterol (TC). The weighted quantile sum (WQS) index, which represented the overall load of metal and PAE combined exposure, showed a dose-dependent relationship with TC increase. For each one-unit increase in the WQS index, TC increased by 0.43 (95% CI: 0.05-0.82) mmol/L. Eight metabolites, including perilla acid, dehydroepiandrosterone, octanoylcarnitine, arachidonic acid, estrone, kynurenine, glucose-6-phosphate, and ferulic acid, were significantly associated with the WQS index and TC levels, and exhibited significant mediating effects, and the corresponding mediation effects were 0.09 (95% CI: 0.02-0.27)，0.18 (95% CI: 0.04-0.35)、0.21 (95% CI: 0.02-0.44)、0.12 (95% CI: 0.02-0.24)、0.08 (95% CI: 0.02-0.21)、0.08 (95% CI: 0.01-0.20) and 0.09 (95% CI: 0.01-0.19), respectively. The biosynthesis pathway of steroid hormones was significantly enriched.

The biosynthesis pathway of steroid hormones and metabolites such as dehydroepiandrosterone and androstenone may mediate the overall association between combined exposure to metals and PAEs and the increase in TC levels, providing the metabolic perspective for the overall effect on blood lipids of co-exposure to metals and PAEs.

To construct and validate a prediction model for high-risk sexual behaviors among rural residents aged 50 and above, in order to achieve early identification of high-risk groups and provide a scientific basis for the formulation of precise intervention measures.

From February to April 2024, 50-year-old and above permanent residents were conveniently sampled in rural areas of Luzhou City, Sichuan Province as the modeling group. From May to June, residents of the same age group were selected in rural areas of Liangshan Yi Autonomous Prefecture using the same method as the validation group. LASSO regression was used to screen variables, and then Logistic regression analysis was conducted on the screened variables. Variables with a P value less than 0.05 were used to construct a prediction model, and its predictive performance was evaluated.

The incidence rate of high-risk sexual behavior in this study was 28.52% (154/540).The predictive model included five predictive factors: gender, sexual behavior under the influence of alcohol, history of sexually transmitted disease infection, having a regular sexual partner, and social support, providing a scientific basis for the prediction of high-risk sexual behavior. The area under the ROC curve of the predictive model in the modeling group and the validation group was 0.940(95% CI:0.914-0.965) and 0.971(95% CI:0.951-0.992), respectively. The calibration curves showed good consistency, and the P values of the Hosmer-Lemeshow test were all greater than 0.05.The DCA had high positive yield between 1%-93% and 2%-98%, respectively.

The prediction model based on LASSO-Logistic regression analysis demonstrated good predictive performance and potential for practical application.

To analyze the trend of Colon and rectum cancer (CRC) burden attributable to low physical activity in China from 1990 to 2021, and to provide a reference for the development of effective public health strategies and healthcare resource allocation.

Relying on the Global Burden of Disease Study 2021 database, this study focused on the data of CRC burden attributable to low physical activity, including death and disability-adjusted life years (DALYs), among people ≥25 years old in China. Joinpoint regression was used to analyze the trends and turning points of disease burden changes, age, period and cohort effects of mortality were estimated with the age-period-cohort model, and autoregressive integral moving average (ARIMA) model was used to predict the disease burden dynamics in 2022-2030.

Between 1990 and 2021, the number of deaths, crude death rate, number of DALYs, and crude DALY rate attributable to low physical activity for CRC in China increased, with the number of deaths rising from 5 735 to 16 698, and the crude death rate from 0.78/100 000 to 1.53/100 000; the number of DALYs increased from 128 353 to 320 464 years. Crude DALY rate increased from 17.55/100 000 to 29.44/100 000.Joinpoint analysis showed that the mortality and DALY rates were increasing; the total population had a fluctuating downward trend in the standardized mortality rate and the standardized DALY rate, with an average annual percentage change of -0.21%(P>0.05) and -0.29(P<0.05) for males and females, respectively. Gender differences were observed in age-standardized mortality and DALY rate trends. The age effect showed that the CRC mortality rate attributable to low physical activity basically increased with age in China, and the relative risk (RR) ranged from 0.04 to 10.75 in each age group; the period effect showed that the mortality rate monotonically increased with the period, and the RR ranged from 0.69 to 1.59 in each period; and the cohort effect showed that the mortality rate progressively decreased with the development of birth cohorts, and the RR of each birth cohort ranged from 0.25 to 5.23. The differences in the effects between genders were not significant.The ARIMA model showed that the burden will continue to increase in China from 2022 to 2030.

The burden of CRC attributable to low physical activity in China showed a significant upward trend from 1990 to 2021, with gender differences. The age, period, and cohort effects of its mortality risk are evident. Targeted measures are urgently needed to effectively curb the rising disease burden.